Core B: Research Translation Core

核心 B：研究翻译核心

• 批准号: 9149241
• 负责人: Thomas M Burbacher
• 金额: $ 9.31万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9149241
• 关键词: Alzheimer' s Disease; Biological Assay; Biological Markers; Cadmium; Centers for Disease Control and Prevention (U.S.); Child; Communication; Communities; Continuing Education; Data Collection; Ecology; Educational Materials; Educational workshop; Ensure; Environmental Exposure; Funding; Goals; Government Agencies; Individual; Journals; Legal patent; Manganese; Measures; National Institute of Environmental Health Sciences; Neurodegenerative Disorders; Neurodevelopmental Disorder; Outcomes Research; Parkinson Disease; Patients; Pesticides; Predisposition; Protocols documentation; Public Health; Reporting; Research; Research Personnel; Rotation; Schedule; Science; Scientific Advances and Accomplishments; Signal Recognition Particle; Site; South Africa; Superfund; Support Groups; System; Techniques; TimeLine; Training; Translational Research; Work; abstracting; adult neurogenesis; base; commercialization; community organizations; data sharing; improved; interest; meetings; member; neurotoxic; pesticide exposure; programs; remediation; symposium; water quality

Abstract The Research Translation Core (RTC) will partner with the Community Engagement Core (CEC) to help implement the various data sharing and IIRT plans for the individual projects and cores. During the next funding cycle, the RTC will assist Dr. Gallagher (Project 1) in developing material and scheduling presentations on the results of his studies to community members and agencies responsible for site remediation. The RTC will assist Dr. Xia with her new biomedical project focused on the effects of cadmium exposure on adult neurogenesis (Project 2). We will build on Dr Xia's previous activities focused on support groups for patients with neurodegenerative diseases such as Parkinson's and Alzheimer's. Dr. Furlong (Project 3) is Co-director of the RTC and is our primary contact with the UW's Center for Commercialization (C4C). Dr.Furlong will continue to share his expertise regarding PON1 status assays with investigators involved in pesticide exposure research. He will also continue his work with ATSDR and CDC in developing new protocols for measuring OP exposures and will work with these organizations and EPA regarding the implications of the results of his studies regarding children's increased susceptibility to OP pesticides. We will assist the investigators of the two new site based projects, Dr. Racette (Project 4) and Dr. Neumann (Project 5), who have already developed ties with community organizations and regulatory agencies working on their study sites. For Project 4, we have added Dr. Nelson to our RTC staff to help build upon their successful work in the communities surrounding the Manganese (Mn) emitting smelter in Meyerton, South Africa. RTC staff will develop appropriate educational materials related to Mn exposure and effects and will share the results of the study as it unfolds. RTC staff will also work with Drs. Racette and Nelson to ensure the latest findings of the study are shared with the Department of Environmental Affairs. For Project 5, we will use our strong ties with the State Department of Ecology (the agency responsible for developing remediation strategies for the lake) and EPA Region 10 to provide lay-friendly material related to the objectives of the study and the potential implications of the results for site remediation and water quality standards. RTC staff will work with the Training Core to include trainees in activities, such as involvement in our Science and the Public journal club and developing materials for their community engagement rotations. The RTC will coordinate the activities of all investigators and cores in developing and executing our Continuing Education Courses in years 2 and 4. Advances in research in environmental exposures and neurodevelopmental and neurodegenerative disorders will be the focus of the initial course. Investigators will also be involved in the Workshops, Summits, and Webinars that the CEC will host. Finally, RTC staff will utilize the SRP Community Engagement/Research Translation Data Collection Form reporting system developed by the NIEHS to ensure all research advances and community engagement activities are reported.

抽象的 研究翻译核心（RTC）将与社区参与核心（CEC）合作，以帮助 为各个项目和核心实施各种数据共享和IIRT计划。在下一个 资金周期，RTC将协助Gallagher博士（项目1）开发材料和调度演示文稿 关于他对负责现场修复的社区成员和机构的研究结果。 RTC 将协助Xia博士进行她的新生物医学项目，重点介绍镉暴露对成人的影响 神经发生（项目2）。我们将基于Xia博士以前的活动，专注于患者的支持小组 帕金森氏症和阿尔茨海默氏症等神经退行性疾病。 Furlong博士（项目3）是 RTC是我们与UW的商业化中心（C4C）的主要接触。 Furlong博士将继续 与参与农药暴露的调查人员分享他关于PON1状态测定的专业知识 研究。他还将继续与ATSDR和CDC一起开发用于测量OP的新协议 暴露并将与这些组织和EPA合作就其结果的影响 有关儿童对OP农药敏感性增加的研究。我们将协助两者的调查人员 新的基于网站的项目，赛车博士（项目4）和诺伊曼博士（项目5），他们已经开发了 与社区组织和监管机构联系在其研究地点工作。对于项目4，我们有 将尼尔森博士添加到我们的RTC员工中，以帮助他们在周围的社区中成功工作 锰（MN）在南非的梅耶顿发出冶炼厂。 RTC员工将发展适当的教育 与MN暴露和影响有关的材料，将在研究结果时分享研究结果。 RTC工作人员会 也与Drs一起工作。 Racette和Nelson确保研究的最新发现与 环境事务部。对于项目5，我们将与州部的牢固联系 生态学（负责为湖泊制定补救策略的机构）和EPA第10区 提供与研究目标有关的外行友好材料以及结果的潜在含义 用于现场修复和水质标准。 RTC工作人员将与培训核心合作，包括受训者 在活动中，例如参与我们的科学和公共期刊俱乐部，并为其开发材料 社区参与轮换。 RTC将协调所有调查人员和核心的活动 在第2年和4年内开发和执行我们的继续教育课程。 环境暴露以及神经发育和神经退行性疾病将成为 初始课程。调查人员还将参与CEC将会参与研讨会，峰会和网络研讨会 主持人。最后，RTC工作人员将利用SRP社区参与/研究翻译数据收集 NIEHS开发的形式报告系统旨在确保所有研究进展和社区参与 活动报告。