Continuous near infrared glucose sensor

连续近红外葡萄糖传感器

• 批准号: 8100188
• 负责人: MARK A. ARNOLD
• 金额: $ 57.7万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8100188
• 关键词: Animal Model; Biological; Calibration; Companions; Complex; Custom; Data Analyses; Detection; Development; Devices; Electronics; Elements; Engineering; Evaluation; Glucose; Goals; Grant; Health; Human; Implant; In Vitro; Intercellular Fluid; Laboratories; Laboratory Animals; Laboratory Rat; Light; Measurement; Measures; Methods; Modeling; Noise; Output; Performance; Process; Property; Reading; Research; Sampling; Semiconductors; Series; Source; System; Time; Ultrafiltration; awake; base; clinically relevant; data acquisition; design; detector; glucose sensor; improved; in vivo; innovation; miniaturize; novel; programs; prototype; research study; solid state

DESCRIPTION (provided by applicant): A research program is described to develop a novel miniaturized solid-state spectrometer designed for analytical measurements over the combination region of the near infrared spectrum (2.0-2.5 ?m or 4000-5000 cm-1). The objective is to develop a robust spectrometer microsensor that is capable of accurate analytical measurements under non-ideal and uncontrolled ambient conditions outside the laboratory. Progress to date demonstrates the feasibility and utility of this approach for the continuous measurement of glucose in interstitial fluid collected by an ultrafiltration probe implanted subcutaneously in laboratory rats. Improvements in the current spectrometer are identified to achieve a limit of detection of 1 mM for glucose from spectra collected over a one-minute period. The research plan is designed to realize these improvements by enhancing the output of custom-made semiconductor light emitting diodes (LEDs), improving the detectivity of an innovative focal plan array detector system, implementing a companion reference channel, and developing data analysis methods to improve the long-term stability of the calibration model. A new electronic interface is proposed to customize and miniaturize data acquisition. Spectrometer prototypes will be characterized and validated in a series of in vitro and in vivo experiments that include continuous and selective glucose measurements in non-anesthetized, freely moving laboratory rats. At the end of the requested four-year grant period, our objective is to have an optimized near infrared microsensor spectrometer that is ready for evaluation in human trials for the continuous measurement of glucose. PUBLIC HEALTH RELEVANCE A novel glucose sensor is proposed based on an innovative miniaturized, all solid-state near infrared spectrometer that is constructed from a set of customized optoelectronic devices. The overall objective is to measure clinically relevant levels of glucose in one minute under non- laboratory conditions. Analytical properties will be validated in laboratory animals.

描述（由申请人提供）：描述了一项研究计划，以开发一种新型的微型固态光谱仪，旨在在近红外光谱（2.0-2.5？m或4000-5000 cm-1）的组合区域上进行分析测量。目的是开发一个可靠的光谱仪微型传感器，该微型传感器能够在实验室以外的非理想和不受控制的环境条件下进行准确的分析测量。迄今为止的进展证明了这种方法的可行性和实用性，可通过在实验室大鼠中皮下植入的超滤探针收集的间隙液中连续测量葡萄糖。确定了当前光谱仪的改进，以达到一分钟内收集的光谱的1 mm检测限。该研究计划旨在通过增强定制半导体光发射二极管（LED）的输出来实现这些改进，从而提高了创新的焦点计划阵列阵列阵列阵列系统的检测，实施伴随参考渠道以及开发数据分析方法以提高校准模型的长期稳定性。提出了一种新的电子界面来自定义和小型数据获取。光谱仪的原型将在一系列体外和体内实验中进行表征和验证，其中包括在非麻醉，自由移动的实验室大鼠中连续和选择性葡萄糖测量。在请求的四年赠款期结束时，我们的目标是具有优化的近红外微传感器光谱仪，该光谱仪准备在人体试验中进行评估，以连续测量葡萄糖。公共卫生相关性是一种新型的葡萄糖传感器，该传感器是基于创新的小型，所有固态的近红外光谱仪，该固体近红外光谱仪是由一组定制的光电设备构建的。总体目标是在非实验室条件下一分钟内测量临床相关的葡萄糖水平。分析性能将在实验动物中得到验证。