IDEA

主意

• 批准号: 8167018
• 负责人: Stephen P Messier
• 金额: $ 33.52万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167018
• 关键词: Adult; Age; American; Arthritis; Biological Markers; Body Weight decreased; Clinical; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Disease Pathway; Disease Progression; Dose; Exercise; Funding; Grant; Inflammation; Inflammatory; Institution; Intervention; Knee; Knee Osteoarthritis; Knee joint; Mediator of activation protein; Obesity; Outcome; Overweight; Pain; Participant; Patient Self-Report; Population; Population Study; Prevalence; Randomized; Research; Research Personnel; Resources; Risk; Source; Stimulus; Time; United States National Institutes of Health; dietary restriction; intervention effect; joint loading; quadriceps muscle; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis (OA) is the most common form of arthritis with a prevalence conservatively estimated at 21 million Americans, or 12.1% of the adult population. We recently showed that a 5% weight loss in obese adults with knee OA had a modest effect on clinical outcomes; however, these participants remained obese at the conclusion of the intervention, so their risk of disease progression was not altered. We hypothesize that a more intensive weight loss (2 to 3 times greater than previously achieved in this population) would provide the stimulus necessary to reduce inflammation and joint loads and alter disease progression. The study population will consist of 450 overweight and obese, older (age = 60 yrs) adults with tibiofemoral osteoarthritis of one or both knees. Participants will be randomized to 1 of 3, 18-month interventions: intensive dietary restriction-plus-exercise; exercise-only; or intensive dietary restriction-only. The primary aim is to compare the effects of these interventions on inflammatory biomarkers and knee joint loads in overweight and obese adults with knee OA. Secondary aims are: to compare the effects of these interventions on self-reported function and pain, and mobility; to determine the dose response to weight loss on disease progression and the mechanisms associated with the OA disease pathway; to determine if inflammatory biomarkers and knee joint loads are mediators of the interventions, with significant effects on function, pain, and disease progression and to determine the association between quadriceps strength and disease progression as a function of knee alignment.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 骨关节炎（OA）是关节炎的最常见形式，保守估计为2100万美国人，占成年人口的12.1％。我们最近表明，膝盖OA的肥胖成年人体重减轻了5％，对临床结局具有适度的影响。但是，这些参与者在干预结束时仍然肥胖，因此他们的疾病进展风险没有改变。我们假设体重减轻（比以前在该人群中大的2至3倍）将提供减少炎症和关节负荷并改变疾病进展所必需的刺激。 该研究人群将包括450个超重和肥胖，年龄较大（年龄= 60岁）的成年人患有胫骨骨关节炎。参与者将被随机分为3个，18个月的干预措施中的1个：密集的饮食限制加强运动；仅运动；或仅饮食限制。主要目的是比较这些干预措施对具有膝关节OA的超重和肥胖成年人的炎症生物标志物和膝关节负荷的影响。次要目的是：比较这些干预措施对自我报告的功能和痛苦以及流动性的影响；确定对疾病进展的体重减轻的剂量反应以及与OA疾病途径相关的机制；为了确定炎症性生物标志物和膝关节负荷是否是干预措施的介体，对功能，疼痛和疾病进展产生重大影响，并确定股四头肌强度和疾病进展之间的关联是膝关节比对的函数。