INFLUENCE OF GLYCINE BLOOD CONCENTRATION ON ITS METABOLISM TO OXALATE

甘氨酸血液浓度对其草酸盐代谢的影响

• 批准号: 8167055
• 负责人: ROSS P HOLMES
• 金额: $ 1.9万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167055
• 关键词: Accounting; Blood; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Glycine; Grant; Human; Individual; Institution; Metabolic Pathway; Metabolism; Normal Range; Oxalates; Plasma; Production; Reporting; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Urine; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research performed 4 decades ago reported that a metabolic pathway where glycine was converted to oxalate, accounted for 40% of the oxalate in human urine. We recently tested the conversion of 13C-glycine to urinary oxalate in healthy subjects infused with 13C-glycine to acheive a 4% enrichment in plasma glycine. This study revealed that that the conversion of glycine to oxalate, if any, was 10%. To determine if there is a significant metabolic pathway, 6 subjects will be infused with 13C-glycine to produce a 40% enrichment of plasma 13C-glycine. In most subjects the plasma glycine level should still be within the normal range. This enrichment will enable us to determine if more than 1% of glycine is converted to oxalate. This research is important in understanding the origins of endogenous oxalate production and in identifying strategies to decrease it in individuals with oxalate-related disorders.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 4 年前进行的研究报告称，甘氨酸转化为草酸盐的代谢途径占人体尿液中草酸盐的 40%。我们最近在健康受试者中测试了 13C-甘氨酸向尿草酸盐的转化，健康受试者输注了 13C-甘氨酸，血浆甘氨酸富集了 4%。这项研究表明，甘氨酸转化为草酸盐（如果有的话）的转化率为 10%。为了确定是否存在显着的代谢途径，将向 6 名受试者输注 13C-甘氨酸，以产生 40% 的血浆 13C-甘氨酸富集。在大多数受试者中，血浆甘氨酸水平仍应在正常范围内。这种富集将使我们能够确定是否有超过 1% 的甘氨酸转化为草酸盐。这项研究对于了解内源性草酸盐产生的起源以及确定减少草酸盐相关疾病个体的内源性草酸盐产生的策略非常重要。