Triglycerides and Triglyceride-Rich Particles in Health and Disease

健康和疾病中的甘油三酯和富含甘油三酯的颗粒

• 批准号: 7804073
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-05 至 2011-01-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7804073
• 关键词: Academia; Adipose tissue; Affect; Anabolism; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Atherosclerosis; Biology; Cells; Chylomicrons; Clinical; Clinical Sciences; Clinical Trials; Coronary Arteriosclerosis; Data; Development; Disease; Genetic; Health; Hypertriglyceridemia; Industry; Insulin; Intestines; Lipids; Lipolysis; Lipoproteins; Liver; Medicine; Metabolism; Molecular Biology; Montana; Nonesterified Fatty Acids; Pathogenesis; Pharmacological Treatment; Play; Population; Regulation; Research; Role; Science; Scientist; Skiing; Tissues; Triglycerides; Update; Very low density lipoprotein; base; cardiovascular disorder risk; clinically relevant; cytokine; energy balance; insight; meetings; particle; public health relevance; symposium

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled Triglycerides and Triglyceride- Rich Particles in Health and Disease, organized by Robert H. Eckel, Ira J. Goldberg and Ruth McPherson, which will be held in Big Sky, Montana from January 9 - 14, 2010. Triglycerides are important storage molecules that play important roles in lipid and lipoprotein metabolism, insulin action, energy balance, and atherosclerosis. The purpose of this meeting will be to critically examine the broad spectrum of triglyceride biology from the molecular biology of triglyceride biosynthesis in the liver and intestine to lipoprotein assembly and secretion to lipid fuel partitioning to adipose tissue, muscle and the liver. A discussion of the regulation of free fatty acid flux from adipose tissue to the liver by insulin and pro- and anti-inflammatory cytokines will precede a detailed coverage of chylomicron and VLDL transport, intravascular lipolysis and tissue-specific lipid partitioning. A transition to the science and medicine of triglycerides will then occur with expected updates on the understanding of the genetic basis of disorders of triglyceride-rich lipoprotein metabolism and the pathogenesis of atherosclerosis that relate specifically to circulating triglyceride-rich particles. The clinical relevance of hypertriglyceridemia, new insights into the mechanisms of pharmacological treatment of hypertriglyceridemia, and clinical trial evidence pro and con that triglyceride lowering reduces cardiovascular disease risk will follow. The meeting should attract basic, clinical, and population scientists from academia and industry, and will deal with the many issues that remain unclear or controversial surrounding triglycerides and triglyceride rich particles in health and disease. PUBLIC HEALTH RELEVANCE: Research suggests that triglycerides are a cause of greater coronary artery disease; however, significant questions remain as to whether or not reducing triglyceride levels is protective. Moreover, the data relating the most severe forms of hypertriglyceridemia to development of atherosclerosis are limited. This Keystone Symposia meeting on Triglycerides and Triglyceride-Rich Particles in Health and Disease will assemble leading scientists to discuss 1) the clinical science on causes and treatment of hypertriglyceridemia, and 2) how triglycerides are regulated and affect biology in animals and cells.

描述（由申请人提供）： 该建议是要求支持Keystone研讨会会议，题为“甘油三酸酯和甘油三酸酯 - 健康与疾病中富含甘油三酸酯的颗粒”，由罗伯特·H·埃克尔（Robert H.动作，能量平衡和动脉粥样硬化。这次会议的目的是批判性地检查肝脏和肠中甘油三酸酯生物合成的分子生物学的广泛甘油三酸酯生物学，从而向脂蛋白组装到脂质蛋白组装以及分泌脂质燃料分配到脂肪燃料，从而脂肪糖组织，肌肉和肌肉，肌肉和肝脏。讨论通过胰岛素以及促炎和抗炎细胞因子从脂肪组织到肝脏的游离脂肪酸通量的讨论将先于乳糜微粒和VLDL转运的详细覆盖，血管内脂肪解析以及组织特异性的脂质分析。然后，将对甘油三酸酯科学和医学的过渡进行预期的更新，以了解对富含甘油三酸酯的脂蛋白代谢的遗传基础的理解以及动脉粥样硬化的发病机理，这些发病机理与富含甘油三酸酯的颗粒特别相关。高甘油三酯血症的临床相关性，对高甘油三酯血症药理治疗机制的新见解以及临床试验证据Pro和CON降低了甘油三酸酯的降低心血管疾病风险。这次会议应吸引来自学术界和工业的基本，临床和人群科学家，并将处理许多在健康和疾病中尚不清楚或有争议的问题。公共卫生相关性：研究表明，甘油三酸酯是冠状动脉疾病更大的原因。但是，关于降低甘油三酸酯水平是否具有保护性仍然存在的重大问题。此外，将最严重的高甘油三酯血症与动脉粥样硬化发展有关的数据受到限制。这次有关甘油三酸酯和甘油三酸酯富含甘油三酸酯的颗粒的Keystone研讨会将组装领导科学家讨论1）关于高甘油三酯血症的原因和治疗的临床科学，以及2）如何调节甘油三酸酯，并影响动物和细胞的生物学。