A Chicago Biomedical Consortium Hub of Innovative Technologies for Entrepreneurship and Science (CBC - HITES)

芝加哥生物医学联盟创业与科学创新技术中心 (CBC - HITES)

• 批准号: 10783500
• 负责人: SATISH N NADIG
• 金额: $ 99.99万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-25 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10783500
• 关键词: Active Learning; Address; Area; Award; Biological Products; Biological Sciences; Biotechnology; Businesses; Capital; Cell Therapy; Chicago; Cities; Clinical; Clinical Trials; Clinical and Translational Science Awards; Community Physician; Development; Discipline; Doctor of Philosophy; Ecosystem; Educational Curriculum; Engineering; Ensure; Entrepreneurship; Equity; Evaluation; Familiarity; Feedback; Funding; Funding Agency; Human Resources; Illinois; Industry; Infrastructure; Institution; Investments; Joints; Knowledge; Leadership; Link; Marketing; Medicine; Methods; Modality; Nanotechnology; Nature; Occupations; Pharmaceutical Preparations; Philanthropic Fund; Physicians; Process; Protein Engineering; Request for Applications; Research; Research Contracts; Research Personnel; Resources; Science; Scientist; Service delivery model; Services; Societies; Spottings; Supervision; Surgeon; Talents; Technology; Therapeutic; Time; Training; Translating; Translations; Triage; Universities; Validation; Work; clinical implementation; clinical translation; cohort; commercialization; experience; experimental study; gene therapy; health care service organization; implementation science; innovation; innovative technologies; interest; invention; manufacture; metropolitan; novel diagnostics; novel therapeutics; operation; programs; recruit; research clinical testing; science teacher; small molecule; synthetic biology; Active Learning; Address; Area; Award; Biological Products; Biological Sciences; Biotechnology; Businesses; Capital; Cell Therapy; Chicago; Cities; Clinical; Clinical Trials; Clinical and Translational Science Awards; Community Physician; Development; Discipline; Doctor of Philosophy; Ecosystem; Educational Curriculum; Engineering; Ensure; Entrepreneurship; Equity; Evaluation; Familiarity; Feedback; Funding; Funding Agency; Human Resources; Illinois; Industry; Infrastructure; Institution; Investments; Joints; Knowledge; Leadership; Link; Marketing; Medicine; Methods; Modality; Nanotechnology; Nature; Occupations; Pharmaceutical Preparations; Philanthropic Fund; Physicians; Process; Protein Engineering; Request for Applications; Research; Research Contracts; Research Personnel; Resources; Science; Scientist; Service delivery model; Services; Societies; Spottings; Supervision; Surgeon; Talents; Technology; Therapeutic; Time; Training; Translating; Translations; Triage; Universities; Validation; Work; clinical implementation; clinical translation; cohort; commercialization; experience; experimental study; gene therapy; health care service organization; implementation science; innovation; innovative technologies; interest; invention; manufacture; metropolitan; novel diagnostics; novel therapeutics; operation; programs; recruit; research clinical testing; science teacher; small molecule; synthetic biology

PROJECT SUMMARY With three R1 universities and multiple research institutions, the Chicago Metropolitan Statistical Area is awash with academic innovation but needs to attract more early-stage biopharma specific capital and more “bio- entrepreneurs” trained to link university-based projects to the know-how and funding that can launch a biomedical application into the emerging ecosystem. The Chicago Biomedical Consortium (CBC), a philanthropically funded research consortium between the University of Illinois Chicago (UIC), the University of Chicago (UC), and Northwestern University (NU) was founded in 2006, reimagined in 2016, and renewed in 2022 to bridge the Academic Innovator’s (AcIns) knowledge gap from idea to clinical implementation. Led by Northwestern University, anchored on CBC infrastructure that has developed diverse cohorts of PhD trained Entrepreneurial Fellows (EFs) and enabled translational awards across the three major Chicago universities, incorporating clinical translational expertise from a multi-campus network, and making such services available across nine Chicago research institutions, the Chicago Biomedical Consortium Hub for Innovative Technology and Entrepreneurship in the Sciences (CBC-HITES) will build a scaled multi-campus, academic service center for AcIns who want to develop biopharma small molecules, biologics, and new diagnostic/therapeutic modalities (e.g. cell and genetic therapies). The CBC-HITES will provide Chicago’s AcIns with multiple services, starting with the Request for Applications (RFA) stage and culminating in project execution. Under expert supervision by ex-industry personnel and a professional biopharmaceutical project manager, the center’s EFs will develop the AcIns’ ideas into industry grade analyses and project plans. Analyses are scientifically and clinically validated and, ultimately, validated by the end buyer, through an EF/AcIn joint presentation to a venture External Review Board (venture ERB) to inform funding. CBC – HITES’s leadership includes physician/surgeon scientists and expert drug hunters with connections to the city’s Clinical and Translational Science Awards (CTSA)s, community physician groups and healthcare organizations to better integrate clinical perspectives with deep discovery capabilities. The center also incorporates regulatory and implementation science into the hub. Projects funded by CBC-HITES will engage VC 1-2 years before equity financing is needed, and, depending on when they are screened out, unfunded projects receive a large body of research and a gap analysis that can be used for resubmission or alternative funding. VC are connected to promising AcIns and curated research, making their jobs easier. During their one to two years of training, EFs are networked to the universities, each other, and the broader ecosystem and then go to work in Chicago’s entrepreneurial ecosystem, pulling more academic assets out of the universities and thus maximizing the utility of their training. Intentionally recruiting diverse cohorts of EFs enables a strong, inclusive bioeconomy that can attract VC funding and more talent.

项目摘要 芝加哥都会大都会统计领域拥有三所R1大学和多个研究机构，因此 通过学术创新，但需要吸引更多的早期生物制药特定的资本和更多的“生物 - 企业家”经过培训，可以将基于大学的项目与知识和资金联系起来，以推出 生物医学在新兴生态系统中的应用。芝加哥生物医学财团（CBC）， 伊利诺伊大学芝加哥大学（UIC）之间的慈善资助研究联盟 芝加哥（UC）和西北大学（NU）成立于2006年，于2016年重新构想，并更新了 在2022年，弥合学术创新者（ACIN）的知识差距，从想法到临床实施。引领 西北大学（Northwestern University 企业家研究员（EFS），并在芝加哥三所主要大学中启用了翻译奖 从多校园网络中纳入临床翻译专业知识，并提供此类服务 在芝加哥九个芝加哥研究机构，芝加哥生物医学联盟创新枢纽 科学技术和企业家精神（CBC-Hites）将建立一个规模的多校园，学术 想要开发生物制药的小分子，生物制剂和新的ACIN服务中心 诊断/治疗方式（例如细胞和基因疗法）。 CBC-Hites将从申请请求开始，为芝加哥的Acins提供多种服务 （RFA）阶段和最终在项目执行中。在前行业人员的专家监督下 专业的生物制药项目经理，该中心的EFS将把Acins的想法发展为行业 等级分析和项目计划。分析是科学和临床验证的，最终由 最终买家，通过EF/ACIN联合介绍给风险外部审查委员会（Venture ERB） 告知资金。 CBC - HITE的领导包括身体/外科医生科学家和专家毒品猎人 与城市的临床和转化科学奖（CTSA）的联系，社区物理团体 和医疗组织，可以更好地将临床观点与深厚发现能力相结合。中心 还将监管和实施科学纳入枢纽。 由CBC-Hites资助的项目将在需要股权融资之前1 - 2年与VC互动，并取决于 当他们被筛选时，无资金的项目将获得大量的研究和差距分析 用于重新提交或替代资金。 VC与有前途的刺激素和精选研究相关， 使他们的工作更容易。在他们的一到两年的培训中，EFS与大学建立了联系 其他，更广泛的生态系统，然后在芝加哥的企业家生态系统中工作，吸引更多 学术资产是从大学中获得的，从而最大程度地提高了培训的实用性。故意招募 潜水员队列的EFS可以实现强大的包容性生物经济性，可以吸引风险投资和更多人才。