Colorado Mycobacteria Conference: Focus on NTM

科罗拉多分枝杆菌会议：聚焦 NTM

基本信息

批准号：
10001954
负责人：
DEAN C CRICK
金额：
$ 1.2万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10001954
关键词：
Antibiotic Resistance Area Atmosphere Bacteria Biology Bronchiectasis Chronic Obstructive Airway Disease Collaborations Colorado Communities Complex Cystic Fibrosis Development Diagnostic Disease Domestic Animals Ecology Epidemiology Etiology Event Fostering Genus Mycobacterium Goals Health Immune response Immunology Incidence Individual Infection Infection Control International Lead Lung Lung diseases Lung infections Maps Mycobacterium Infections Mycobacterium abscessus Mycobacterium avium Complex Mycobacterium tuberculosis National Institute of Allergy and Infectious Disease Oral Organism Outcome Participant Pathology Population Prevalence Public Health Publishing Reporting Research Research Personnel Resistance Resources Risk Scientist Senior Scientist Skin Tissue Social Interaction Soft Tissue Infections Soil Source Therapeutic Training Translational Research Tuberculosis United States Update Vaccines Virulence Water Wild Animals antimicrobial base career career networking cystic fibrosis patients disorder prevention genome sequencing innovation interdisciplinary approach interest member next generation non-tuberculosis mycobacteria posters social soft tissue symposium tool treatment strategy whole genome

项目摘要

Abstract Non-tuberculous mycobacteria (NTM) comprise a large, diverse group of bacteria usually found in soil, water and wild and domestic animal populations. NTM were not recognized as significant sources of pulmonary disease until relatively recently. Unlike Mycobacterium tuberculosis, NTM do not cause tuberculosis (TB), but can cause skin and soft tissue infections, disseminated infections and severe lung disease, and pose a particular threat for those afflicted with cystic fibrosis, chronic obstructive pulmonary disease (COPD) or pre-existing bronchiectasis. There is currently no vaccine to protect from NTM infections. NTM are also intrinsically resistant to most existing antimicrobials. Among new antimicrobials currently under various stages of development, including those to treat TB, few have potent anti-NTM activity. Multiple studies indicate that the prevalence of NTM disease is increasing globally. The incidence and prevalence of NTM lung disease (NTM-LD) in the U.S. is also increasing, and now surpasses that of TB. However, we have a fundamentally poor understanding of NTM and the diseases they cause. The goals of the Colorado Mycobacteria Conference: Focus on NTM are to help fill the existing gaps in basic and translational NTM research by bringing together junior and senior scientists, clinicians and public health officials that do not often attend the same conferences, highlighting new findings, discussing lessons learned and, importantly, training the next generations of researchers and clinicians.

抽象的非结核分枝杆菌 (NTM) 包含一大类多样化的细菌，通常存在于土壤中，水以及野生和家畜种群。 NTM 未被视为重要来源直到最近才出现肺部疾病。与结核分枝杆菌不同，NTM 不会引起结核病 (TB)，但可引起皮肤和软组织感染、播散性感染和严重的肺部感染疾病，并对患有囊性纤维化、慢性阻塞性肺病的人构成特别威胁疾病（慢性阻塞性肺病）或已有的支气管扩张症。目前没有疫苗可以预防 NTM 感染。 NTM 本身对大多数现有抗菌药物也具有耐药性。目前正在研发的新型抗菌药物中在不同的发展阶段，包括治疗结核病的阶段，很少有具有有效的抗 NTM 活性的药物。多项研究表明 NTM 疾病的患病率在全球范围内正在增加。 NTM 肺的发病率和患病率美国的 NTM-LD 疾病也在增加，目前已超过结核病。然而，我们有一个从根本上来说，人们对 NTM 及其引起的疾病缺乏了解。科罗拉多队的目标分枝杆菌会议：关注NTM将有助于填补基础和转化NTM方面的现有空白通过将初级和高级科学家、临床医生和公共卫生官员聚集在一起进行研究，这些官员通常不参加同样的会议，强调新发现，讨论经验教训，重要的是，培训下一代研究人员和临床医生。