Basic applications for total-body PET in oncology

全身 PET 在肿瘤学中的基本应用

• 批准号: 10017942
• 负责人: RAMSEY D. BADAWI
• 金额: $ 62.09万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-12 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017942
• 关键词: Affect; Attention; Breathing; California; Clinical; Clinical Management; Clinical Oncology; Collaborations; Data; Data Set; Devices; Diagnostic; Diagnostic Imaging; Discipline of Nuclear Medicine; Dose; Enrollment; Equilibrium; Equipment; Fasting; Funding; Goals; Hour; Human; Human body; Image; Injections; Investments; Learning; Lesion; Low Dose Radiation; Lymphoma; Malignant neoplasm of lung; Noise; Oncologist; Oncology; PET/CT scan; Pathology; Patient Care; Patients; Performance; Physicians; Population; Positron-Emission Tomography; Protocols documentation; Radiation therapy; Radiology Specialty; Reporting; Scanning; Signal Transduction; Staging; Technology; Time; Universities; attenuation; cancer imaging; clinical application; clinical practice; cohort; cost effective; fluorodeoxyglucose positron emission tomography; low dose computed tomography; melanoma; meter; radiotracer; recruit; simulation; tumor; uptake

Abstract: The EXPLORER Consortium, through funding via a Transformative R01 and substantial commercial investment, has developed a 2-meter long total body PET scanner. This device has the potential to significantly alter the clinical application of PET through (a) substantial reduction in scan times, (b) substantial improvements in image quality, (c) substantial reduction in administered activity and (d) total-body coverage. This proposal aims to answer the basic questions that this new equipment raises with respect to the current clinical oncology application space: (1) how fast a scan can be performed to obtain standard diagnostic images using total-body PET; (2) whether breath-hold PET is feasible; (3) whether the scanner will support a 25-fold reduction in administered radiotracer activity; (4) whether there is value in delaying imaging to much later time-points after injection than current practice and (5) if the improvements in image quality obtained using standard injected doses and scan times have clinical utility. We will enroll 360 subjects from the clinical oncologic population seen at University of California, Davis; specifically, subjects affected by lung cancer, lymphoma and melanoma referred for PET/CT scan initial staging will be enrolled before starting treatment. We expect that the EXPLORER total-body PET scanner will be able to perform studies of similar diagnostic quality to conventional PET/CT scanners in approximately a minute or using a reduced dose corresponding to 1/25th of the standard dose. In addition we predict that breath-hold examinations will be feasible on EXPLORER. We also predict that very late time point imaging will be feasible on EXPLORER resulting in potential gains in lesion conspicuity. Finally, in collaboration with a team of highly-qualified team with expertise in oncology, radiation therapy, radiology and pathology, we will collect initial data to assess the added value of high-quality EXPLORER scans in oncologic imaging compared to conventional PET/CT scanners.

抽象的： EXPLORER 联盟通过 Transformative R01 和大量商业资金提供资金 投资开发了2米长的全身PET扫描仪。该设备有潜力显着 通过 (a) 大幅减少扫描时间，(b) 大幅减少扫描时间，改变 PET 的临床应用 图像质量的改善，(c) 管理活动的大幅减少以及 (d) 全身覆盖。 该提案旨在回答该新设备提出的有关以下方面的基本问题： 当前的临床肿瘤学应用空间：(1) 扫描获得标准诊断的速度有多快 使用全身 PET 成像； (2)屏气PET是否可行； (3) 扫描仪是否支持 所施用的放射性示踪剂活性减少 25 倍； (4) 过度延迟成像是否有价值 注射后的时间点比当前实践晚，以及 (5) 图像质量是否获得改善 使用标准注射剂量和扫描时间具有临床实用性。 我们将从加州大学戴维斯分校的临床肿瘤人群中招募 360 名受试者； 具体来说，受肺癌、淋巴瘤和黑色素瘤影响的受试者首先转诊进行 PET/CT 扫描 开始治疗前将进行分期登记。 我们预计 EXPLORER 全身 PET 扫描仪将能够进行类似的研究 大约一分钟或使用减少的剂量即可达到传统 PET/CT 扫描仪的诊断质量 相当于标准剂量的1/25。此外，我们预计屏气检查将 在 EXPLORER 上可行。我们还预测极晚时间点成像在 EXPLORER 上将是可行的 导致病变明显性的潜在收益。最后与高素质团队合作 凭借肿瘤学、放射治疗、放射学和病理学方面的专业知识，我们将收集初始数据来评估 与传统 PET/CT 相比，高质量 EXPLORER 扫描在肿瘤成像中的附加值 扫描仪。