Myostatin and glucose metabolism

肌肉生长抑制素和葡萄糖代谢

• 批准号: 8148964
• 负责人: Alexandra Christine McPherron
• 金额: $ 42.27万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8148964
• 关键词: glucose metabolism; myostatin

We have generated and analyzed the effects of muscle-specific inhibition of myostatin signaling in an obese hyperglycemic mouse model. We have measured energy intake and energy expenditure, muscle and fat weights and histology, and performed analysis of glucose metabolism in these mice. We have also analyzed blood glucose and glucose and insulin tolerance after myostatin inhibition in other mouse models of diabetes to determine which types of diabetes might be ameliorated by myostatin inhibition.

我们在肥胖高血糖小鼠模型中生成并分析了肌肉特异性抑制肌生长抑制素信号传导的效果。我们测量了这些小鼠的能量摄入和能量消耗、肌肉和脂肪重量以及组织学，并对葡萄糖代谢进行了分析。我们还分析了其他糖尿病小鼠模型中肌生长抑制素抑制后的血糖以及葡萄糖和胰岛素耐量，以确定肌生长抑制素抑制可以改善哪些类型的糖尿病。