Aerobic Exercise to Improve Outcomes of Treatment for Methamphetamine Dependence

有氧运动可改善甲基苯丙胺依赖的治疗效果

• 批准号: 8134454
• 负责人: RICHARD A RAWSON
• 金额: $ 51.77万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8134454
• 关键词: Address; Aerobic Exercise; Affective; Anhedonia; Anxiety; Behavior; Behavior Therapy; Behavioral; Blood Pressure; Brain; Brain imaging; Caring; Cholesterol; Clinical; Cognition; Consent; Control Groups; Crime; Data; Data Quality; Disease; Dopamine; Drug abuse; Drug usage; Education; Employment; Enrollment; Evaluation; Exclusion; Exercise; Frequencies; Goals; HIV; Health; Health education; Image; Incentives; Individual; Infection; Intervention; Measures; Medical; Mental Depression; Methamphetamine; Methamphetamine dependence; National Institute of Drug Abuse; Neurocognitive; Outcome; Participant; Patient Self-Report; Pharmaceutical Preparations; Pharmacotherapy; Physical activity; Population; Preclinical Drug Evaluation; Prevention; Protocols documentation; Public Health; Randomized; Recovery; Relapse; Research; Residential Treatment; Risk; Sampling; Science; Sex Behavior; Social Behavior; Stress; Symptoms; Treatment outcome; Urine; Variant; Weight; addiction; base; craving; design; evidence base; follow-up; high risk sexual behavior; improved; innovation; meetings; post intervention; prevent; programs; public health relevance; receptor; remediation; response; social; transmission process; treatment as usual; treatment program; treatment response; treatment strategy

DESCRIPTION (provided by applicant): This five-year study will assemble data on the efficacy of aerobic exercise for the treatment of methamphetamine dependence in a population of 150 individuals seeking treatment at Cri-Help residential drug treatment program in Los Angles. After signing consent and satisfying all inclusion/exclusion requirements, participants will be enrolled into the study and undergo baseline assessments during approximately two weeks of treatment as usual. After randomization, participants will enter the Exercise condition (n=75) or the control (Health Education; n=75) condition for an 8-week intervention duration. Incentives for participation in either condition activity (thrice weekly) are fixed at $10 per session. Of the 150 total participants, 30 voluntary participants will be part of a brain imaging substudy. The objective of the imaging substudy is to determine possible brain mechanisms associated with hypothesized effects of exercise on treatment outcomes. The primary goal of the study is to rigorously and comprehensively determine whether inclusion of a aerobic exercise within a residential program improves treatment outcomes in terms of reduced methamphetamine use during the first 12 weeks post discharge and 26 week follow up, as well as to characterize effects of exercise on health, psychiatric symptoms and cognition compared to the control (education) group pre/post intervention. Aims of the study are: Aim 1. To characterize effects of an aerobic exercise intervention ("Exercise") compared to health education ("Education") in terms of drug use after discharge from residential drug treatment in a population of MA- dependent individuals. Aim 2. To characterize effects of Exercise on MA craving and negative affective states including anxiety, depression, anhedonia, and stress reactivity among participants in residential treatment for MA dependence. Aim 3. To characterize effects of Exercise on neurocognitive functioning. Aim 4. To characterize variations in health-related outcomes among participants in the Exercise condition compared with those in the Education condition. Aim 5. To examine changes in dopamine D2/D3 receptor availability in abstinent MA-dependent participants assigned to an Exercise group compared to a subsample of participants in an Education (control) group (n = 15 per group). Aim 6. To examine differences in addiction-related behaviors (per ASI-type measures) according to intervention condition. There is a critical need for systematic evaluation of strategies for treating methamphetamine use disorders. Thus, this project responds to NIDA request (RFA-DA-09-013) to develop and evaluate an effective exercise-based intervention for addiction. PUBLIC HEALTH RELEVANCE: The proposed research is of considerable public health significance in that it will provide foundational information on aerobic exercise as an intervention for methamphetamine dependence, a serious drug problem with extensive impacts. If proven effective, the protocol could be useful in treating addiction and in reducing methamphetamine use among treated individuals, thereby efficiently reducing drug abuse and related consequences such as criminal activity, social disruption, and elevated risk of HIV transmission/infection due to increased frequency of unsafe sexual activities while on methamphetamine. The proposed project will determine clinical utility of an innovative intervention protocol previously untested in MA-dependent individuals.

描述（由申请人提供）：这项为期五年的研究将收集有氧运动对在洛杉矶 Cri-Help 住院药物治疗项目寻求治疗的 150 名个体的甲基苯丙胺依赖性治疗效果的数据。在签署同意书并满足所有纳入/排除要求后，参与者将被纳入研究，并在大约两周的治疗期间像往常一样接受基线评估。随机分组后，参与者将进入运动条件（n=75）或控制（健康教育；n=75）条件，为期 8 周的干预持续时间。参加任一条件活动（每周三次）的奖励固定为每次 10 美元。在 150 名参与者中，有 30 名自愿参加脑成像子研究。成像子研究的目的是确定与运动对治疗结果的假设影响相关的可能的大脑机制。该研究的主要目标是严格、全面地确定在住院治疗计划中纳入有氧运动是否可以改善出院后前 12 周和 26 周随访期间减少甲基苯丙胺使用的治疗结果，并描述效果与干预前/干预后的对照组（教育）组相比，运动对健康、精神症状和认知的影响。该研究的目的是： 目标 1. 比较有氧运动干预（“运动”）与健康教育（“教育”）对 MA 依赖个体群体从住院药物治疗出院后药物使用的影响。目标 2. 表征运动对 MA 依赖住院治疗参与者的 MA 渴望和负面情感状态（包括焦虑、抑郁、快感缺乏和压力反应性）的影响。目标 3. 表征运动对神经认知功能的影响。目标 4. 描述运动条件下参与者与教育条件下参与者之间健康相关结果的差异。目标 5. 检查分配到运动组的戒断 MA 依赖参与者与教育（对照组）参与者子样本（每组 n = 15）相比，多巴胺 D2/D3 受体可用性的变化。目标 6. 根据干预条件检查成瘾相关行为（按照 ASI 类型测量）的差异。迫切需要对治疗甲基苯丙胺使用障碍的策略进行系统评估。因此，该项目响应 NIDA 的请求 (RFA-DA-09-013)，开发和评估有效的基于运动的成瘾干预措施。 公共健康相关性：拟议的研究具有相当大的公共健康意义，因为它将提供有氧运动作为甲基苯丙胺依赖干预措施的基础信息，甲基苯丙胺依赖是一种影响广泛的严重毒品问题。如果被证明有效，该方案可用于治疗成瘾和减少接受治疗的个人使用甲基苯丙胺，从而有效减少药物滥用和相关后果，例如犯罪活动、社会混乱以及由于吸毒频率增加而增加的艾滋病毒传播/感染风险。服用甲基苯丙胺期间发生不安全的性行为。拟议的项目将确定之前未在 MA 依赖个体中测试过的创新干预方案的临床效用。