Low-Cost Device for Digital Retinal Imaging

用于数字视网膜成像的低成本设备

• 批准号: 7874577
• 负责人: ANN E ELSNER
• 金额: $ 33.64万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-05 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7874577
• 关键词: Animal Model; Anterior; Area; Blindness; Blood Vessels; Caliber; Caring; Cataract; Complications of Diabetes Mellitus; Contracts; Cornea; Cues; Cystoid Macular Edema; Data; Databases; Detection; Development; Devices; Diabetes Mellitus; Diabetic Retinopathy; Diagnostic Imaging; Disadvantaged; Early Diagnosis; Edema; Electronics; Elements; Engineering; Exudate; Eye; Eye Color; Failure; Fiber; Fundus; Future; Glaucoma; Goals; Growth; Human; Hybrids; Image; Imagery; Imaging Device; Imaging Techniques; Iris; Knowledge; Lasers; Lesion; Light; Lighting; Methods; Microaneurysm; Minority; Mydriatics; Ophthalmoscopes; Optics; Outcome; Pain; Patients; Photography; Pigmentation physiologic function; Pigments; Population; Price; Production; Provider; Pupil; Quality Control; Reading; Reproducibility; Research; Research Personnel; Resolution; Retina; Retinal; Retinal Detachment; Retinal Diseases; Risk; Scanning; Screening procedure; Series; Side; Signal Transduction; Solutions; Source; Specialist; Staging; Structure; Surrogate Markers; System; Techniques; Technology; Testing; Time; Traction; Training; Variant; Vision; Width; Work; base; cost; design; detector; diabetic cataract; diabetic patient; digital; field study; flexibility; health disparity; improved; laptop; light scattering; macula; macular edema; neovascularization; novel strategies; sensor; tool; two-dimensional; voltage

DESCRIPTION (provided by applicant): The goal of this research is to provide a low cost device for digital retinal imaging, the Laser Scanning Digital Camera, as an integral part of screening for diabetic retinopathy. This device will be unusually inexpensive and provide images with contrasts at least as high as those now used clinically. It will eventually provide the ease of use of a digital camera, minimizing current problems with training. This new technique will provide a long-awaited tool to basic researchers and clinicians alike for detecting diabetic retinopathy early, in an inexpensive and sensitive manner. Unlike recent devices with more than 30 % failure rate in the field, we anticipate use with every patient without severe corneal problems or severe cataracts. The Laser Scanning Digital Camera uses our unique hybrid system of slit-scanning the illumination, and detection by a 2- dimensional array with electronic aperture, using primarily low cost, off-the shelf components. We perform confocal imaging using a newly-demonstrated electronic aperture, which reduces scattered light from out-of-plane structures and thereby improves image contrast. We will test the flexibility of the electronic aperture to provide scattered light, i.e. dark field, imaging, as well as image averaging and image sharpening. The camera works with an undilated pupil, due to the small entrance/exit split pupil system and near infra-red light. All clinically important retinal vascular changes and macular edema have now been visualized by us with higher end devices, including microaneurysms and features in darkly pigmented eyes. Stereo imaging was recently shown to be unnecessary for detecting macular edema, and therefore we will provide high contrast images to obtain cues for judging macular edema. We will implement our technique from high end devices: scattered light imaging. Aim 1 is to complete the development of the Laser Scanning Digital Camera, including new imaging modes provided by the electronic aperture. Aim 2 will begin field work, with reproducibility studies and eye pigmentation comparisons in normal subjects and initial tests in patients with moderate nonproliferative diabetic retinopathy. We will use the electronic configuration to optimize the optical confocal aperture width. Aim 3 investigates confocal near infra-red imaging techniques, including real-time variation of aperture, image sharpening, and scattered light imaging, as applied to a population with the full range of retinal changes found in patients with diabetes. We anticipate enhanced detection capability for edematous lesions, e.g. cystoid macular edema. Aim 4 is to achieve motionless confocal scanning laser imaging, but still retain the movable part needed for focus, and compare this method to that used in Aim 3. We will also include an anterior segment imaging component, which is extremely inexpensive, as diabetic patients with dark eyes can have new vessel growth in the iris that leads to painful and sight-threatening glaucoma. This will also document eye color and provide help with quality control by giving the pupil diameter. While this project focuses on diabetic retinopathy in humans, future applications include other retinal disorders in both humans and animal models.

描述（由申请人提供）：这项研究的目的是为数字视网膜成像（激光扫描数码相机）提供低成本设备，这是糖尿病性视网膜病变筛查的组成部分。该设备将异常便宜，并提供至少与现在临床使用的图像相对高的对比度。它最终将提供数码相机的易用性，从而最大程度地减少培训当前问题。这项新技术将为早期的基础研究人员和临床医生提供一种期待已久的工具，以廉价且敏感的方式早期检测糖尿病性视网膜病。与最近在现场失效率超过30％的设备不同，我们预计每位患者都会使用而没有严重的角膜问题或严重的白内障。激光扫描数码相机使用我们独特的混合动力系统，用于缝制照明，并通过2维阵列用电子光圈进行检测，主要使用低成本，即架子上的架子组件。我们使用新示范的电子光圈进行共聚焦成像，该光圈降低了平面外结构的散射光，从而改善了图像对比度。我们将测试电子光圈的灵活性，以提供散射的光，即暗场，成像以及图像平均和图像锐化。由于小小的入口/出口分裂的学生系统和接近红外光线，该相机可与未灌输的学生一起使用。现在，所有具有临床上重要的视网膜血管变化和黄斑水肿已被我们的高端设备可视化，包括微型神经酶和深色的眼睛中的特征。立体成像最近被证明是检测黄斑水肿的不必要的，因此我们将提供高对比度图像以获得判断黄斑水肿的提示。我们将从高端设备中实施我们的技术：散射的光成像。 AIM 1是完成激光扫描数码相机的开发，包括电子光圈提供的新成像模式。 AIM 2将开始现场工作，对正常受试者进行可重复性研究和眼部色素沉着比较，并在中等非增强性糖尿病性视网膜病患者中进行初始测试。我们将使用电子配置来优化光学共聚焦光圈宽度。 AIM 3研究了近红外成像技术的共焦焦点，包括孔径的实时变化，图像锐化和散射光成像，应用于糖尿病患者的视网膜全部变化范围的人群。我们预计水肿病变的检测能力增强了，例如囊状黄斑水肿。 AIM 4是要实现一动不动的共聚焦扫描激光成像，但仍然保留了重点所需的可移动零件，并将这种方法与AIM 3中使用的方法进行比较。我们还将包括一个前部段成像组件，这是非常便宜的，因为糖尿病患者的黑眼睛患有黑眼睛的生长可以在IRIS中具有新的血管生长，从而导致疼痛和观光症和观察和观察到的Glaucoma。这还将记录眼睛的颜色，并通过给出学生直径为质量控制提供帮助。尽管该项目侧重于人类的糖尿病性视网膜病变，但未来的应用包括人类和动物模型中的其他视网膜疾病。

项目成果

Comparison of Cysts in Red and Green Images for Diabetic Macular Edema.

• DOI: 10.1097/opx.0000000000001010
• 发表时间: 2017-02
• 期刊: Optometry and vision science : official publication of the American Academy of Optometry
• 作者: Alhamami MA;Elsner AE;Malinovsky VE;Clark CA;Haggerty BP;Ozawa GY;Cuadros JA;Baskaran K;Gast TJ;Litvin TV;Muller MS;Brahm SG;Young SB;Miura M
• 通讯作者: Miura M