2010 Cardiac Regulatory Mechanisms Gordon Research Conference

2010年心脏调节机制戈登研究会议

• 批准号: 7905509
• 负责人: JOAN HELLER BROWN
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905509
• 关键词: Area; Arrhythmia; Cardiac; Cardiac Myocytes; Cardiovascular system; Charge; Development; Diagnosis; Discipline; Disease; Fostering; Functional disorder; Funding; Future; Genetic; Genetically Modified Animals; Geography; Health; Heart; Heart Diseases; Image; Knockout Mice; Lead; Learning; Mechanics; Mitochondria; Molecular; Muscle Cells; Nature; Oral; Pacemakers; Participant; Phenotype; Prevention; Process; Property; Publications; Recruitment Activity; Regulation; Research; Research Personnel; Resolution; Role; Science; Scientist; Signal Pathway; Signal Transduction; Social Interaction; Staging; Time; Transgenic Organisms; Translating; base; career; college; experience; interest; mouse model; new technology; novel; novel therapeutics; planetary Atmosphere; posters; public health relevance; scaffold; symposium

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) on "Cardiac Regulatory Mechanisms" to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 6-11, 2010. For more than 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The special informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Accordingly an extraordinarily high number of scientists return to this conference year after year. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. Their bond is a common interest in the topic of regulation of the normal and diseased heart with a focus on Ca regulatory mechanisms. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including mitochondrial Ca regulation, novel mechanisms of ER signal transduction, subcellular compartments, scaffolds and their real time imaging, and the still controversial role of InsP3 in the heart. Other sessions focus on arrhythmias/pacemaker function, Ca signaling in myocytes and novel signaling pathways. Discussion leaders are charged with and are historically successful at promoting lively discussions and critical questioning. Indeed a key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of unresolved issues. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies that allow us to explore the cellular and molecular bases of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect the proposed presentations to be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience. PUBLIC HEALTH RELEVANCE: Important advances in science depend on the open exchange of the latest ideas and new findings. The Gordon Research Conference (GRC) on Cardiac Regulatory Mechanisms enables and catalyzes such exchange. The health relatedness of the conference is evident in the nature of the research presentations which focus on understanding how normal cardiac function is regulated and how it becomes dysregulated in disease. Resolution of these issues, as advanced by the talks and discussion, will direct future research and ultimately lead to the development of new therapeutic strategies to treat heart disease.

描述（由申请人提供）： 该应用程序于2010年6月6日在Colby Sawyer College（NH Colby-Sawyer，NH）在Gordon研究会议（GRC）上寻求部分资金，该会议将于2010年6月6日至11日在Colby Sawyer College（NH Colby-Sawyer）举行。这次会议多25年以来，这次会议一直自豪地自豪地召集了新的调查员并培养了最新的未公开发现和互动的领导者，并介绍了他们的有意义的科学和社交互动和社交。 GRC的特殊非正式性质在促进跨越学科和地理的讨论中是独一无二的，并使新的个人和科学联系得以发展。因此，一年一度的科学家数量非常高。参与者是从职业生涯和各种学科的所有阶段中最有前途，最有生产力的科学家中选择的。他们的纽带是对正常和患病心脏的监管主题的共同兴趣，重点是CA调节机制。在这些过程中，我们具有与正常心脏电气和机械性能，心肌细胞信号传导和异常相关的基本科学的良好结合，这些过程会导致心脏功能障碍。转基因动物的使用增加以及确定的心血管表型的发展使心血管系统可拖拉，从而引起了细胞信号传导场的广泛和扩展。今年的会议特别关注信号通路，包括一些强烈的研究兴趣的新领域，包括线粒体CA调节，ER信号转导的新型机制，亚细胞隔室，脚手架及其实时成像，以及INSP3在心中仍然有争议的作用。其他会议的重点是心律不齐/起搏器功能，心肌细胞中的CA信号传导和新型信号通路。讨论负责人被指控，并在历史上成功地促进了活泼的讨论和批判性质疑。确实，这次会议的关键目标是培养一种包容性，强烈，生动和互动性的氛围，该氛围突出了争议，并通过对未解决的问题有更深入的了解来启发参与者。在心血管科学中，这是一个令人兴奋的时刻，因为使用了转基因和基因敲除小鼠模型，遗传信息和新技术，使我们能够探索正常心脏功能的细胞和分子碱基。我们开始将这些新发现转化为对疾病机制，诊断，预防和治疗的更好理解。我们预计拟议的演讲既令人兴奋又及时，并通过招募海报贡献和最近出版物的发言人来包括晚期的破坏科学和年轻调查人员。这是那些经常参加会议的人，新的与会者和年轻科学家认为是无价的学习和职业经验。公共卫生相关性：科学的重要进展取决于最新想法和新发现的公开交流。关于心脏调节机制的戈登研究会议（GRC）可实现和催化这种交换。会议的健康相关性在研究演讲的性质中很明显，这些性质着重于了解正常心脏功能的调节以及在疾病中的调节方式。通过谈判和讨论提出的这些问题的解决将指导未来的研究，并最终导致发展新的治疗策略来治疗心脏病。