2011 Cartilage Biology & Pathology GRC

2011年软骨生物学

• 批准号: 8119807
• 负责人: Karen M. Lyons
• 金额: $ 2.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119807
• 关键词: Academia; Address; Adult; Aging; Biochemistry; Biology; Biomechanics; Birth; Bone Marrow; Bone Tissue; Cartilage; Cartilage Diseases; Cellular biology; Cessation of life; Chemicals; Childhood; Clinic; Clinical; Collaborations; Complex; Data; Degenerative Disorder; Degenerative polyarthritis; Development; Developmental Biology; Diagnosis; Discipline; Disease; Engineering; Environmental Risk Factor; Europe; Event; Extracellular Matrix; Fostering; Friction; Future; Genes; Genetic; Goals; Government; Growth; In Vitro; Industry; Interdisciplinary Study; Intervertebral disc structure; Investigation; Joints; Knowledge; Life; Maintenance; Mediating; Mentors; Modeling; Molecular Biology; Natural regeneration; Occupational; Orthopedics; Pain; Participant; Pathology; Population; Postdoctoral Fellow; Prevalence; Prevention; Public Health; Replacement Arthroplasty; Research; Research Personnel; Rheumatoid Arthritis; Risk; Scientist; Senior Scientist; Series; Shock; Signal Pathway; Site; Skeleton; Source; Stem cells; Surface; Time; Tissue Engineering; Tissues; Vertebral column; arthropathies; bone; cellular engineering; congenital skeletal disorder; effective therapy; graduate student; improved; in vivo; insight; interdisciplinary collaboration; interest; intervertebral disk degeneration; meetings; novel; planetary Atmosphere; posters; programs; repaired; success; symposium; synthetic biology; treatment strategy; vertebra body

DESCRIPTION (provided by applicant): This is a request for support for the fifth meeting in a highly successful series of Gordon Research Conferences on Cartilage Biology and Pathology, to be held at the Ventura Beach Marriott, Ventura Beach, Ca, March -11, 2011. Building on the success of the previous conferences, the meeting brings together outstanding senior and junior scientists, including advanced graduate students and postdoctoral fellows, for a 4.5 day program of formal presentations, poster sessions, and informal discussions. The participants share an interest in cartilage biology and pathology, but represent a broad range of disciplines, including developmental biology, extracellular matrix biochemistry, cell and molecular biology, tissue engineering, pathology, genetics, synthetic biology, and orthopaedics. When cartilage fails, the consequences can be severe, ranging from death near the time of birth to reduced growth of the skeleton during childhood, or degenerative joint and intervertebral disc disease in adults. The prevalence of adult diseases of cartilage is increasing in the aging US population. Great strides have been made in the identification of genes that control cartilage formation, and loci that predispose to degenerative disease. At the same time, stem cell and tissue engineering studies are increasing the potential options for repair and regeneration of damaged cartilage. However, much remains to be understood before this knowledge can be employed in the clinic. This meeting will address where we stand today with respect to therapy for cartilage, and what developments are in the pipeline. This is the ONLY meeting that brings together researchers spanning the broad spectrum of cartilage biology in an informal setting where it is possible to interact extensively. The conference is held every other year, alternating between a site in Europe and a site in the US, maximizing opportunities for interactions with colleagues around the world. The meeting is distinctive in its ability to provide junior scientists, postdoctoral fellows, and advanced graduate students extensive access to senior scientists, enabling mentoring, networking, and establishment of collaborations. The conference has consistently been rated as "outstanding" by the participants. The format remains unchanged from our previous highly successful conferences, with ample time for informal discussions.

描述（由申请人提供）：这是在一系列高度成功的戈登（Gordon）研究会议上进行第五次会议的请求海报会议和非正式讨论。参与者对软骨生物学和病理学有兴趣，但代表了广泛的学科，包括发育生物学，细胞外基质生化，细胞和分子生物学，组织工程，病理学，遗传学，合成生物学和矫形器。当软骨失败时，后果可能会很严重，从诞生时代的死亡到童年时期骨骼的生长降低，或成人的退化性关节和椎间盘疾病。在美国老年人群中，软骨的成人疾病的患病率正在增加。在控制软骨形成的基因和易于退化性疾病的基因座的基因方面取得了长足的进步。同时，干细胞和组织工程研究正在增加修复和再生软骨的潜在选择。但是，在诊所使用这些知识之前，还有很多待了解。这次会议将解决我们今天在软骨治疗方面的立场，以及在管道中的发展。这是唯一将跨越各种软骨生物学的研究人员聚集在非正式环境中的研究人员，可以进行广泛的相互作用。该会议每隔一年举行一次，在欧洲的一个地点和美国的一个地点之间交替，从而最大程度地与世界各地的同事进行互动的机会。这次会议在提供初级科学家，博士后研究员以及高级研究生的能力方面与高级科学家提供了广泛的访问，从而实现了指导，网络和合作的建立。会议一直被参与者评为“杰出”。与以前的非常成功的会议相比，该格式保持不变，并有足够的时间进行非正式讨论。