Biocompatible Optics

生物相容性光学器件

• 批准号: 8176892
• 负责人: Seok-Hyun Andy Yun
• 金额: $ 26.2万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-02 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8176892
• 关键词: Address; Adoption; Adverse effects; Animals; Biocompatible; Biocompatible Materials; Biopolymers; Catheters; Characteristics; Cicatrix; Clinical; Devices; Diagnosis; Diagnostic; Endoscopes; Excision; Fiber; Fiber Optics; Foreign Bodies; Glass; Goals; Histology; Implant; Inflammation; Lead; Life; Light; Lighting; Mechanics; Methods; Modeling; Monitor; Mus; Operative Surgical Procedures; Optics; Penetration; Performance; Photochemotherapy; Phototherapy; Plastics; Process; Research; Safety; Side; Skin; Source; Speed; Surface; Techniques; Therapeutic; Time; Tissues; Translations; Trauma; Wound Healing; base; bench to bedside; biocompatible polymer; biomaterial compatibility; bioresorption; crosslink; design; flexibility; implanted sensor; in vivo; insight; novel strategies; optical fiber; repaired; research study; response; success; two-dimensional; wound

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a new class of biocompatible optical devices for light- based therapy, surgery and diagnosis. A variety of optical techniques, such as photochemical tissue bonding and photodynamic therapy, require efficient delivery of light deep into tissues, but the limited penetration of light in tissue constitutes a serious constraint in clinical use. Fiber-optic devices or catheters have been useful in bringing a light source close to the target tissue in the body. However, delivering the light further into the tissue has remained a challenge. In this project, a new approach based on bio-absorbable and implantable light-delivery devices is proposed. This contrasts with conventional optical fibers made of glass or plastic that are not biocompatible and, thus, must be removed from the body soon after use. Using biocompatible polymers, we will develop thin flexible waveguides and use them in a photochemical tissue bonding (PTB) application. The fabricated biodegradable devices can be inserted between the interfaces of tissue to be bonded and induce photochemical bonding in regions into which light can otherwise not penetrate. The devices will be eventually resorbed thus eliminating the need for removal that would most likely damage the tissue bond. The safety and efficacy of this approach will be evaluated in ex-vivo models of skin wound closure and in-vivo animal studies of biocompatibility. While the initial focus of the project is on light delivering devices for PTB, a variety of other bioabsorbable and implantable optical functional devices are envisioned and can make a far-reaching impact in light-based therapy, surgery, and diagnosis. The project is therefore expected to have high impact and might well herald a new paradigm in photomedicine. PUBLIC HEALTH RELEVANCE: Biocompatible and biodegradable optical devices will accelerate and expand the clinical adoption of a variety of light-based therapeutics, surgical approaches and diagnostics. In-dwelling biocompatible and biodegradable optical networks can be used for performing surgical repair, monitoring tissue status following trauma or surgery and to deliver light therapies for accelerated wound healing.

描述（由申请人提供）：该项目的长期目标是开发一类新的生物相容性光学设备，用于基于光的治疗，手术和诊断。各种光化技术，例如光化学组织键合和光动力疗法，都需要有效地将光线递送到组织中，但是在组织中光的渗透有限构成了临床用途的严重限制。光纤设备或导管对将光源接近体内的靶组织非常有用。但是，将光进一步输送到组织中仍然是一个挑战。在这个项目中，提出了一种基于生物吸收和可植入的轻型设备的新方法。这与不可生物相容性的玻璃或塑料制成的常规光纤形成鲜明对比，因此必须在使用后尽快从体内移除。使用生物相容性聚合物，我们将开发薄柔性波导，并将其用于光化学组织键合（PTB）。可以在键合的组织界面之间插入制造的可生物降解装置，并在光线无法穿透的区域中诱导光化学键合。这些设备最终将被吸收，从而消除了去除的需求，这很可能会损害组织键。这种方法的安全性和有效性将在皮肤伤口闭合和体内动物生物相容性研究的前体内进行评估。虽然该项目的最初重点是为PTB提供照明设备，但设想了许多其他可吸收和可植入的光学功能设备，并可能对基于光的治疗，手术和诊断产生深远的影响。因此，该项目有望具有很高的影响力，并且很可能会预示摄影医学中的新范式。 公共卫生相关性：生物相容性和可生物降解的光学设备将加速和扩展临床采用各种基于光的疗法，外科手术方法和诊断。室内生物相容性和可生物降解的光网络可用于进行手术修复，受伤或手术后的组织状态，并提供轻疗法，以加速伤口愈合。