SYNTHESIS OF NEW ORGANIC MOLECULES TO ADDRESS IMPORTANT METAL-MEDIATED PROCESSES

合成新的有机分子以解决重要的金属介导的过程

• 批准号: 8168834
• 负责人: LIVIU M. MIRICA
• 金额: $ 1.07万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168834
• 关键词: Address; Alzheimer' s Disease; Amyloid; Amyloid deposition; Area; Biochemistry; Biological; Brain; Catalysis; Chemistry; Complex; Computer Retrieval of Information on Scientific Projects Database; Consumption; Copper; Economics; Enzymes; Funding; Goals; Grant; Growth; Heme Iron; Hydrogen; Inorganic Chemistry; Institution; Investigation; Ions; Iron; Mediating; Medical; Metals; Molecular; Neurodegenerative Disorders; Organic Chemistry; Oxygen; Patients; Peptides; Population; Process; Reaction; Reactive Oxygen Species; Research; Research Personnel; Resources; Role; Senile Plaques; Societies; Solar Energy; Source; Students; Substrate Specificity; System; Transition Elements; United States National Institutes of Health; Water; Zinc; base; career; catalyst; design; enzyme substrate; inhibitor/antagonist; interest; knowledge base; oxidation; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research program uses inorganic chemistry, organic chemistry, and biological chemistry to address important metal-mediated processes with energy, biological, and medical relevance. An interdisciplinary, problem-based approach will be employed to synthesize and characterize new organic molecules and inorganic complexes, with the ultimate goal to tackle unsolved problems with broad implications to our society. Three main research areas will be pursued, which are expected to attract students and postdocs with different research interests and to provide them with a broad knowledge base applicable in most chemistry careers. Non-Heme Iron Enzymes. Non-heme iron enzymes catalyze a wide range of oxidation and oxygenation reactions. This project aims to design and synthesize specific inhibitors of O2-activating non-heme iron enzymes by taking advantage of the enzyme's substrate specificity. Renewable Energy Catalysis. The global energy consumption is expected to at least double in the next fifty years due to population and economic growth. In this context, there is a large interest in developing molecular systems that can capture solar energy and used it to produce oxygen and hydrogen from water. This project regards the design, synthesis, and characterization of polymetallic complexes as potential catalysts for water oxidation. Amyloid b Peptides in Alzheimer's Disease. Alzheimer's Disease (AD) is the most common neurodegenerative disease. The brains of patients with AD are characterized by the deposition of amyloid b (Ab) peptide plaques, which accumulate unusually high concentrations of copper, iron, and zinc. This project is directed toward the investigation of the interaction of transition metal ions with Ab peptides and the study of the role of metal ions in amyloid plaque and reactive oxygen species (ROS) formation

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们的研究项目利用无机化学、有机化学和生物化学来解决与能源、生物和医学相关的重要金属介导过程。将采用跨学科、基于问题的方法来合成和表征新的有机分子和无机复合物，最终目标是解决对我们社会具有广泛影响的未解决问题。将开展三个主要研究领域，预计将吸引具有不同研究兴趣的学生和博士后，并为他们提供适用于大多数化学职业的广泛知识基础。 非血红素铁酶。非血红素铁酶催化多种氧化和氧合反应。本项目旨在利用O2激活非血红素铁酶的底物特异性，设计并合成该酶的特异性抑制剂。 可再生能源催化。由于人口和经济增长，预计未来五十年全球能源消耗至少翻一番。在这种背景下，人们对开发能够捕获太阳能并利用其从水中产生氧气和氢气的分子系统产生了很大的兴趣。该项目将多金属配合物的设计、合成和表征视为水氧化的潜在催化剂。 阿尔茨海默病中的 b 淀粉样蛋白肽。阿尔茨海默病（AD）是最常见的神经退行性疾病。 AD 患者大脑的特点是淀粉样蛋白 b (Ab) 肽斑块的沉积，这些斑块积累了异常高浓度的铜、铁和锌。该项目旨在研究过渡金属离子与抗体肽的相互作用以及金属离子在淀粉样斑块和活性氧（ROS）形成中的作用