Center for Environmental and Health Effects of PFAS

PFAS 环境与健康影响中心

基本信息

批准号：
10115845
负责人：
Erin S Baker
金额：
$ 14.92万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-28 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10115845
关键词：
Address Affect Algorithms Animals Biological Biological Models Blood Carbon Chemicals Communities Core Facility Data Data Collection Data Set Databases Decision Making Development Doctor of Philosophy Education Electron Microscope Electron Microscopy Electron energy loss spectroscopy Ensure Environment Environmental Health Environmental Pollution Evaluation Genomics Hazardous Chemicals Health Human Human Resources Individual Ions Knowledge Laboratories Length Mass Spectrum Analysis Measurement Methods Modernization Molecular Monitor PSSO3 Penetration Phase Phenotype Poly-fluoroalkyl substances Population Procedures Protocols documentation Reaction Reagent Research Research Personnel Resource Sharing Role Sampling Scanning Sex Differences Solid Spectrum Analysis Stable Isotope Labeling Superfund Techniques Technology Tissue Sample Translations Urine Variant Water Work X ray spectroscopy Zebrafish base combinatorial community engagement dashboard detection limit genome sciences high resolution imaging improved innovation instrumentation interest ion mobility lipidomics metabolomics nanometer novel particle remediation species difference tool transcriptome sequencing transcriptomics transmission process

项目摘要

ABSTRACT CAPTURE Responding to newly discovered environmental contaminants requires novel analytical approaches. The Core of Advanced Platform Technologies Used for Remediation and Exploration (CAPTURE) will provide analytical capabilities to the four projects in the NC State Superfund Research Center to enable rapid, comprehensive assessment of PFAS presence. CAPTURE is comprised of the Genomic Sciences Laboratory (GSL), the Analytical Instrumentation Facility (AIF), and the Molecular Education, Technology, and Research Innovation Center (METRIC) at NC State, which have over $25M in modern instrumentation and are operated by more than 20 PhD-level, highly qualified personnel. These capabilities provide CAPTURE with the ability to explore the diversity of scientific questions with a broad range of measurements including RNA-seq, materials characterization, and mass spectrometry analyses for the known and unknown per- and polyfluoroalkyl substances (PFAS). New methods and reagents will result from this work which will enable and inform the entire scientific community about PFAS in the environment. Additionally, CAPTURE will enhance interactions among Center projects and other cores, increasing their impact by ensuring synchronization of exposure measurements and increasing their value in decision-making, translation, and community engagement.

抽象的捕获应对新发现的环境污染物需要新颖的分析方法。用于修复和探索的先进平台技术的核心（CAPTURE）将为北卡罗来纳州超级基金研究中心的四个项目提供分析能力，以实现快速、全面地评估 PFAS 的存在。 CAPTURE 由基因组组成科学实验室 (GSL)、分析仪器设施 (AIF) 和分子教育，北卡罗来纳州立大学技术与研究创新中心 (METRIC)，拥有超过 2500 万美元的现代仪器仪表齐全，由 20 多名博士级高素质人员操作。这些能力为 CAPTURE 提供了广泛探索科学问题多样性的能力测量范围包括 RNA-seq、材料表征和质谱分析分析已知和未知的全氟烷基物质和多氟烷基物质 (PFAS)。新方法和这项工作将产生试剂，这将使整个科学界能够了解环境中的 PFAS。此外，CAPTURE 将增强中心项目和其他核心，通过确保曝光测量的同步来增加其影响提高他们在决策、翻译和社区参与方面的价值。