PHASE I STUDY OF ABSOLUTE ORAL BIOAVAILABILITY OF 5-FLUOROURACIL SOLUTION

5-氟尿嘧啶溶液绝对口服生物利用度的 I 期研究

• 批准号: 2349337
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2349337
• 关键词: antineoplastics; clinical research; clinical trial phase I; combination chemotherapy; drug administration rate /duration; drug interactions; drug screening /evaluation; fluorouracil; human subject; human therapy evaluation; neoplasm /cancer chemotherapy; oral administration; pharmacokinetics

This study was to determine the pharmacokinetics and absolute oral bioavailability of a 5-FU solution when administered in combination with oral 776C85, to evaluate the safety of the combination of oral 5-FU and 776C85, to evaluate the effects of multiple daily dosing on the pharmacokinetics of oral 5-FU solution when administered in combination with oral 776C85 and to collect preliminary information regarding the antitumor effect of the combination of oral 5-FU and 776C85. The study has been completed.

这项研究是为了确定药代动力学和绝对口服 与5-FU溶液的生物利用度结合使用 口服776C85，以评估口服5-FU和 776C85，以评估多种每日剂量对 组合给药时口服5-FU溶液的药代动力学 使用口服776C85，并收集有关 口服5-FU和776C85组合的抗肿瘤作用。 研究 已经完成。