Core 3: Biostatistics, Data Management, and Bioinformatics

核心 3：生物统计学、数据管理和生物信息学

• 批准号: 10006810
• 负责人: Xuelin Huang
• 金额: $ 16.9万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-05 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006810
• 关键词: Address; Basic Science; Bioinformatics; Biometry; Cancer Center; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communication; Conduct Clinical Trials; Confidentiality of Patient Information; Consultations; Custom; Data; Data Analyses; Data Collection; Data Management Resources; Data Security; Databases; Development; Dimensions; Doctor of Medicine; Ensure; Experimental Designs; Formulation; Futility; Genomics; Human Resources; Laboratory Study; Methodology; Monitor; Multi-Institutional Clinical Trial; Patients; Process; Proteomics; Publications; Publishing; Quality Control; Reporting; Research; Research Design; Research Personnel; Resources; Safety; Statistical Data Interpretation; Statistical Models; Techniques; Texas; Translational Research; Universities; base; career; cost effective; data acquisition; data integration; data management; data quality; data resource; design; exome sequencing; experimental study; genomic data; high dimensionality; high throughput analysis; innovation; laboratory experiment; leukemia; meetings; models and simulation; preclinical study; programs; prospective; research study; sound; symposium; transcriptome sequencing; whole genome

Project Summary The major objective of the Biostatistics and Bioinformatics Core (Core 3) is to provide centralized biostatistics, bioinformatics, and database support for all Projects and Cores. Core 3 will provide guidance in the design and conduct of clinical trials and other experiments that arise from the ongoing research of the SPORE, facilitate prospective collection, entry, quality control, and integration of data for the basic science, pre-clinical, and clinical studies, and provide bioinformatics data analysis of high-throughput and high-dimensional genomics data. We will provide innovative and tailored statistical modeling, simulation techniques, and data analyses for the main projects, developmental research and career enhancement projects, and other cores to achieve their specific aims. We will conduct data analyses and prepare statistical reports for all experiments within all projects, ensure that the results of all projects are appropriately interpreted, and assist all project investigators in the publication of scientific results. Core 3 will also be a resource for intra- and inter-SPORE collaborations, including study design and developing databases for multi-center clinical trials.

项目概要 生物统计学和生物信息学核心（核心 3）的主要目标是提供集中的生物统计学、 生物信息学以及所有项目和核心的数据库支持。核心 3 将提供设计和 进行 SPORE 正在进行的研究中产生的临床试验和其他实验，促进 基础科学、临床前和临床前数据的前瞻性收集、输入、质量控制和整合 临床研究，并提供高通量、高维基因组学的生物信息学数据分析 数据。我们将为以下领域提供创新和定制的统计建模、模拟技术和数据分析： 主要项目、发展研究和职业提升项目以及其他核心项目，以实现其目标 具体目标。我们将对所有实验进行数据分析并准备统计报告 项目，确保所有项目的结果得到适当解释，并协助所有项目调查员 在科学成果的发表方面。 Core 3 还将成为 SPORE 内部和 SPORE 之间协作的资源， 包括研究设计和开发多中心临床试验数据库。