TYPE 1 DIABETES GENETICS CONSORTIUM

1 型糖尿病遗传学联盟

• 批准号: 7603538
• 负责人: Catherine Pihoker
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603538
• 关键词: Accounting; Affect; African American; Age; American; Asia; Australia; Blood specimen; Class; Clinical; Collection; Complex; Complications of Diabetes Mellitus; Computer Retrieval of Information on Scientific Projects Database; Data; Diabetes Mellitus; Diagnosis; Disease; Ethnic Origin; Europe; Family; Family member; Funding; Genes; Genetic; Genetic Polymorphism; Genetic Risk; Grant; Individual; Institution; Insulin-Dependent Diabetes Mellitus; Latin America; Low Prevalence; MHC Class I Genes; Mexican Americans; North America; Parents; Play; Population; Prevalence; Purpose; Questionnaires; Recruitment Activity; Research; Research Personnel; Resources; Risk; Role; Siblings; Source; Testing; Twin Studies; United States National Institutes of Health; base; clinical phenotype; design; diabetes mellitus genetics; diabetes risk; gene interaction; genetic resource; international center; proband; Accounting; Affect; African American; Age; American; Asia; Australia; Blood specimen; Class; Clinical; Collection; Complex; Complications of Diabetes Mellitus; Computer Retrieval of Information on Scientific Projects Database; Data; Diabetes Mellitus; Diagnosis; Disease; Ethnic Origin; Europe; Family; Family member; Funding; Genes; Genetic; Genetic Polymorphism; Genetic Risk; Grant; Individual; Institution; Insulin-Dependent Diabetes Mellitus; Latin America; Low Prevalence; MHC Class I Genes; Mexican Americans; North America; Parents; Play; Population; Prevalence; Purpose; Questionnaires; Recruitment Activity; Research; Research Personnel; Resources; Risk; Role; Siblings; Source; Testing; Twin Studies; United States National Institutes of Health; base; clinical phenotype; design; diabetes mellitus genetics; diabetes risk; gene interaction; genetic resource; international center; proband

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multi-center, international, organized effort designed to identify the genes that determine one's risk of developing diabetes. From family and twin studies, it is known that the genetic basis of type 1 diabetes is complex, including genes with large and small effect. It is established that HLA Anti class II and class I genes play a major role in determining diabetes risk. However, it is apparent that HLA accounts for only approximately 50% of the total genetic risk of type 1 diabetes. Over the past two decades, several other genes and gene polymorphisms have been identified that contribute to diabetes risk. However, it has been difficult to fully assess the magnitude of individual gene effects and gene interactions due to limited clinical and genetic resources. In this study, multiple family members will be recruited in an organized, consistent fashion. The study will take place in North America (at least 9 centers, including CHRMC / Seattle), Europe, Asia, Australia, and Latin America. Families will be recruited as affected sib pairs (ASP), meaning two or more siblings with type 1 diabetes. Parents of ASP and other, unaffected siblings will also be invited to participate in the study. Data will be collected on clinical phenotype (e.g. age at diagnosis, ethnicity, body habitus, diabetes complications) on all subjects with diabetes. HLA class I and II genes, and at least 4 additional promising genetic loci, will be examined in each family member, in the context of disease status. Data are collected as blood samples and questionnaires, for research purposes only. Recently recruitment has been expanded to low prevalence trio families (proband and both parents) in the North American Network. Trios will be collected only in those populations where the prevalence of type 1 diabetes is low - that is, in populations where families with two affected offspring are very rare. Therefore, the trio collections will focus on Mexican-American and African-Americans. The testing will be exactly the same as for ASP families.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这是一种多中心，国际组织的努力，旨在识别确定糖尿病风险的基因。 从家族和双胞胎研究中，众所周知，1型糖尿病的遗传基础很复杂，包括具有较大和小作用的基因。 可以确定HLA抗II类和I类基因在确定糖尿病风险中起着重要作用。 但是，显然，HLA仅占1型糖尿病总遗传风险的约50％。 在过去的二十年中，已经确定了其他几个基因和基因多态性，这会导致糖尿病风险。 但是，由于临床和遗传资源有限，很难充分评估单个基因效应和基因相互作用的大小。 在这项研究中，将以有组织的，一致的方式招募多个家庭成员。 该研究将在北美（包括CHRMC /西雅图），欧洲，亚洲，澳大利亚和拉丁美洲进行至少9个中心进行。 家庭将被招募为受影响的SIB对（ASP），这意味着两个或多个患有1型糖尿病的兄弟姐妹。 ASP和其他人的父母也将邀请未受影响的兄弟姐妹参加这项研究。 将收集有关所有患有糖尿病患者的临床表型（例如诊断，种族，身体习惯，糖尿病并发症的年龄）的数据。 在疾病状况的背景下，将在每个家庭成员中检查HLA I和II类基因，以及至少4个其他有希望的遗传基因座。 数据仅用于研究目的，作为血液样本和问卷收集。 最近，招聘已扩展到北美网络中的低流行三人家庭（概率和父母）。 只有在1型糖尿病患病率较低的人群中收集三重奏 - 也就是说，在两个患有两个受影响后代的家庭的人群中很少见。 因此，三人收藏将集中于墨西哥裔美国人和非裔美国人。 测试将与ASP家族完全相同。