SEARCH for Diabetes in Youth 3: Washington Site, Part B

搜索青少年糖尿病 3：华盛顿网站，B 部分

• 批准号: 8062983
• 负责人: Catherine Pihoker
• 金额: $ 68.74万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8062983
• 关键词: SEARCH; Diabetes; Youth; Washington; Site

DESCRIPTION (provided by applicant): SEARCH for Diabetes in Youth (SEARCH) is an on-going, multi-center study containing the largest and most ethnically diverse population of youth with diabetes ever studied in the US. In response to RFA-DP10-001, Component B, the SEARCH Cohort Study will utilize this unique resource by continuing the study of selected SEARCH participants to address the following Aims: 1) assess the prevalence, incidence, and risk factors for selected markers of chronic microvascular (retinopathy, nephropathy, and autonomic neuropathy) and macrovascular complications (hypertension, arterial stiffness) of diabetes; 2) assess the incidence and risk factors for acute complications of diabetes including serious hypoglycemia and diabetic ketoacidosis ; 3) conduct surveillance of mortality; and 4) determine the degree to which barriers of care, quality of care, and transition to adult care impact diabetes-related health outcomes including quality of life. Overlaid across these Aims, we will focus on the impact of race/ethnicity and other sociocultural factors, and biochemical dimensions of diabetes type, on diabetes-related health outcomes. The SEARCH Cohort Study will conduct an in-person research study visit on SEARCH participants incident in 2002 or later, with duration of diabetes > 5 years and with baseline data completed (expected n=3699). During this study medical history, anthropometric, biochemical, physiologic, and survey data will be collected and analyzed. The Washington SEARCH site includes 5 Puget Sound counties (King, Kitsap, Pierce, Thurston, and Snohomish) surrounding Seattle and Tacoma. We have successfully registered over 3,700 participants, and we are the second largest SEARCH site in terms of total number of surveys and baseline visits completed. With a high response rate to follow-up visits, and the significant expertise of Washington investigators in diabetes and its complications, we are strongly positioned to meet the aims of this study. This study will exploit the size and ethnic diversity of the study population to identify differences in both processes of care and health outcomes by traditional, clinical diabetes type; by the major race/ethnic groups in the US; and by employing a novel approach to segregate traditional clinical diabetes types by pathophysiologic dimensions. Thus, the SEARCH cohort study has a high likelihood of making a significant impact on the clinical care of youth with diabetes from all the major ethnic groups in the US and on national public health policy.

描述（由申请人提供）：在青年中寻找糖尿病（搜索）是一项正在进行的，多中心的研究，其中包含美国有史以来最大，最多样化的糖尿病年轻人。为了响应RFA-DP10-001，组件B，搜索队列研究将通过继续研究选定的搜索参与者的研究来利用这一独特资源来解决以下目的：1）评估慢性微血管疾病，视网膜病，肾病，肾上腺病和自动疗法的慢性小血管的流行，发病率和危险因素（均为肾小管病）的危险因素，并促进了（近距离疾病），并置于疾病的强度（杂种）（杂种）（杂种）（杂种）（杂种），（杂种）（杂种） 糖尿病; 2）评估包括严重低血糖症和糖尿病性酮症酸中毒，包括严重低血糖症的急性并发症的发生率和危险因素； 3）进行死亡的监视； 4）确定护理障碍，护理质量和向成人护理的过渡影响与糖尿病有关的健康结果，包括生活质量。覆盖了这些目标，我们将重点关注种族/种族和其他社会文化因素的影响，以及糖尿病类型的生化维度，对与糖尿病相关的健康结果的影响。搜索队列研究将对2002年或更晚的搜索参与者进行面对面的研究访问，糖尿病持续时间> 5年，基线数据完成（预期n = 3699）。在这项研究中，将收集和分析病史，人体测量学，生化，生理和调查数据。华盛顿搜索网站包括西雅图和塔科马的5个Puget Sound县（King，Kitsap，Pierce，Thurston和Snohomish）。我们已经成功注册了3,700多名参与者，就调查总数和完成的基线访问而言，我们是第二大搜索站点。凭借对随访的较高应对率，以及华盛顿调查人员在糖尿病及其并发症中的重要专业知识，我们在这项研究的目标方面有很强的位置。这项研究将利用研究人群的规模和种族多样性，以确定传统的临床糖尿病类型的护理和健康结果过程的差异。由美国的主要种族/族裔群体；并采用一种新颖的方法来通过病理生理维度隔离传统的临床糖尿病类型。因此，搜索队列研究很有可能对美国所有主要种族和国家公共卫生政策的糖尿病青年的临床护理产生重大影响。