Domestic Indoor PM & Childhood Asthma Morbidity

国内室内PM

基本信息

批准号：
8294885
负责人：
GREGORY B DIETTE
金额：
$ 38.47万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8294885
关键词：
Address Adverse effects Affect African American Air Air Pollution Allergens Allergic Animal Model Asthma Biological Markers Blood Breathing Cells Child Childhood Asthma Complement Complex Data Disease Dust Environment Environmental Exposure Exhalation Exposure to Extrinsic asthma Health Health Policy Home environment Human IgE Indoor Air Quality Inflammation Inflammatory Irrigation Lead Leukotriene E4 Life Link Low income Measures Minority Morbidity - disease rate Mus Nasal Lavage Fluid Neighborhoods Nitric Oxide Nose Oxidative Stress Oxidative Stress Pathway Participant Pathway interactions Play Pollution Predisposition Recruitment Activity Research Research Personnel Respiratory physiology Role Serum Symptoms System Time Urine Variant Vulnerable Populations airway inflammation base boys clinical effect human subject improved inner city member pollutant programs research study response suburb urinary

项目摘要

Asthma is a common disorder among children. Children with asthma have multiple and complex environmental exposures, including inhalable pollutants and allergens. The response to inhaled exposures is characterized by airway inflammation, and possibly by activation of oxidative stress pathways. In theU.S., the burden of asthma is enormous, with a disproportionate impact on vulnerable groups including young children, African-Americans and those living in the inner city. These most vulnerable people often inhabit an environment that has excessive outdoor pollution levels, as well as high levels of indoor allergens and pollutants. We plan to address the critical questions of the role of the indoor environment on childhood asthma, we propose a panel study of children living in urban neighborhoods enriched with African-American and lower income participants. This real world field-based study will complement the findings from Projects 2, 3 and 4, which will similarly examine the effects of PM and allergen, but in controlled settings using human subjects, animal models and cell systems. We will recruit atopic asthmatics, including those with and without sensitization to mouse allergen, as well as normal controls, to address the following Specific Aims: Aim 1 .A: To determine the contribution of indoor PM to day-to-day variation in lung function and asthma control, among inner city children with atopic asthma. Aim IB: To determine if higher indoor PM exposure is associatedwith biomarkers of inflammation and oxidative stress. Aim 2A: To determine if mouse IgE-positive asthmatics with high mouse allergen exposure have greater susceptibility to PMthan other atopic asthmatics (mouse IgE-negative and/or with low mouse allergen exposure). Aim 2.B: To determine if mouse IgE-positive asthmaticswith high mouse allergen exposure (> 0.5 ug/g of Mus m 1) have elevated biomarkers of inflammation and oxidative stress in response to PM compared to those who are mouse IgE-E negative or who have low mouse allergen exposure..

哮喘是儿童中的常见疾病。儿童哮喘有多种且复杂的症状环境暴露，包括可吸入污染物和过敏原。对吸入暴露的反应是其特征是气道炎症，并且可能是氧化应激途径的激活。在美国，哮喘的负担是巨大的，对包括年轻人在内的弱势群体造成不成比例的影响儿童、非裔美国人和居住在市中心的人们。这些最脆弱的人通常居住在室外污染严重、室内过敏原含量高的环境污染物。我们计划解决室内环境对儿童哮喘的作用的关键问题，我们提出一项针对居住在非洲裔美国人和低收入城市社区的儿童的小组研究收入参与者。这项基于现实世界的实地研究将补充项目 2、3 和 4 的研究结果，它将类似地检查 PM 和过敏原的影响，但在受控环境中使用人类受试者，动物模型和细胞系统。我们将招募特应性哮喘患者，包括患有或不患有过敏性哮喘的患者对小鼠过敏原以及正常对照的敏感性，以实现以下具体目标：目标 1.A：确定室内 PM 对肺功能和哮喘日常变化的影响控制内城区患有特应性哮喘的儿童。目标 IB：确定较高的室内 PM 暴露是否与炎症和炎症的生物标志物相关氧化应激。目标 2A：确定小鼠 IgE 阳性哮喘患者与高小鼠过敏原暴露是否有更大的差异比其他特应性哮喘患者（小鼠 IgE 阴性和/或小鼠过敏原低）对 PM 的易感性接触）。目标 2.B：确定小鼠 IgE 阳性哮喘患者是否具有高小鼠过敏原暴露（> 0.5 ug/g 与小鼠相比，小鼠 m 1) 对 PM 的反应具有升高的炎症和氧化应激生物标志物小鼠 IgE-E 阴性或小鼠过敏原暴露量较低的人。