Dedicated High-Performance Breast PET/CT

专用高性能乳房 PET/CT

基本信息

批准号：
8233753
负责人：
RAMSEY D. BADAWI
金额：
$ 2.37万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-15 至 2014-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8233753
关键词：
3-Dimensional Address Anatomy Area Axilla Behavior Benchmarking Biological Models Biopsy Blood Vessels Breast Breast Cancer Treatment Cancer Patient Characteristics Chest wall structure Clinic Clinical Communities Computer software Data Detection Devices Disease Drops Electronics Ensure Health Histology Human Hybrids Image Imaging Device Label Life Low Dose Radiation Magnetic Resonance Imaging Malignant Neoplasms Mammary Gland Parenchyma Mammography Mastectomy Measurement Measures Metabolic Methodology Methods Modeling Molecular Newly Diagnosed Noise Nuclear Operating System Operative Surgical Procedures Output PET/CT scan Patient Care Patients Performance Pharmaceutical Preparations Phase Play Population Positioning Attribute Positron-Emission Tomography Predictive Value Problem Solving Process Radioisotopes Reading Reporting Research Infrastructure Research Personnel Resolution Role Scheme Source Staging Staining method Stains System Techniques Technology Testing Therapeutic Three-Dimensional Image Time Tissues Tracer Translating Translations Tube Validation Woman Work analog attenuation base clinical efficacy cost data acquisition design detector drug development fluorodeoxyglucose positron emission tomography follow-up image reconstruction imaging modality improved in vivo malignant breast neoplasm molecular imaging mortality novel performance tests photomultiplier prototype reconstruction response scale up simulation therapy development tool

项目摘要

Objectives: To build a high-performance, high-resolution quantitative PET/CT scanner dedicated to imaging the breast. This will permit validation of anato-metabolic imaging of the breast in the contexts of local staging, prediction of therapeutic response, follow-up for patients receiving conservative therapy and the development of new drugs for breast cancer treatment. Methods: Using a novel high-resolution, low-dead-time scintillation detector design using a dual-ended read-out scheme using APDs and PSPMTs, and a modified version of commercial PET electronics, we will build a PET scanner compact enough to fit inside the gantry of our existing breast CT scanner. We will combine the two devices to allow sequential imaging of the breast in the same clinical setting, resulting in accurately registered high-resolution functional and anatomic images. The device will be compatible with biopsy tools and will be expandable to facilitate imaging of the chest wall and axillae. Construction will be phased. At each stage we will use a continuous test/re-test approach using pre-calculated bench-marks to permit efficient and timely resolution of arising issues. We will employ state-of-the-art image reconstruction techniques using measured system models to maximize spatial resolution, and we will carefully implement all necessary data corrections for quantitative imaging. We will compare performance with whole-body PET/CT and MRI in a trial of 30 patients with known breast cancer. Health relatedness: Breast PET imagers tested in the clinic to date are low-cost, low -performance devices that cannot adequately assess the methodology in vivo, and do not provide 3D images fused with 3D anatomic information (a technique that is well- proven in the body). Thus the known power of molecular imaging in staging and re- staging, response to therapy studies and drug development is not available to a large fraction of women with primary breast cancer. The proposed device will solve this problem and allow the determination of the minimum imaging requirements for adequate clinical performance - a pre-requisite for translation of this technology into patient care.

目标：构建高性能、高分辨率定量 PET/CT 扫描仪致力于乳房成像。这将允许验证解剖代谢成像乳房局部分期、治疗反应预测、随访对于接受保守治疗的患者以及乳腺新药的开发癌症治疗。方法：采用新颖的高分辨率、低死区时间闪烁探测器设计使用 APD 和 PSPMT 的双端读出方案以及修改版本商用 PET 电子产品，我们将制造一台足够紧凑、可安装在内部的 PET 扫描仪我们现有的乳腺 CT 扫描仪的机架。我们将结合这两个设备以允许在相同的临床环境中对乳房进行连续成像，从而获得准确的结果注册的高分辨率功能和解剖图像。该设备将兼容配有活检工具，可扩展以方便胸壁成像腋窝。建设将分阶段进行。在每个阶段我们都会使用连续测试/重新测试使用预先计算的基准的方法可以有效、及时地解决问题产生的问题。我们将采用最先进的图像重建技术测量系统模型以最大化空间分辨率，我们将仔细实施定量成像的所有必要的数据校正。我们将比较性能在一项对 30 名已知患有乳腺癌的患者进行的试验中，使用全身 PET/CT 和 MRI 进行了研究。健康相关性：迄今为止在诊所测试的乳房 PET 成像仪成本低廉，无法充分评估体内方法的低性能设备，以及不提供与 3D 解剖信息融合的 3D 图像（一种成熟的技术）已在体内得到证实）。因此，分子成像在分期和重新定位方面的已知能力大量患者无法获得分期、对治疗研究和药物开发的反应患有原发性乳腺癌的女性比例。所提出的设备将解决这个问题问题并允许确定足够的最低成像要求临床表现——将该技术转化为患者护理的先决条件。