Mentoring and Patient Oriented Research in Asthma

哮喘的指导和以患者为导向的研究

• 批准号: 8685983
• 负责人: GREGORY B DIETTE
• 金额: $ 18.55万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-03 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8685983
• 关键词: Adult; Adult asthma; Allergens; Appointment; Area; Asthma; Award; Biological Markers; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Childhood; Childhood Asthma; Clinical; Clinical Research; Data; Diet; Disease; Engineering; Environment; Environmental Health; Environmental Protection; Environmental Risk Factor; Epidemiologist; Epidemiology; Faculty; Fellowship; Foundations; Funding; Future; Goals; Grant; Healthcare; Home environment; IgE; Inflammation; Intervention; Joints; Journals; Knowledge; Life; Link; Medicine; Mentored Research Scientist Development Award; Mentors; Morbidity - disease rate; Mus; National Institute of Environmental Health Sciences; National Research Service Awards; Oxidative Stress; Particulate Matter; Peer Review; Pharmaceutical Preparations; Postdoctoral Fellow; Predisposition; Public Health; Public Health Schools; Publications; Race; Recommendation; Research; Research Infrastructure; Research Personnel; Respiratory physiology; Role; Scientist; Source; Time; Translational Research; United States National Institutes of Health; Universities; Variant; base; career; cohort; environmental intervention; inner city; interest; medical schools; member; mortality; patient oriented research; pollutant; professor; programs; stress management

DESCRIPTION (provided by applicant) Dr. Diette is Associate Professor of Medicine at the Johns Hopkins University School of Medicine, where he has joint appointments in Epidemiology and Environmental Health Sciences at the Bloomberg School of Public Health. Since joining the faculty, Dr. Diette has served as mentor to more than 20 trainees, including 14 postdoctoral fellows. With rare exception, his mentees have gone on to highly productive academic careers, garnering honors and receiving NIH grant support (NRSA, K23, R21, R01 U01 and Project Leader on program grants). The majority of his professional life has been dedicated to the conduct of research, presentation and dissemination of findings and establishing a steady base of research funding from the NIH and other sources. The focus of Dr. Diette's career has been on patient-oriented research in asthma, especially race-based health care disparities and environmental determinants of the disease. The main purpose of this K24 proposal is to provide relief from clinical and administrative duties in order to expand the POR program and dedicate additional time and energy to current and future trainees. Thus, the overall aims of this proposal are: Aim 1: To enhance the candidate's capacity to mentor clinician scientists in patient-oriented research; and Aim 2: To expand the candidate's clinical research program in directions that create new scientific opportunities for him and his mentees. Dr. Diette directs the ASTHMA-DIET, a program award examining how diet contributes to asthma susceptibility in children and co-directs the Hopkins DISCOVER program, which investigates mechanisms by which allergens and pollutants provoke inflammation and oxidative stress. These programs are the research homes for his current mentees. These multi-project programs bring together broad scientific expertise from allergists, pulmonologists, adult and pediatric medicine, biostatisticians, epidemiologists, environmental health engineers and others. While substantial evidence now exists for the role of the indoor environment in pediatric asthma, there is insufficient evidence of the biologic mechanisms by which allergens and pollutants may provoke inflammation and oxidative stress in inner city adults. As adults with asthma endure the majority (90%) of mortality attributed to the disease, treatments are inadequate, especially in the area of environmental control. A major focus of this proposal will be to expand the present research program from inner city children to also include inner city adults. The proposed cohort of 100 inner city adults with asthma will examine the extent to which indoor particulate matter provokes oxidative stress and inflammation. With this expansion in the research program, the candidate will provide the foundation for future trials in adults of home-based multi- component environmental interventions, goals which are concordant with the career goals of current mentees and will establish the infrastructure for future mentees with a research interest in adult asthma.

描述（由申请人提供） Diette 博士是约翰霍普金斯大学医学院的医学副教授，并在彭博公共卫生学院的流行病学和环境健康科学领域联合任职。自加入该学院以来，Diette 博士已担任 20 多名学员的导师，其中包括 14 名博士后研究员。 除极少数例外，他的学员都继续了高产的学术生涯，获得了荣誉并获得了 NIH 的资助支持（NRSA、K23、R21、R01 U01 和项目资助项目负责人）。他职业生涯的大部分时间致力于研究、展示和传播研究结果，并从 NIH 和其他来源建立稳定的研究经费基础。 Diette 博士职业生涯的重点是以患者为导向的哮喘研究，特别是基于种族的医疗保健差异和疾病的环境决定因素。该 K24 提案的主要目的是减轻临床和行政职责，以扩大 POR 计划，并为当前和未来的学员投入更多时间和精力。因此，该提案的总体目标是： 目标 1：提高候选人在以患者为导向的研究中指导临床科学家的能力；目标 2：扩大候选人的临床研究项目，为他和他的学员创造新的科学机会。 Diette 博士负责 ASTHMA-DIET 项目，该项目旨在研究饮食如何导致儿童哮喘易感性，并共同负责霍普金斯大学 DISCOVER 项目，该项目研究过敏原和污染物引发炎症和氧化应激的机制。这些项目是他当前学员的研究之家。这些多项目计划汇集了来自过敏科医生、肺科医生、成人和儿科医学、生物统计学家、流行病学家、环境健康工程师等的广泛科学专业知识。虽然现在有大量证据证明室内环境在小儿哮喘中的作用，但没有足够的证据证明过敏原和污染物可能引发内城区成年人炎症和氧化应激的生物机制。 由于患有哮喘的成年人承受着大部分 (90%) 的死亡，因此治疗措施不足，尤其是在环境控制领域。 该提案的一个主要重点是将现有的研究项目从内城儿童扩大到内城成人。拟议的 100 名市中心患有哮喘的成年人队列将检查室内颗粒物引发氧化应激和炎症的程度。 随着研究计划的扩展，候选人将为未来在成人中进行基于家庭的多成分环境干预试验奠定基础，其目标与当前受训者的职业目标一致，并将为未来受训者建立基础设施对成人哮喘的研究兴趣。