Neuroscience, Immunology, Social Adversity and the Roots of Addictive Behaviors: Toward a New Framework for Drug Use Etiology and Prevention

神经科学、免疫学、社会逆境和成瘾行为的根源：建立药物使用病因学和预防的新框架

• 批准号: 10023720
• 负责人: Gene H. Brody
• 金额: $ 178.14万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10023720
• 关键词: Addictive Behavior; Adolescence; Affect; African American; Behavior; Behavioral; Biological; Buffers; Centers of Research Excellence; Childhood; Chronic; Chronic stress; Communities; Consultations; Consumption; Data; Development; Discipline; Drug abuse; Drug usage; Eating; Economics; Emotions; Etiology; Exposure to; Family; Fatty acid glycerol esters; Food; Fostering; Funding; Generations; Immune; Immunology; Inflammation; Infrastructure; Intervention; Investigation; Low income; Mentors; Modeling; National Institute of Drug Abuse; Neurobiology; Neurocognitive; Neuroimmune; Neuroimmunomodulation; Neurosciences; Participant; Peripheral; Physiological; Pilot Projects; Plant Roots; Population; Poverty; Prevention; Prevention program; Preventive; Process; Provider; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Science; Scientist; Skin; Specific qualifier value; Stress; System; Testing; Training; Transact; Underrepresented Groups; United States National Institutes of Health; Work; Youth; cardiometabolic risk; career; caregiving; connective tissue-activating peptide; contextual factors; design; drug abuse prevention; drug use vulnerability; emotion regulation; ethnic minority population; evidence base; experience; health disparity; image processing; imaging facilities; innovation; member; minority communities; multilevel analysis; network models; neural circuit; next generation; prevention evaluation; programs; ranpirnase; resilience; social; sugar; supportive environment; theories; tool

PROJECT SUMMARY: Overall Center The Center for Translational and Prevention Science (CTAPS; P20 MH068666, P30 DA027827) has been funded continuously since 2003 to advance next-generation basic and preventive investigations of risk, resilience, and drug use among African American young people living in resource poor communities in the southeastern US. CTAPS has pioneered research demonstrating how exposures to economic and social adversity promote drug use through their effects on neurobiological and peripheral systems. Of particular importance, research sponsored by CTAPS also has demonstrated the promise of family-centered drug use prevention programming in shielding young people from these neurobiological risks. At present, transformative progress in the prevention of addictive behavior among populations exposed to chronic stress has been hampered significantly by the lack of (a) integrative theoretical frameworks that generate hypotheses regarding the risk and resilience mechanisms that connect social adversity to addictive behavior and cardiometabolic risk, (b) infrastructures that can collect model driven data on multiple neurocognitive, peripheral biological, and behavioral systems associated with chronic stress, and (c) transdisciplinary teams that can integrate these data into the design and evaluation of prevention programs. The theoretical framework of the proposed P50 Research Center of Excellence is a next generation, neuroimmune network (NIN) model that CTAPS scientists developed to better describe the ways in which exposure to social adversity predispose young people to the onset and escalation of diverse forms of addictive behaviors. The NIN model specifies stress-induced alterations in the transactions between peripheral inflammation and neurocognitive systems that subserve emotion regulation in the development of addictive behavior vulnerability. As a P50 Center, we propose to build on and expand CTAPS’ pioneering work on (a) the biological and neurocognitive contributors to addictive behaviors that drive many drug use and health disparities African Americans’ experience and (b) the potential of family-centered prevention programming to ameliorate the influence of growing up in chronically stressful contexts. We will leverage an established team of investigators from diverse disciplines and an established infrastructure for testing transdisciplinary hypotheses. This infrastructure includes efficient, established pipelines connecting P50 research project (RP) and pilot study investigators to intellectual resources, wet labs, a state-of-the-science imaging facility, and a world class platform for processing imaging data. We will implement three innovative, thematically integrated RPs. RPs, innovative pilot projects, an expanded national resource system, and investigator development activities will be supported through our infrastructure system composed of a Research Support Core, an Administrative Core, and a Pilot Core. CTAPS activities will have wide-reaching implications for research, practice, and prevention concerning drug use and cardiometabolic risk in low-income and ethnic minority communities. 1

项目概要：整体中心 转化与预防科学中心（CTAPS；P20 MH068666，P30 DA027827） 自2003年以来持续资助，以推进下一代风险的基础和预防性调查， 生活在资源匮乏社区的非裔美国年轻人的复原力和吸毒情况 美国东南部地区的 CTAPS 率先开展了研究，展示了经济和社会的风险敞口。 逆境通过影响神经生物学和外周系统来促进药物的使用。 重要性，CTAPS 赞助的研究也证明了以家庭为中心的药物使用的前景 目前，预防规划旨在保护年轻人免受这些神经生物学风险。 在预防长期承受压力的人群中成瘾行为方面取得的进展 由于严重缺乏 (a) 综合理论框架而受到阻碍，这些理论框架产生了以下方面的假设： 将社会逆境与成瘾行为和心脏代谢风险联系起来的风险和恢复机制， (b) 可以收集有关多种神经认知、外周生物和神经元的模型驱动数据的基础设施 与慢性压力相关的行为系统，以及（c）可以整合这些数据的跨学科团队 纳入预防计划的设计和评估。 卓越研究中心是 CTAPS 科学家开发的下一代神经免疫网络 (NIN) 模型 旨在更好地描述暴露在社会逆境中的年轻人如何容易陷入困境 NIN 模型指出了各种形式的成瘾行为的发生和升级。 周围炎症和神经认知系统之间的相互作用发生改变，从而促进 成瘾行为脆弱性发展中的情绪调节 作为 P50 中心，我们建议建立。 继续并扩展 CTAPS 在以下方面的开创性工作：(a) 成瘾的生物和神经认知因素 导致许多吸毒和健康差异的行为 非裔美国人的经历和 (b) 潜力 以家庭为中心的预防规划，以减轻在长期压力下成长的影响 我们将利用来自不同学科的成熟研究团队和成熟的研究团队。 用于测试跨学科假设的基础设施 该基础设施包括高效的、既定的。 将 P50 研究项目 (RP) 和试点研究研究者与智力资源、湿实验室、 我们将拥有最先进的成像设施和世界一流的成像数据处理平台。 实施三个创新的、主题综合的移民计划、创新试点项目、扩大的国家计划。 资源系统和研究者发展活动将通过我们的基础设施系统得到支持 由研究支持核心、行政核心和 CTAPS 活动组成。 对药物使用和心脏代谢风险的研究、实践和预防产生广泛影响 在低收入和少数民族社区。 1