Stress, Anxiety, and Paternal Behavior in Fathers

父亲的压力、焦虑和父亲行为

基本信息

批准号：
8076323
负责人：
WENDY SALTZMAN
金额：
$ 22.57万
依托单位：
UNIVERSITY OF CALIFORNIA RIVERSIDE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-24 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8076323
关键词：
Acute Address Affect Animal Model Anxiety Attention Aversive Stimulus Behavior Behavioral Biological Factors Biological Models Biology Birth Brain Buffers California Caring Child Child Abuse and Neglect Child Care Chronic Chronic stress Cognitive Development Emotional Endocrine Event Exhibits Fathers Female Foundations Future Hormonal Hormonal Change Hormones Human Infant Care Investigation Lactation Lead Maintenance Mammals Maternal Behavior Modeling Mothers Mus Neuropeptides Neurosecretory Systems Oxytocin Parenting behavior Paternal Behavior Peptides Peromyscus Physiological Play Pregnancy Prevention Prolactin Psychopathology Psychosocial Factor Regulation Reproduction Research Rodent Role Signal Transduction Stress System Testing Time Unemployment Vasopressins Woman Work abuse neglect acute stress base biological adaptation to stress child physical abuse fatherhood insight male maltreatment men neonate novel offspring physical neglect prevent psychosocial public health relevance relating to nervous system response stressor

项目摘要

DESCRIPTION (provided by applicant): Human fathers in many cultures provide a significant amount of child care and play important roles in the cognitive, emotional, and psychosocial development of their children. At the same time, fathers and father surrogates perpetrate a disproportionately large number of instances of severe physical child abuse and child neglect, often in association with high levels of stress or stress-related psychopathology. The factors contributing to child maltreatment by fathers have received surprisingly little attention; however, stress, associated with such factors as unemployment, financial hardship, and parenting difficulties, is thought to play a role. In mammalian mothers, including women, hormonal and neural changes associated with pregnancy, parturition, and lactation lead to reductions in stress-responsiveness, anxiety, and fearfulness, changes that are thought to facilitate the onset of maternal behavior and to buffer maternal care from inhibition by stress or anxiety. It is unknown whether fathers in biparental species undergo similar changes in stress-responsiveness and emotionality. The onset of paternal care in these species, however, is associated with altered activity of several hormone and neuropeptide systems that have been implicated in the regulation of the stress response and emotionality. We suggest, therefore, that these neuroendocrine changes may function to reduce anxiety, fearfulness, and stress-responsiveness in new fathers, thereby facilitating the onset and maintenance of paternal behavior and reducing the likelihood that paternal care will be inhibited under stressful or anxiogenic conditions. In the proposed research, we aim to identify both the effects of stress on paternal care and the effects of fatherhood on stress-responsiveness in a biparental rodent, the California mouse. Specifically, we propose to determine (1) whether paternal care is inhibited by acute and/or chronic stress, and (2) whether fatherhood alters behavioral, hormonal, and neural responses to acute and chronic stressors. These studies will provide unique insights into mammalian paternal care and ultimately may have implications for preventing abuse and neglect of human children by fathers. PUBLIC HEALTH RELEVANCE: Many human fathers make important contributions to the care and development of their children; however, fathers and father surrogates are also responsible for a disproportionately large number of child physical abuse and neglect incidents, often under stressful or anxiogenic conditions. The proposed research will use a biparental rodent, the California mouse, as a model system to investigate how stress affects paternal care and, conversely, whether fatherhood influences males' behavioral, hormonal, and neural responses to stress. This research will substantially advance our understanding of the biology of paternal behavior in humans and other mammals, and may ultimately have implications for the prevention of child maltreatment by fathers.

描述（由申请人提供）：许多文化中的人类父亲提供了大量的儿童保育服务，并在孩子的认知、情感和社会心理发展中发挥着重要作用。与此同时，父亲和父亲代理人犯下大量严重虐待儿童和忽视儿童的事件，往往与高水平的压力或与压力相关的精神病理学有关。令人惊讶的是，导致父亲虐待儿童的因素却很少受到关注；然而，与失业、经济困难和养育子女困难等因素相关的压力被认为发挥了一定作用。在哺乳动物母亲中，包括女性，与怀孕、分娩和哺乳相关的荷尔蒙和神经变化会导致压力反应、焦虑和恐惧的减少，这些变化被认为会促进孕产妇行为的发生，并缓冲孕产妇护理的抑制由于压力或焦虑。目前尚不清楚双亲物种的父亲在压力反应和情绪方面是否会经历类似的变化。然而，这些物种中父亲照顾的开始与几种激素和神经肽系统的活性改变有关，这些激素和神经肽系统与压力反应和情绪的调节有关。因此，我们认为这些神经内分泌的变化可能有助于减少新父亲的焦虑、恐惧和压力反应，从而促进父亲行为的发生和维持，并减少父亲照顾在压力或焦虑条件下受到抑制的可能性。在拟议的研究中，我们的目标是确定压力对父亲照顾的影响以及父亲身份对双亲啮齿动物（加州小鼠）压力反应的影响。具体来说，我们建议确定（1）父亲的照顾是否受到急性和/或慢性压力的抑制，以及（2）父亲身份是否会改变对急性和慢性压力源的行为、激素和神经反应。这些研究将为哺乳动物的父亲照顾提供独特的见解，并最终可能对防止父亲虐待和忽视人类儿童产生影响。公共卫生相关性：许多人类父亲为孩子的照顾和发展做出了重要贡献；然而，父亲和父亲代理人也对大量儿童身体虐待和忽视事件负有责任，这些事件往往是在压力或焦虑的情况下发生的。拟议的研究将使用双亲啮齿动物（加州小鼠）作为模型系统，研究压力如何影响父亲的照顾，以及相反，父亲身份是否影响男性对压力的行为、激素和神经反应。这项研究将极大地增进我们对人类和其他哺乳动物父亲行为生物学的理解，并可能最终对预防父亲虐待儿童产生影响。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effect of reproductive status on hypothalamic-pituitary-adrenal (HPA) activity and reactivity in male California mice (Peromyscus californicus).

DOI：
10.1016/j.physbeh.2013.02.016
发表时间：
2013-03-15
期刊：
Physiology & behavior
影响因子：
2.9
作者：
Harris BN;Saltzman W
通讯作者：
Saltzman W

Plasticity of the paternal brain: Effects of fatherhood on neural structure and function.

DOI：
10.1002/dev.22097
发表时间：
2021-07
期刊：
Developmental psychobiology
影响因子：
2.2
作者：
Horrell ND;Acosta MC;Saltzman W
通讯作者：
Saltzman W

Paternal responsiveness is associated with, but not mediated by reduced neophobia in male California mice (Peromyscus californicus).

DOI：
10.1016/j.physbeh.2012.05.012
发表时间：
2012-08-20
期刊：
PHYSIOLOGY & BEHAVIOR
影响因子：
2.9
作者：
Chauke, Miyetani;de Jong, Trynke R.;Garland, Theodore, Jr.;Saltzman, Wendy
通讯作者：
Saltzman, Wendy

Differences in placentophagia in relation to reproductive status in the California mouse (Peromyscus californicus).

加州小鼠（Peromyscus californicus）的胎盘吞噬差异与生殖状态的关系。

DOI：
10.1002/dev.21154
发表时间：
2014
期刊：
Developmental psychobiology
影响因子：
2.2
作者：
Perea-Rodriguez,JuanP;Saltzman,Wendy
通讯作者：
Saltzman,Wendy

Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation.

DOI：
10.1093/icb/icx047
发表时间：
2017-09
期刊：
Integrative and comparative biology
影响因子：
2.6
作者：
W. Saltzman;B. Harris;T. D. de Jong;J. P. Perea-Rodríguez;Nathan D. Horrell;Meng Zhao;J. R. Andrew
通讯作者：
W. Saltzman;B. Harris;T. D. de Jong;J. P. Perea-Rodríguez;Nathan D. Horrell;Meng Zhao;J. R. Andrew