9th International Conference on Brain Energy Metabolism

第九届国际脑能量代谢会议

• 批准号: 7912757
• 负责人: MARY C MCKENNA
• 金额: $ 1.6万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-15 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7912757
• 关键词: Area; Astrocytes; Brain; Brain Diseases; Cell physiology; Cells; Collaborations; Communication; Communities; Cytosol; Degenerative Disorder; Diabetes Mellitus; Disease; Drug Formulations; Energy Metabolism; Ensure; Event; Failure; Fostering; Generations; Goals; Hour; Hungary; International; Journals; Knowledge; Laboratories; Metabolic; Mitochondria; Neurodegenerative Disorders; Neurons; Parkinson Disease; Pathogenesis; Peer Review; Production; Reaction; Research; Research Personnel; Scientist; Series; Signal Transduction; Speed; Stroke; Students; Time; Traumatic Brain Injury; Universities; Work; brain metabolism; driving force; improved; interest; meetings; nervous system disorder; posters; programs; public health relevance; research study; symposium; tool

DESCRIPTION (provided by applicant): The 9th International Conference on Brain Energy Metabolism entitled "Mitochondrial-Cytosolic Interactions: From Energetics to Pathogenesis" will be held on July 7-10, 2010, at Semmelweis University, Budapest, Hungary (http://www.icbem-budapest-2010.org/). The program includes two keynote speakers and 25 invited speakers in six scientific sessions on topics that focus on specific aspects of the continuum from mitochondrial energetics and brain metabolism to the relationships of energy failure to pathogenesis of neurological diseases. Speakers include established experts and young investigators, with about 30% of the time allocated to each session for speaker-conferee discussions. Student-fellow presentations are an important aspect of the meeting and they are an effective tool to help bring a new generation of scientists into our community and foster their maturation by their inclusion as young investigator speakers and session chairs. In addition, there are three poster sessions for a total of 7.5 hours to ensure plenty of informal discussion time with presentations by conferees. This conference focuses on intracellular communication between the cytosol and mitochondria, which is an under-studied topic that is critical for metabolic, biosynthetic, signaling, regulatory, and energetic aspects of neuronal and astrocytic function, as well as neuron-astrocyte interactions. The reactions, fluxes, transporters, and regulatory signaling aspects of cytosolic-mitochondrial interactions are poorly understood by neuroscientists in spite of their central importance to cellular function and disease. The major goal of this conference is, and has historically been, to serve as a driving force for cutting-edge discussions and formulation of incisive experiments and collaborations that open new areas of exploration of energy metabolism that underlie and contribute to brain diseases, including stroke, degenerative diseases, and traumatic brain injury. This goal will be achieved by a small, focused conference (about 100-120 attendees) that centers around brain energy metabolism and brings together the world's experts, students, and fellows who have a keen interest in this field. Formal presentations and informal discussions are highlights of this conference series that fosters long-term scientific interactions and disseminates original research work and review articles by the conferees in a peer-reviewed special issue of a scientific journal. PUBLIC HEALTH RELEVANCE: The Brain Energy Metabolism conference is a 4-day scientific educational event in which conference attendees will convey cutting-edge results of research related to brain diseases that involve energy production and mitochondria, the powerhouses of cells that generate most of the energy. Diseases such as stroke, diabetes, Parkinson's disease, and other neurodegenerative diseases all have serious disturbances of energy production as an underlying feature, and sharing knowledge with others improves research and speeds the transfer of potential treatments from the laboratory to bedside.

描述（由申请人提供）：题为“线粒体-细胞质相互作用：从能量学到发病机制”的第九届脑能量代谢国际会议将于 2010 年 7 月 7-10 日在匈牙利布达佩斯 Semmelweis 大学举行 (http:// www.icbem-budapest-2010.org/）。该计划包括 6 场科学会议中的 2 名主讲人和 25 名受邀演讲者，其主题侧重于从线粒体能量学和脑代谢到能量衰竭与神经系统疾病发病机制的关系的连续体的特定方面。演讲者包括知名专家和年轻研究者，每场会议大约有 30% 的时间用于演讲者与与会者的讨论。学生同事的演讲是会议的一个重要方面，它们是一个有效的工具，可以帮助将新一代科学家带入我们的社区，并通过让他们作为年轻研究者的演讲者和会议主席来促进他们的成熟。此外，还有三场海报会议，总计 7.5 小时，以确保与会者有充足的非正式讨论时间和演示。本次会议重点讨论细胞质和线粒体之间的细胞内通讯，这是一个尚未充分研究的主题，对于神经元和星形胶质细胞功能的代谢、生物合成、信号传导、调节和能量方面以及神经元-星形胶质细胞相互作用至关重要。尽管细胞质-线粒体相互作用的反应、通量、转运蛋白和调节信号传导对于细胞功能和疾病至关重要，但神经科学家对其了解甚少。本次会议的主要目标是，并且一直以来都是作为前沿讨论和深入实验与合作的制定的驱动力，从而开辟能量代谢探索的新领域，这些能量代谢是脑疾病（包括中风）的基础和促成因素、退行性疾病和创伤性脑损伤。这一目标将通过一次小型、集中的会议（约 100-120 名与会者）来实现，该会议以大脑能量代谢为中心，汇集了世界各地对该领域有浓厚兴趣的专家、学生和研究员。正式演讲和非正式讨论是该会议系列的亮点，旨在促进长期的科学互动，并在同行评审的科学期刊特刊上传播与会者的原创研究工作和评论文章。 公共健康相关性：脑能量代谢会议是一个为期 4 天的科学教育活动，与会者将传达与涉及能量产生和线粒体（产生大部分能量的细胞动力室）的脑部疾病相关的前沿研究成果。中风、糖尿病、帕金森病和其他神经退行性疾病等疾病都以严重的能量产生紊乱为基本特征，与他人分享知识可以改善研究并加快潜在治疗方法从实验室到临床的转移。