Aquatic Biomedical Models Facility CORE

水生生物医学模型设施核心

基本信息

批准号：
8057629
负责人：
Robyn L Tanguay
金额：
$ 21.47万
依托单位：
OREGON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-23 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8057629
关键词：
Adult Age Analytical Chemistry Animals Arts Autopsy Behavior assessment Binding Sites Biological Biological Assay Biological Markers Biology Carcinogens Cells Chemical Exposure Chemicals Chemoprevention Collaborations Communication Core Facility Data Databases Deposition Development Devices Disease Dose Electron Microscope Embryo Embryo Transfer Engineering Environment Equipment Experimental Designs Family Female Gene Expression Gene Silencing Gene-Modified Genes Genetic Genetic Screening Genome Germ Lines Goals Health Sciences Hour Human Resources Image In Situ Hybridization Institutes Investments Laboratories Laboratory Research Legal patent Lesion Licensing Mammals Mass Spectrum Analysis Methods Microfluidics Microinjections Mission Modeling Molecular Molecular Analysis Mutation Oncorhynchus mykiss Oregon Pathway interactions Physiologic pulse Play Population Predisposition Process Productivity Proteins Proteomics Protocols documentation Quarantine Records Research Research Personnel Resistance Resources Role Scientist Screening procedure Services Signal Transduction Site Sorting - Cell Movement Stable Isotope Labeling Staging System Techniques Technology Testing Toxicity Tests Transgenes Transgenic Organisms Translational Research United States National Academy of Sciences United States National Institutes of Health Universities Visit Water Work Zebrafish Zinc Fingers base biocomputing carcinogenesis chemical genetics cost data sharing design dietary supplements digital egg embryonic stem cell environmental stressor experience fetal follow-up gene repression genome-wide human disease improved interest meetings micromanipulator mutant nanolitre novel novel therapeutic intervention nuclease pathogen pressure professor programs prototype research study response sperm cell success transmission process zebrafish genome

项目摘要

The mission of Aquatic Biomedical Models Facility Core (ABMFC) is to exploit the unique advantages of aquatic models to discover the environmental-biological interactions that influence the development of human disease. The ABMFC is dedicated to achieving these long-term goals: ¿ understand the full suite of environmental stressors that interact with and perturb the "normal" developmental program, define the genes that play a role in increased susceptibility to environmental stressors, ¿ identify early and predictive biomarkers of human disease and discover novel therapeutic interventions, ¿ define the optimal fetal environment that reduces lifelong susceptibility to disease, and ¿ expand the use of chemical genetics to understand the mode of action of environmental stressors.

水生生物医学模型设施核心（ABMFC）的使命是探索水生模型的独特优势，以发现影响人类疾病发展的环境生物学相互作用。 ABMFC致力于实现这些长期目标： »了解与“正常”发展计划相互作用并扰动的环境压力源的完整套件，定义在增加对环境压力源的敏感性中发挥作用的基因， �确定人类疾病的早期和预测性生物标志物，并发现新的治疗干预措施， »定义最佳的胎儿环境，以降低终身对疾病的敏感性，并 »扩大化学遗传学的使用以了解环境压力源的作用方式。