Quantitative Biology: a Graduate Curriculum Linking the Physical and Biomedical S

定量生物学：连接物理和生物医学的研究生课程

• 批准号: 8091241
• 负责人: JEFF GELLES
• 金额: $ 25.37万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8091241
• 关键词: Biology; Educational Curriculum; Link

DESCRIPTION (provided by applicant): The second half of the last century produced a staggering wealth of information about the cellular and molecular processes of life. The quantity and quality of this data is ushering in a new mode of thinking in the biomedical sciences that relies heavily on mathematical and computational tools and on rigorous quantitative experimental methods. With increasing frequency, the analytical tools and experimental methods are not home grown within the life sciences, but are adopted from research in the physical sciences. This brave new world requires a new kind of researcher, one who easily moves between the bench and the workstation, one who is equally at ease with running microscopes as with running simulations, and one for whom building quantitative models and testing them by designing equally quantitative experiments comes naturally. The Quantitative Biology (QB) Program at Brandeis University brings together six different Ph.D. programs from four science departments in order to train students who can rise to this interdisciplinary challenge. QB is an official interdepartmental graduate program at Brandeis that has just completed its second full academic year of operation; the program currently has 21 enrolled students. QB leverages the strengths of existing disciplinary Ph.D. programs at Brandeis by bringing together students from these programs in a specialized curriculum that is designed to take advantage of the learning opportunities afforded by training in multi-disciplinary groups. Students admitted to graduate study in the Biochemistry, Biophysics & Structural Biology, Chemistry, Molecular & Cellular Biology, Neuroscience, or Physics Ph.D. programs and who choose the QB track will, upon successful completion, receive a Ph.D. degree in their chosen discipline "with an additional specialization in Quantitative Biology". This approach provides the students with modern discipline-bridging training while providing the graduate with a Ph.D. credential that has proven value on the job market because it is in a recognized traditional discipline. Students typically enter the QB program in either the first or second years of their Ph.D. studies and remain affiliated with QB until they graduate. Each student selected for support by the training grant will be supported during years 2 and 3 of their studies. RELEVANCE: The goal of the Quantitative Biology program is to train Ph.D. scientists who are well equipped to bring quantitative experimental, computational, and mathematical methods from Physics and Chemistry to bear on important problems in biomedical research. It is anticipated that the work of these scientists will lead to improvements in public health by advancing basic research in directions that are not readily accessible to scientists who lack interdisciplinary training.

描述（由申请人提供）：上个世纪下半叶产生了有关细胞和分子生命过程的惊人信息。这些数据的数量和质量正在以严重依赖数学和计算工具以及严格的定量实验方法的生物医学科学的新思维方式引入。随着频率的越来越多，分析工具和实验方法不是生命科学中种植的家园，而是从物理科学的研究中采用的。这个勇敢的新世界需要一种新型的研究人员，他们很容易在板凳和工作站之间移动，他们与运行模拟同样轻松地进行了跑步模拟，并且为他们建立定量模型并通过设计同样定量的实验来进行测试。布兰代斯大学的定量生物学（QB）计划汇集了六个不同的博士学位。来自四个科学部门的课程，以培训可以提出这一跨学科挑战的学生。 QB是Brandeis的官方跨部门研究生课程，刚刚完成了第二个整个学年的运作；该计划目前有21名入学学生。 QB利用 现有纪律博士的优势通过将这些学生从这些中召集在一起，在布兰代斯的计划 专业课程中的课程旨在利用多学科小组的培训提供的学习机会。学生接受了生物化学，生物物理学和结构生物学，化学，分子和细胞生物学，神经科学或物理学博士学位的研究生研究。程序和选择QB轨道的人将在成功完成后获得博士学位。他们所选学科的学位“具有定量生物学方面的额外专业化”。这种方法为学生提供了现代学科的桥梁培训，同时为毕业生提供博士学位。在就业市场上具有证明价值的证书，因为它处于公认的传统学科。学生通常在博士学位的第一年或第二年中输入QB计划。研究并一直隶属于QB，直到他们毕业。在他们的研究的第2年和第3年中，将支持每个培训赠款支持的学生。 相关性：定量生物学计划的目标是培训博士学位。能够从物理和化学带来定量实验，计算和数学方法的科学家，以解决生物医学研究中的重要问题。可以预料，这些科学家的工作将通过在缺乏跨学科培训的科学家不容易获得的方向上推进基础研究来改善公共卫生。