Continuous wearable monitor for the detection and release of Freezing of Gait

用于检测和解除冻结步态的连续可穿戴监视器

• 批准号: 10081773
• 负责人: John Paul Condon
• 金额: $ 69.92万
• 依托单位: INNOVATIVE DESIGN LABS, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10081773
• 关键词: Acoustics; Affect; Algorithms; American; Area; Bluetooth; Cellular Phone; Charge; Clinical; Clinical Trials; Collaborations; Communities; Companions; Computer software; Consult; Cues; Deep Brain Stimulation; Detection; Devices; Engineering; Event; Floor; Freezing; Gait; Generations; Home environment; Human; Impairment; Incidence; Individual; Intervention; Laboratories; Lasers; Lead; Levodopa; Medical Device; Minnesota; Monitor; Movement; Movement Disorders; National Institute of Neurological Disorders and Stroke; Neurodegenerative Disorders; Parkinson Disease; Patients; Periodicity; Pharmacological Treatment; Phase; Physician Executives; Population; Prevalence; Production; Quality of life; Research; Resistance; Shoes; Specificity; Stimulus; Symptoms; System; Testing; Therapeutic; Time; United States National Institutes of Health; Universities; Walkers; Walking; Wireless Technology; Work; algorithm development; design; falls; habituation; improved; innovation; instrument; mobile application; operation; patient mobility; prototype; recruit; response; sensor; sensory stimulus

Project Summary/Abstract Proposed is a system for daily in-community use that detects the occurrence of FOG and triggers external cueing stimuli to unfreeze the individual. Significance: Parkinson's disease (PD) affects more than one million Americans making it the second-most common neurodegenerative disorder in the US. Its prevalence is expected to double by 2040. More than 30% of all people with PD will develop Freezing of Gait (FOG), a symptom characterized by episodic impairments in the ability to initiate gait and the spontaneous arrest of movement during walking. A curious feature of FOG is that it can be overcome when an external sensory stimulus (cue) is presented. Research has shown that if the cue is exogenously presented, the incidence of FOG events is greatly reduced. Hypothesis: We hypothesize that easy to use, accurate, exogenous queuing in response to FOG events will decrease duration of these events and ultimately lead to improved quality of life. Specific Aims: In Phase II IDL and its collaborators will: (1) Develop a production ready system, (2) Develop a companion mobile app for the proposed system and refine previously developed FOG detection algorithms, and (3) Validate the proper operation of the system and demonstrate its efficacy through lab and in- community testing.

项目概要/摘要 提出的是一种供社区日常使用的系统，可检测 FOG 的发生并触发外部 提示刺激以解冻个体。意义：帕金森病 (PD) 影响超过一百万人 美国人使其成为美国第二常见的神经退行性疾病。其患病率是 预计到 2040 年将翻一番。超过 30% 的帕金森病患者会出现冻结步态 (FOG)，这是一种 以启动步态和自发停止能力的间歇性障碍为特征的症状 行走时的运动。 FOG 的一个奇怪的特征是，当外部感官受到影响时，它可以被克服。 呈现刺激（提示）。研究表明，如果提示是外源性的，则发生 FOG事件大大减少。假设：我们假设易于使用、准确、外源排队 对 FOG 事件的响应将减少这些事件的持续时间，并最终提高 生活。具体目标：在第二阶段，IDL 及其合作者将：(1) 开发一个生产就绪系统，(2) 为提议的系统开发配套移动应用程序并完善之前开发的 FOG 检测 (3) 验证系统的正确运行并通过实验室和内部展示其功效 社区测试。