Affective Sensory Pathways of Light Stroking and Deep Pressure Touch

轻抚和深压触摸的情感感觉通路

• 批准号: 10615493
• 负责人: Laura K Case
• 金额: $ 21.94万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10615493
• 关键词: Acute Pain; Administrative Supplement; Adult; Affective; Analgesics; Anesthesiology; Anxiety; Area; Attention; Blood; C Fiber; California; Clinical Treatment; Cross-Over Studies; Dorsal; Dose; Double-Blind Method; Emotional; Enrollment; Enzyme-Linked Immunosorbent Assay; Esthesia; Exhibits; Forearm; Fright; Heart Rate; Human; Immunoassay; Individual; Injections; Institutional Review Boards; Insula of Reil; Isotonic Exercise; Lead; Light; Manipulative Therapies; Manuals; Massage; Measures; Mechanics; Mechanoreceptors; Mediating; Mediator of activation protein; Moods; Mus; Nerve; Neurons; Neuropeptides; Nociception; Nociceptors; Opioid Antagonist; Oxytocin; Oxytocin Receptor; Pain; Pain Threshold; Pain intensity; Participant; Pathway interactions; Perception; Peripheral; Placebos; Postoperative Pain; Predictive Factor; Presynaptic Terminals; Process; Research; Rodent; Role; Running; Saline; Sensory; Skin; Spinal Cord; Spinal Ganglia; Stimulus; Stress; Tactile; Testing; Therapeutic tactile stimulation; Touch sensation; Transcranial magnetic stimulation; Universities; autism spectrum disorder; base; chronic pain; chronic pain management; chronic pain patient; coronavirus disease; experience; fibromyalgia patients; injured; innovation; light effects; nerve injury; novel; pain behavior; pain model; pain perception; pain reduction; pain relief; painful neuropathy; peripheral pain; pressure; professor; programs; social; subcutaneous; tactile stimulation; theories; trait

Administrative Supplement Proposal: Abstract R00 AT009466: Affective Sensory Pathways of Light Stroking and Deep Pressure Touch Dr. Case is as an Assistant Professor in the Department of Anesthesiology at the University of California San Diego (UC San Diego). After overcoming covid-related delays, her R00 study on mechanisms of affective touch is running smoothly and on track with her current SARP. The proposed administrative supplement is requested to add two highly innovative aims to increase the impact of the originally proposed study in establishing novel mechanisms of action for sensory-based complementary approaches such as massage therapy. The existing R00 study seeks to identify factors underlying blunted affective touch perception in individuals with chronic pain, and to compare the pain-relieving mechanisms and effects of light gentle stroking and deep pressure between patients with Fibromyalgia (FM) and healthy controls. The current administrative proposal adds two aims: 5) Determine the local effect of subcutaneous OT on experimental pain and 6) Determine the local effect of subcutaneous OT on touch pleasantness. Recent research in rodents demonstrates that oxytocin strongly modulates C-fibers in the spinal cord and at the terminal axon. In humans, systemic oxytocin modulates affective touch perception, and skin injection reduces postsurgical pain. However, peripheral effects of oxytocin on affective touch perception have never been tested in humans. Study results are expected to significantly impact fundamental understanding of the mechanisms of peripheral pathways for touch pleasantness and pain reduction. We expect this project to lead to a competitive R01 submission to test whether local effects of oxytocin differ in patients with chronic pain, who exhibit C-nociceptor sensitization and reduced touch pleasantness. This contribution will inform subsequent research on mechanisms of manual touch therapies and provide a new direction to test differences in individuals with chronic pain.

行政补充提案：摘要 R00 AT009466：轻抚和深压触摸的情感感觉通路 Case 博士是加州大学麻醉学系的助理教授 圣地亚哥（加州大学圣地亚哥分校）。在克服了与新冠病毒相关的延误后，她的 R00 研究机制 情感接触运行顺利，符合她当前的 SARP 的要求。拟议的行政 要求补充增加两个高度创新的目标，以增加原来的影响 拟议的研究建立基于感觉的补充的新作用机制 方法如按摩疗法。现有的 R00 研究旨在确定导致钝化的潜在因素 慢性疼痛患者的情感触觉感知，并比较疼痛缓解机制 纤维肌痛 (FM) 患者与健康人之间轻柔抚摸和深压的影响 控制。当前的行政提案增加了两个目标： 5) 确定当地的影响 皮下 OT 对实验疼痛的影响 6) 确定皮下 OT 对实验疼痛的局部影响 触摸愉悦感。最近对啮齿动物的研究表明，催产素强烈调节 C 纤维 位于脊髓和末端轴突。在人类中，全身催产素调节情感触摸 知觉，皮肤注射可减轻术后疼痛。然而，催产素的外周作用 情感触觉感知从未在人类身上进行过测试。研究结果预计将显着 影响对触觉愉悦感的外周通路机制的基本理解 减少疼痛。我们预计该项目将导致有竞争力的 R01 提交，以测试是否有局部影响 慢性疼痛患者的催产素水平不同，他们表现出 C 伤害感受器敏感性和触摸减少 愉快。这一贡献将为后续关于手动触摸疗法机制的研究提供信息 并为测试慢性疼痛个体的差异提供新的方向。

项目成果

Chronic pain patients low in social connectedness report higher pain and need deeper pressure for pain relief.

社会联系较低的慢性疼痛患者报告疼痛程度更高，需要更大的压力来缓解疼痛。

• 发表时间: 2023-12
• 作者: Baumgartner, Jennifer N;Haupt, Michael R;Case, Laura K
• 通讯作者: Case, Laura K

Pleasant Deep Pressure: Expanding the Social Touch Hypothesis.

令人愉快的深层压力：扩展社交接触假说。

• 发表时间: 2021
• 影响因子: 3.3
• 作者: Case, Laura K;Liljencrantz, Jaquette;McCall, Micaela V;Bradson, Megan;Necaise, Aaron;Tubbs, Justin;Olausson, Håkan;Wang, Binquan;Bushnell, M Catherine
• 通讯作者: Bushnell, M Catherine

Widespread Pressure Delivered by a Weighted Blanket Reduces Chronic Pain: A Randomized Controlled Trial.

加重毯子提供的广泛压力可减轻慢性疼痛：一项随机对照试验。

• 发表时间: 2022
• 作者: Baumgartner, Jennifer N;Quintana, Desiree;Leija, Linda;Schuster, Nathaniel M;Bruno, Kelly A;Castellanos, Joel P;Case, Laura K
• 通讯作者: Case, Laura K

The Role of Expectations and Endogenous Opioids in Mindfulness-Based Relief of Experimentally Induced Acute Pain.

期望和内源性阿片类药物在基于正念缓解实验引起的急性疼痛中的作用。

• 发表时间: 2021-07-01
• 影响因子: 3.3
• 作者: Case, Laura;Adler;Wells, Rebecca E;Zeidan, Fadel
• 通讯作者: Zeidan, Fadel

Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans.

无害的压力感觉需要 A 型传入神经，但不需要人类功能性的 ΡΪÎÎÎ2 通道。

• 发表时间: 2021
• 影响因子: 16.6
• 作者: Case, Laura K;Liljencrantz, Jaquette;Madian, Nicholas;Necaise, Aaron;Tubbs, Justin;McCall, Micaela;Bradson, Megan L;Szczot, Marcin;Pitcher, Mark H;Ghitani, Nima;Frangos, Eleni;Cole, Jonathan;Bharucha;Saade, Dimah;Ogata, Tracy
• 通讯作者: Ogata, Tracy