FATTY ACIDS, ARTHRITIS, AND INFLAMMATION IN THE ELDERLY

老年人的脂肪酸、关节炎和炎症

• 批准号: 7951411
• 负责人: Stephen P Messier
• 金额: $ 3.36万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951411
• 关键词: Adipocytes; Affect; Anti-Inflammatory Agents; Anti-inflammatory; Arthritis; Blood; Blood Circulation; Cartilage; Chronic Disease; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Diet; Diffuse; Disease Progression; Eicosapentaenoic Acid; Elderly; Fatty Acids; Funding; Grant; Inflammation; Inflammatory; Institution; Interleukin-6; Joints; Knee; Measures; Mediating; Normal Range; Obesity; Omega-3 Fatty Acids; Pain; Patient Self-Report; Pharmaceutical Preparations; Physical Function; Placebos; Polyunsaturated Fatty Acids; Population; Research; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Risk Factors; Role Concepts; Source; TNF gene; Tissues; United States National Institutes of Health; Weight-Bearing state; adipokines; bone metabolism; cytokine; gamma-Linolenic Acid; inflammatory marker; primary outcome; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis (OA) is the most common rheumatic disease and the knee is the most often affected weight-bearing joint. While there are no cures for OA, obesity is a major risk factor. The modern concept of the role of obesity in chronic disease progression relates to a systemic low-grade pro-inflammatory state mediated by cytokines and adipokines produced by fat cells. An increase in omega-3 fatty acids in the diet decreases inflammation in rheumatoid arthritis. The use of omega-3 fatty acids consistently shows modest clinical improvements and a reduction in non-steroidal anti-inflammatory drugs in this population. We hypothesize that supplementing with the polyunsaturated fatty acids eicosapentaenoic acid (EPA) and gamma-linolenic acid (GLA) will significantly decrease the level of inflammatory cytokines in the blood when compared to a placebo. Even levels on the high end of normal values can negatively affect cartilage and bone metabolism. With their small size (less than 15kDa), cytokines can readily diffuse from the systemic circulation into the joint space to act on joint tissues. Our primary outcomes will be measures of markers of inflammation, the inflammatory cytokines CRP, IL-6, TNF?, and the soluble receptor sTNFR1. Secondary measures will include mobility, self-reported physical function, and pain.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 骨关节炎＆＃40; OA＆＃41;是最常见的风湿性疾病，膝盖是最经常受影响的体重关节。虽然没有OA治疗方法，但肥胖是主要的危险因素。肥胖症在慢性疾病进展中作用的现代概念与由脂肪细胞产生的细胞因子和脂肪因子介导的全身性低度促炎状态有关。 饮食中omega-3脂肪酸的增加会降低类风湿关节炎的炎症。 omega-3脂肪酸的使用始终显示出适度的临床改善和该人群中非甾体类抗炎药的减少。我们假设补充多不饱和脂肪酸eicosapentaenoic酸EPA＆＃41;和γ-中的烯醇酸GLA＆＃41;与安慰剂相比，血液中炎症细胞因子的水平将显着降低。即使是正常值的高端的水平也会对软骨和骨代谢产生负面影响。由于其小于15KDA的小尺寸，细胞因子可以很容易地从全身循环中扩散到关节空间中，以在关节组织上作用。我们的主要结果将是炎症，炎症细胞因子CRP，IL-6，TNF？和可溶性受体STNFR1的标记措施。次要措施将包括移动性，自我报告的身体机能和疼痛。