ROLE OF CORTICOTROPIN-RELEASING FACTOR IN PRIMATE MATERNAL BEHAVIOR

促肾上腺皮质激素释放因子在灵长类动物母体行为中的作用

• 批准号: 8173089
• 负责人: WENDY SALTZMAN
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173089
• 关键词: Acute; Adrenal Glands; Affect; Animals; Biological Assay; Brain; Breeding; Callithrix; Callithrix jacchus jacchus; Chronic; Computer Retrieval of Information on Scientific Projects Database; Corticotropin; Corticotropin-Releasing Hormone; Endocrine; Female; Funding; Grant; Human; Hydrocortisone; Hypothalamic structure; Institution; Mammals; Maternal Behavior; Monkeys; Mothers; Neuropeptides; Neurosecretory Systems; Pituitary Gland; Primates; Printing; Psychoneuroendocrinology; Publications; Research; Research Personnel; Resources; Role; Series; Services; Source; Stress; United States National Institutes of Health; experience; relating to nervous system; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To characterize the effect of corticotropin-releasing factor in stress-related disruption of primate maternal behavior. Stress can inhibit maternal behavior in humans and other mammals; however, this effect is poorly understood, and the neural and neuroendocrine mechanisms are unknown. To begin to elucidate the mechanisms by which stress can alter maternal behavior in primates, we are conducting a series of experiments investigating the interactions between maternal behavior and stress in marmoset monkeys. Initial results indicate that lactating females may show altered neuroendocrine responses to stress as compared to non-breeding females, including somewhat dampened pituitary secretion of adrenocorticotropic hormone (ACTH) but elevated adrenocortical release of cortisol, resulting in a significantly altered cortisol:ACTH ratio. Second, we have found that neither acute nor chronic treatment with exogenous cortisol markedly affects maternal behavior in experienced mothers, under either baseline or stressful conditions. In contrast, initial findings from an ongoing experiment suggest that direct administration of the neuropeptide corticotropin-releasing factor (CRF) into the brain inhibits maternal responsiveness in lactating females. These results, although preliminary, suggest that stress may disrupt maternal behavior primarily through direct neural effects of CRF rather than through activation of the hypothalamic-pituitary-adrenal endocrine axis. This research used Animal Services and Assay Services. PUBLICATION: Saltzman W, Abbott DH. Effects of elevated circulating cortisol concentrations on maternal behavior in common marmoset monkeys (Callithrix jacchus). Psychoneuroendocrinology. 2009 Apr 10. [Epub ahead of print ] PMID: 19362777

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：表征促肾上腺皮质激素释放因子在压力相关的灵长类母性行为破坏中的作用。 压力会抑制人类和其他哺乳动物的母性行为；然而，人们对这种效应知之甚少，神经和神经内分泌机制尚不清楚。 为了开始阐明压力改变灵长类动物母性行为的机制，我们正在进行一系列实验，研究狨猴中母性行为与压力之间的相互作用。初步结果表明，与非繁殖雌性相比，哺乳期雌性可能表现出对压力的神经内分泌反应改变，包括垂体促肾上腺皮质激素（ACTH）分泌有所减弱，但肾上腺皮质释放皮质醇增加，导致皮质醇：ACTH比率显着改变。其次，我们发现，无论是在基线条件还是压力条件下，外源性皮质醇的急性或慢性治疗都不会显着影响有经验的母亲的母亲行为。 相比之下，一项正在进行的实验的初步结果表明，直接将神经肽促肾上腺皮质激素释放因子（CRF）注射到大脑中会抑制哺乳期雌性的母体反应。 这些结果虽然是初步的，但表明压力可能主要通过 CRF 的直接神经效应而不是通过激活下丘脑-垂体-肾上腺内分泌轴来扰乱母亲的行为。 这项研究使用了动物服务和化验服务。 发布： 萨尔兹曼 W，雅培 DH。循环皮质醇浓度升高对普通狨猴（Callithrix jacchus）母性行为的影响。精神神经内分泌学。 2009 年 4 月 10 日。[印刷前的电子版] PMID：19362777