Instrumental Designs for Near Infrared Glucose Monitors

近红外血糖监测仪的仪器设计

• 批准号: 6767316
• 负责人: MARK A. ARNOLD
• 金额: $ 19.86万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6767316
• 关键词: biomedical equipment development; blood filtration; blood glucose; blood tests; computer system hardware; glucose clamp technique; hypoglycemia; infrared spectrometry; laboratory rat; monitoring device; noninvasive diagnosis

DESCRIPTION (provided by applicant): Two novel solid-state instrumental designs are described for use in the noninvasive measurement of blood glucose. Both instruments implement transmission measurements of near-infrared light through a tissue sample and allow the encoding of multivariate calibration models in hardware. Each instrument is based on the sequential measurement of pre-defined combinations of near- infrared wavelengths that are specified in the form of filter bandpass functions. In the two designs, these filter profiles are generated with either a digital micromirror array (MMA) or an acousto-optic tunable filter (AOT F). The MMA allows the specification of filter profiles of arbitrary complexity, while the AOTF allows the generation of filters with simpler square-wave shapes. A computational model and numerical optimization procedures are described for use in defining optimal filter profiles that result in the measurement of unique spectral patterns that are selective for blood glucose. These filter profiles are analogous to the components extracted by multivariate calibration models from contiguous spectral data acquired by a conventional spectrometer. Performing these discrete filter-based measurements gains both throughput and multiplex advantages, and allows the creation of rugged instrumental designs that are compatible with noninvasive blood glucose measurements made by diabetic patients outside the controlled environment of the laboratory. Both in vitro experiments and in vivo studies with a rat model are proposed for use in characterizing the performance and analytical utility of these instrumental designs. The experimental and computational work will be directed to the overall goal of developing a noninvasive nocturnal hypoglycemic alarm.

描述（由申请人提供）：描述了两种新型的固态仪器设计，用于用于血糖的无创测量。两种仪器通过组织样品实施了近红外光的传输测量，并允许在硬件中编码多元校准模型。每种仪器均基于以滤波器带通函数的形式指定的近红外波长的预定义组合的顺序测量。在这两种设计中，这些滤波器轮廓是用数字微ror阵列（MMA）或声学可调滤波器（AOT F）生成的。 MMA允许指定任意复杂性的滤波器轮廓，而AOTF允许使用更简单的方波形状产生过滤器。描述了一种计算模型和数值优化程序，用于定义最佳滤波器轮廓，从而测量了对血糖有选择性的独特光谱模式。这些滤镜轮廓类似于从传统光谱仪中获取的连续光谱数据中提取的组件。进行这些离散滤波器的测量值既可以获得吞吐量和多重优势，又可以创建与糖尿病患者在实验室受控环境之外进行的与非侵入性血糖测量兼容的坚固仪器设计。在体外实验和使用大鼠模型的体内研究都均已用于表征这些工具设计的性能和分析效用。实验和计算工作将针对开发非侵入性夜间降血糖警报的总体目标。