SEARCH for Diabetes in Youth 3: Washington Site, Part B

搜索青少年糖尿病 3：华盛顿网站，B 部分

• 批准号: 8531694
• 负责人: Catherine Pihoker
• 金额: $ 61.54万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531694
• 关键词: SEARCH; Diabetes; Youth; Washington; Site

Project Summary SEARCH for Diabetes in Youth (SEARCH) is an on-going, multi-center study containing the largest and most ethnically diverse population of youth with diabetes ever studied in the US. In response to RFA-DP10-001, Component B, the SEARCH Cohort Study will utilize this unique resource by continuing the study of selected SEARCH participants to address the following Aims: 1) assess the prevalence, incidence, and risk factors for selected markers of chronic microvascular (retinopathy, nephropathy, and autonomic neuropathy) and macrovascular complications (hypertension, arterial stiffness) of diabetes; 2) assess the incidence and risk factors for acute complications of diabetes including serious hypoglycemia and diabetic ketoacidosis ; 3) conduct surveillance of mortality; and 4) determine the degree to which barriers of care, quality of care, and transition to adult care impact diabetes-related health outcomes including quality of life. Overlaid across these Aims, we will focus on the impact of race/ethnicity and other sociocultural factors, and biochemical dimensions of diabetes type, on diabetes-related health outcomes. The SEARCH Cohort Study will conduct an in-person research study visit on SEARCH participants incident in 2002 or later, with duration of diabetes > 5 years and with baseline data completed (expected n=3699). During this study medical history, anthropometric, biochemical, physiologic, and survey data will be collected and analyzed. The Washington SEARCH site includes 5 Puget Sound counties (King, Kitsap, Pierce, Thurston, and Snohomish) surrounding Seattle and Tacoma. We have successfully registered over 3,700 participants, and we are the second largest SEARCH site in terms of total number of surveys and baseline visits completed. With a high response rate to follow-up visits, and the significant expertise of Washington investigators in diabetes and its complications, we are strongly positioned to meet the aims of this study. This study will exploit the size and ethnic diversity of the study population to identify differences in both processes of care and health outcomes by traditional, clinical diabetes type; by the major race/ethnic groups in the US; and by employing a novel approach to segregate traditional clinical diabetes types by pathophysiologic dimensions. Thus, the SEARCH cohort study has a high likelihood of making a significant impact on the clinical care of youth with diabetes from all the major ethnic groups in the US and on national public health policy.

项目摘要 在青年中寻找糖尿病（搜索）是一项持续的多中心研究，其中包含最大，最大的研究 在美国，糖尿病的青年人口多样化。响应RFA-DP10-001， 组件B，搜索队列研究将通过继续研究的研究来利用这一独特的资源 搜索参与者以解决以下目的：1）评估患病率，发病率和风险因素 精选的慢性微血管（视网膜病变，肾病和自主神经病）和 糖尿病的大血管并发症（高血压，动脉僵硬）； 2）评估发病率和风险 糖尿病急性并发症的因素，包括严重的低血糖症和糖尿病性酮症酸中毒； 3） 进行死亡的监视； 4）确定护理障碍，护理质量和 过渡到成人护理会影响糖尿病相关的健康成果，包括生活质量。覆盖这些 目的，我们将专注于种族/种族和其他社会文化因素以及生化维度的影响 糖尿病类型，与糖尿病相关的健康结果。搜索队列研究将进行面对面 研究研究访问2002年或更晚于搜索参与者，糖尿病持续时间> 5年 基线数据完成（预期n = 3699）。在这项研究的病史期间，人体测量学， 将收集和分析生化，生理和调查数据。华盛顿搜索网站 包括5个Puget Sound县（King，Kitsap，Pierce，Thurston和Snohomish），西雅图和 塔科马。我们已经成功注册了3,700多名参与者，我们是第二大搜索 网站以调查总数和基线访问的总数完成。随访的响应率很高 访问以及华盛顿调查人员在糖尿病及其并发症中的重要专业知识，我们是 坚定地符合这项研究的目标。这项研究将利用 研究人群以识别传统临床的护理和健康结果过程中的差异 糖尿病类型；由美国的主要种族/族裔群体；并采用一种新颖的方法来隔离 传统的临床糖尿病类型通过病理生理维度。因此，搜索队列研究具有很高的 对所有主要种族的糖尿病青年的临床护理产生重大影响的可能性 美国和国家公共卫生政策的团体。