Aerobic Exercise to Improve Outcomes of Treatment for Methamphetamine Dependence

有氧运动可改善甲基苯丙胺依赖的治疗效果

• 批准号: 8896282
• 负责人: RICHARD A RAWSON
• 金额: $ 11.34万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8896282
• 关键词: Address; Aerobic Exercise; Affective; Anhedonia; Anxiety; Behavior; Behavior Therapy; Behavioral; Blood Pressure; Brain; Brain imaging; Caring; Cholesterol; Clinical; Cognition; Consent; Control Groups; Crime; Data; Data Quality; Disease; Dopamine; Drug abuse; Drug usage; Education; Employment; Enrollment; Evaluation; Exclusion; Exercise; Frequencies; Goals; HIV; Health; Health education; Image; Incentives; Individual; Infection; Intervention; Measures; Medical; Mental Depression; Methamphetamine; Methamphetamine dependence; National Institute of Drug Abuse; Neurocognitive; Outcome; Participant; Patient Self-Report; Pharmaceutical Preparations; Pharmacotherapy; Physical activity; Population; Preclinical Drug Evaluation; Prevention; Protocols documentation; Public Health; Randomized; Recovery; Relapse; Research; Residential Treatment; Risk; Sampling; Science; Sex Behavior; Social Behavior; Stress; Symptoms; Treatment outcome; Urine; Variant; Weight; abstracting; addiction; base; craving; design; drug abuse prevention; evidence base; follow-up; high risk sexual behavior; improved; innovation; meetings; post intervention; programs; receptor; remediation; response; social; transmission process; treatment as usual; treatment program; treatment response; treatment strategy

Project Summary/Abstract Description of the Project: This five-year study will assemble data on the efficacy of aerobic exercise for the treatment of methamphetamine dependence in a population of 150 individuals seeking treatment at Cri-Help residential drug treatment program in Los Angles. After signing consent and satisfying all inclusion/exclusion requirements, participants will be enrolled into the study and undergo baseline assessments during approximately two weeks of treatment as usual. After randomization, participants will enter the Exercise condition (n=75) or the control (Health Education; n=75) condition for an 8-week intervention duration. Incentives for participation in either condition activity (thrice weekly) are fixed at $10 per session. Of the 150 total participants, 30 voluntary participants will be part of a brain imaging substudy. The objective of the imaging substudy is to determine possible brain mechanisms associated with hypothesized effects of exercise on treatment outcomes. The primary goal of the study is to rigorously and comprehensively determine whether inclusion of a aerobic exercise within a residential program improves treatment outcomes in terms of reduced methamphetamine use during the first 12 weeks post discharge and 26 week follow up, as well as to characterize effects of exercise on health, psychiatric symptoms and cognition compared to the control (education) group pre/post intervention. Aims of the study are: Aim 1. To characterize effects of an aerobic exercise intervention ("Exercise") compared to health education ("Education") in terms of drug use after discharge from residential drug treatment in a population of MA- dependent individuals. Aim 2. To characterize effects of Exercise on MA craving and negative affective states including anxiety, depression, anhedonia, and stress reactivity among participants in residential treatment for MA dependence. Aim 3. To characterize effects of Exercise on neurocognitive functioning. Aim 4. To characterize variations in health-related outcomes among participants in the Exercise condition compared with those in the Education condition. Aim 5. To examine changes in dopamine D2/D3 receptor availability in abstinent MA-dependent participants assigned to an Exercise group compared to a subsample of participants in an Education (control) group (n = 15 per group). Aim 6. To examine differences in addiction-related behaviors (per ASI-type measures) according to intervention condition. There is a critical need for systematic evaluation of strategies for treating methamphetamine use disorders. Thus, this project responds to NIDA request (RFA-DA-09-013) to develop and evaluate an effective exercise-based intervention for addiction.

项目概要/摘要 项目描述：这项为期五年的研究将收集有氧运动功效的数据 在 Cri-Help 寻求治疗的 150 名患者中治疗甲基苯丙胺依赖 洛杉矶的住院戒毒治疗计划。签署同意书并满足所有包含/排除条件后 要求，参与者将被纳入研究并在期间接受基线评估 照常治疗大约两周。随机分组后，参与者将进入练习 条件（n=75）或对照（健康教育；n=75）条件，为期 8 周的干预持续时间。 参加任一条件活动（每周三次）的奖励固定为每次 10 美元。 150 名中 总共有 30 名自愿参与者将参加脑成像子研究。该计划的目标 成像子研究是为了确定与假设的运动效果相关的可能的大脑机制 关于治疗结果。该研究的主要目标是严格、全面地确定是否 将有氧运动纳入住院治疗计划可改善治疗效果，减少 出院后前 12 周和 26 周随访期间使用甲基苯丙胺，以及 与对照组相比，描述运动对健康、精神症状和认知的影响 （教育）小组干预前/干预后。该研究的目的是： 目标 1. 与健康教育相比，描述有氧运动干预（“运动”）的效果 （“教育”）在 MA- 人群中从住院戒毒治疗出院后的吸毒情况 依赖个人。 目标 2. 表征运动对 MA 渴望和负面情感状态（包括焦虑、 MA 依赖住院治疗参与者的抑郁、快感缺失和应激反应。 目标 3. 表征运动对神经认知功能的影响。 目标 4. 描述运动条件下参与者之间健康相关结果的差异 与教育条件下的人相比。 目标 5. 检查戒断 MA 依赖的参与者中多巴胺 D2/D3 受体可用性的变化 分配到锻炼组的参与者与教育（对照组）组参与者的子样本进行比较（n = 每组 15 名）。 目标 6. 根据以下标准检查成瘾相关行为的差异（按照 ASI 类型测量） 干预条件。 迫切需要对治疗甲基苯丙胺使用的策略进行系统评估 失调。因此，该项目响应 NIDA 的请求 (RFA-DA-09-013)，开发和评估有效的 基于运动的成瘾干预。

项目成果

The Impact of Exercise On Depression and Anxiety Symptoms Among Abstinent Methamphetamine-Dependent Individuals in A Residential Treatment Setting.

• DOI: 10.1016/j.jsat.2015.04.007
• 发表时间: 2015-10
• 期刊: Journal of substance abuse treatment
• 影响因子: 3.9
• 作者: Rawson RA;Chudzynski J;Gonzales R;Mooney L;Dickerson D;Ang A;Dolezal B;Cooper CB
• 通讯作者: Cooper CB

Eight weeks of exercise training improves fitness measures in methamphetamine-dependent individuals in residential treatment.

• DOI: 10.1097/adm.0b013e318282475e
• 发表时间: 2013-03
• 期刊: Journal of addiction medicine
• 影响因子: 5.5
• 作者: Dolezal BA;Chudzynski J;Storer TW;Abrazado M;Penate J;Mooney L;Dickerson D;Rawson RA;Cooper CB
• 通讯作者: Cooper CB

Impact of an exercise intervention on methamphetamine use outcomes post-residential treatment care.

• DOI: 10.1016/j.drugalcdep.2015.08.029
• 发表时间: 2015-11-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Rawson RA;Chudzynski J;Mooney L;Gonzales R;Ang A;Dickerson D;Penate J;Salem BA;Dolezal B;Cooper CB
• 通讯作者: Cooper CB

Exercise for methamphetamine dependence: rationale, design, and methodology.

甲基苯丙胺依赖练习：基本原理、设计和方法。

• DOI: 10.1016/j.cct.2013.11.010
• 发表时间: 2014
• 期刊: Contemporary clinical trials
• 影响因子: 2.2
• 作者: Mooney,LarissaJ;Cooper,Christopher;London,EdytheD;Chudzynski,Joy;Dolezal,Brett;Dickerson,Daniel;Brecht,Mary-Lynn;Peñate,Jose;Rawson,RichardA
• 通讯作者: Rawson,RichardA

Craving among individuals with stimulant use disorder in residential social model-based treatment - Can exercise help?

患有兴奋剂使用障碍的个体对基于住院社会模式的治疗的渴望 - 运动有帮助吗？

• DOI: 10.1016/j.drugalcdep.2021.109247
• 发表时间: 2022
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Salem,BilalA;Gonzales-Castaneda,Rachel;Ang,Alfonso;Rawson,RichardA;Dickerson,Daniel;Chudzynski,Joy;Penate,Jose;Dolezal,Brett;Cooper,ChristopherB;Mooney,LarissaJ
• 通讯作者: Mooney,LarissaJ