Non-contact, THz Sensing of Corneal Hydration

非接触式太赫兹角膜水合感测

• 批准号: 8088276
• 负责人: WARREN S GRUNDFEST
• 金额: $ 43.16万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8088276
• 关键词: Ablation; Animals; Calibration; Characteristics; Cornea; Corneal Diseases; Data; Diagnosis; Disease; Ensure; Eye; Fuchs' Endothelial Dystrophy; Goals; Histology; Human; Hydration status; Image; Imaging Device; Institutional Review Boards; Laser In Situ Keratomileusis; Lighting; Maps; Measurement; Measures; Methods; Modeling; Monitor; Operative Surgical Procedures; Oryctolagus cuniculus; Patients; Photons; Proteomics; Radiation; Resolution; Safety; Simulate; Spectrum Analysis; System; Techniques; Technology; Testing; Thick; Ultrasonography; Water; eye center; imaging modality; improved; in vivo; mathematical model; new technology; operation; phantom model; simulation; tool development; volunteer

DESCRIPTION (provided by applicant): The goal of this proposal is to develop a THz imaging system to image and spatially map the hydration of the cornea. Corneal hydration is currently measured using ultrasound pachymetry and is derived from an empiric relationship between central corneal thickness and available hydration data. This proposal will use corneal spectroscopy and reflectance data to improve models of THz reflectivity from the cornea. These models will be evaluated using phantoms and in-vivo rabbit corneas. Preliminary data suggest that THz imaging can measure corneal hydration with 0.1% accuracy and a spatial resolution of 600 um. The simulations and phantom models, and animal studies will be used to evaluate the feasibility of the approach and verify the ability of corneal THz imaging to discern hydration changes characteristic of corneal diseases. One of the advantages of THz radiation is its extremely low photon energy. It is eye safe and operates at 10 - 20 uW. To ensure safety for human use we will evaluate THz illumination on the cornea of rabbits at 50 5W and examine the corneas with histology and proteomic analysis. Once we have confirmed safety and obtained necessary IRB approvals we will conduct initial human corneal imaging trials in normal volunteers. After obtaining baseline information from normal patients (N = 60) we will proceed to study hydration in patients before and after DSEK surgery (N = 20), and before and after LASIK surgery (N = 20). Data accumulated from these studies will be analyzed to assess the feasibility of THz imaging to monitor hydration levels as a function of disease state. 1 PUBLIC HEALTH RELEVANCE: This project will develop a new imaging tool for non-contact, high resolution measurements of corneal hydration. This technology, THz imaging, is a low energy, safe imaging modality that has significant potential advantages over current measurement systems. This proposal develops the mathematical models, animal studies, and preliminary human feasibility testing to evaluate the potential of this new technology to detect, diagnose, and track hydration changes in the cornea as a function of disease. 2

描述（由申请人提供）：该提案的目标是开发太赫兹成像系统，对角膜的水合作用进行成像和空间映射。目前，角膜水合作用超声测厚法进行测量，并源自中央角膜厚度和可用水合作用数据之间的经验关系。该提案将使用角膜光谱和反射率数据来改进角膜太赫兹反射率的模型。这些模型将使用体模和体内兔角膜进行评估。初步数据表明，太赫兹成像可以以 0.1% 的精度和 600 微米的空间分辨率测量角膜水合。模拟和体模模型以及动物研究将用于评估该方法的可行性，并验证角膜太赫兹成像辨别角膜疾病特征的水合变化的能力。太赫兹辐射的优点之一是其光子能量极低。它对眼睛安全，工作功率为 10 - 20 uW。为了确保人类使用的安全，我们将评估 50 5W 的太赫兹照明对兔子角膜的影响，并通过组织学和蛋白质组分析检查角膜。一旦我们确认安全性并获得必要的 IRB 批准，我们将在正常志愿者中进行初步的人类角膜成像试验。在获得正常患者 (N = 60) 的基线信息后，我们将继续研究 DSEK 手术前后 (N = 20) 以及 LASIK 手术前后 (N = 20) 患者的水合作用。将分析这些研究积累的数据，以评估太赫兹成像监测水合水平作为疾病状态函数的可行性。 1 公共健康相关性：该项目将开发一种新的成像工具，用于非接触式、高分辨率测量角膜水合。这项太赫兹成像技术是一种低能量、安全的成像方式，与当前的测量系统相比具有显着的潜在优势。该提案开发了数学模型、动物研究和初步人体可行性测试，以评估这项新技术检测、诊断和跟踪角膜水合变化随疾病变化的潜力。 2