Affective Sensory Pathways of Light Stroking and Deep Pressure Touch

轻抚和深压触摸的情感感觉通路

• 批准号: 10066400
• 负责人: Laura K Case
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-23 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10066400
• 关键词: Adult; Affect; Affective; Analgesics; Anesthetics; Animals; Anterior; Area; Award; Brain imaging; Brain region; C Fiber; Clinical Research; Complementary Health; Complementary therapies; Data; Disease; Esthesia; Extramural Activities; Fiber; Forearm; Functional Magnetic Resonance Imaging; Funding; Goals; Health; Individual; Insula of Reil; Integrative Medicine; Integrative Therapy; Interdisciplinary Study; Investigation; Knowledge; Lead; Light; Link; Massage; Mechanoreceptors; Mediating; Mental Depression; Mentors; Modality; Monkeys; Moods; Morphine; Muscle; Naloxone; Nerve Block; Neuroanatomy; Opioid; Pain; Pathway interactions; Patients; Perception; Performance; Play; Population; Psychophysics; Recording of previous events; Research; Research Proposals; Research Training; Role; Scientist; Sensory; Skin; Stress; Testing; Therapeutic; Touch sensation; Trauma; Well in self; Work; affective neuroscience; career; career development; chronic pain; chronic pain patient; cingulate cortex; experience; human data; meetings; opioid use; pressure; psychologic; response; sensory mechanism; sensory neuroscience; skills

Project Summary The candidate proposes a career development Pathway to Independence Award to further advance her psychophysical and brain imaging research skills in the area of sensory and affective neuroscience. The candidate's ultimate career goal is to become an independent, extramurally-funded scientist with expertise in affective somatosensation and its role in complementary health modalities. The neuroscience of affective somatosensation is very young and holds large gaps. While an affective-sensory afferent type for light stroking touch is known (the C low threshold mechanoreceptor; C-LTMR), we do not yet understand why deep pressure touch is pleasant, and we understand very little about the role of opioids in affective touch perception. Affective somatosensation is a critical component of numerous complementary and integrative therapies including massage therapy. The purpose of this proposal is to identify the sensory affective pathways of light stroking and deep pressure touch and determine how and why these pathways differ in individuals with chronic pain. Each aim of the proposal is supported by coursework, research training experiences, scientific meetings and seminars, and a detailed research plan. The K99 period of the proposal aims to determine whether the pleasantness of deep pressure touch is dependent on pressure-sensitive C-LTMR afferents in muscle tissue and to determine what role opioids play in the pleasantness of light stroking and deep pressure touch in healthy individuals. The R00 period will determine why individuals with chronic pain show reduced affective sensory processing and altered opioid interactions. The overall goal of this K99/R00 research proposal is to provide the candidate with expertise in sensory affective neuroscience through the performance of psychophysical testing and brain imaging under the guidance of an experienced team of scientists. The candidate is currently a postdoctoral IRTA fellow in the National Center for Complementary and Integrative Health where she is mentored by Dr. M. Catherine Bushnell, a leading expert in pain and affective somatosensation, with access to excellent facilities for conducting nerve blocks, sensory testing, and brain imaging. The findings from the K99/R00 investigations will advance the neuroscience of affective somatosensation by identifying the affective pathways of light stroking and deep pressure touch, enabling research on the functions of these pathways in health and disease as well as in various complementary health modalities including massage.

项目概要 候选人提出职业发展独立之路奖，以进一步提升她的地位 感觉和情感神经科学领域的心理物理学和脑成像研究技能。候选人的 最终的职业目标是成为一名独立的、拥有外部资助的科学家，拥有情感方面的专业知识 体感及其在补充健康方式中的作用。情感躯体感觉的神经科学非常重要 年轻，差距较大。虽然轻抚触摸的情感感觉传入类型是已知的（C低 阈值机械感受器； C-LTMR），我们还不明白为什么深度压力触摸是令人愉快的，但我们明白 关于阿片类药物在情感触觉感知中的作用却知之甚少。情感躯体感觉是一个重要组成部分 许多补充和综合疗法，包括按摩疗法。该提案的目的是确定 轻抚和深压触摸的感觉情感路径并确定这些路径的方式和原因 慢性疼痛患者的情况有所不同。该提案的每个目标都得到课程作业、研究培训的支持 经验、科学会议和研讨会以及详细的研究计划。 K99期提案旨在确定深压触摸的愉悦感是否依赖 对肌肉组织中压力敏感的 C-LTMR 传入进行研究，并确定阿片类药物在愉悦感中发挥的作用 对健康人进行轻抚和深压触摸。 R00 期将决定为什么慢性病患者 疼痛表现出情感感觉处理减少和阿片类药物相互作用改变。本次K99/R00研究的总体目标 建议是通过以下表现为候选人提供感觉情感神经科学方面的专业知识 在经验丰富的科学家团队的指导下进行心理物理测试和脑成像。候选人是 目前是国家补充和综合健康中心的 IRTA 博士后研究员 由疼痛和情感躯体感觉领域的领先专家 M. Catherine Bushnell 博士指导，获得优秀的 用于进行神经阻滞、感官测试和脑成像的设施。 K99/R00 调查结果 将通过识别光抚摸的情感路径来推进情感躯体感觉的神经科学 深度压力触摸，可以研究这些通路在健康和疾病以及各种疾病中的功能 补充健康方式，包括按摩。