DIETARY FRUCTOSE AND URINARY OXALATE EXCRETION

膳食果糖和尿草酸盐排泄

基本信息

批准号：
8167038
负责人：
ROSS P HOLMES
金额：
$ 6.92万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-01 至 2011-02-28
项目状态：
已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Kidney stone disease is a prevalent medical condition that afflicts 10% of Caucasian males at some point in their lifetime with 80% of these stones being predominately calcium oxalate. The amount of oxalate excreted in urine is an important risk factor for stone formation and is derived about equally from dietary intake and endogenous synthesis. The endogenous synthesis of oxalate results from the metabolism of sugars and amino acids and occurs primarily in the liver. Fructose consumption was recently identified as a risk factor for stone formation. Subjects were divided into quintiles and received between 5.6% and 15.2% of their energy as fructose. Several lines of evidence indicate that fructose metabolism results in greater synthesis of oxalate than from the metabolism of glucose. With isolated rat hepatocytes, Rofe et el reported that at sugar concentrations of 10mM, fructose produced 10 times more oxalate than glucose. We have recently observed in preliminary, unpublished experiments that cultured human hepatocytes synthesize 3 times as much oxalate when growing in media containing fructose compared with media containing glucose.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。肾结石是一种普遍的医学疾病，在其一生中的某个时刻折磨了10％的高加索男性，其中80％的石头主要是草酸钙。在尿液中排泄的草酸盐量是石材形成的重要危险因素，并且均来自饮食摄入和内源性合成。草酸盐的内源性合成是由糖和氨基酸的代谢产生的，主要发生在肝脏中。果糖消耗最近被确定为石材形成的危险因素。将受试者分为五分之一，并将其作为果糖的能量的5.6％至15.2％。几条证据表明，与葡萄糖的代谢相比，果糖代谢会导致草酸盐的合成更大。 Rofe et el伴有分离的大鼠肝细胞，报道说，在10mm的糖浓度下，果糖产生的草酸盐含量是葡萄糖的10倍。我们最近在初步的未发表的实验中观察到，与含有葡萄糖的培养基相比，在含有果糖的培养基中生长时，培养的人肝细胞合成了三倍。