Predictors of Influenza-Associated Absenteeism and Impact of Vaccination in a Cohort of Guatemalan Agricultural Workers

危地马拉农业工人群体中流感相关缺勤的预测因素和疫苗接种的影响

基本信息

批准号：
10016186
负责人：
Daniel Olson
金额：
$ 18.64万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-11 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10016186
关键词：
Absenteeism Acute Age Agricultural Workers Alcoholism Appointment Area Banana Biological Biological Markers Caring Childhood Chronic Kidney Failure Clinic Clinical Clinical Data Clinical Trials Design Colorado Communicable Diseases Communities Competence Country Data Databases Detection Disease Effectiveness Elderly Enrollment Environment Epidemiology Future Genotype Guatemala Guatemalan Health Healthcare Human Development Illness Days Incidence Income Individual Infectious Disease Epidemiology Influenza Influenza A Virus, H1N1 Subtype Influenza vaccination K-Series Research Career Programs Laboratories Latin America Lead Longitudinal cohort study Measurable Measures Mediating Medical Mentors Mentorship Morbidity - disease rate Nutritional Onset of illness Outcome Outcome Measure Participant Pediatrics Perception Performance at work Population Prediabetes syndrome Pregnant Women Production Productivity Public Health Public Health Schools Quality of life Recommendation Registries Research Research Training Risk Rural Sampling Secondary to Sentinel Surveillance Serum Severities Severity of illness Site Specialist Symptoms System Testing Time Training United States Universities Vaccination Vaccines Vertebral column Wages Weight Work Workplace base biomarker panel burden of illness career development cohort comorbidity cost cost effective economic outcome effectiveness measure experience food insecurity global health health care economics high risk population improved influenza virus vaccine low and middle-income countries medical schools mid-career faculty mortality novel pandemic disease pandemic influenza patient oriented pediatric department pediatrician population health professor programs prospective research and development seasonal influenza secondary endpoint skills socioeconomics symposium trend vaccinology

项目摘要

PROJECT SUMMARY/ABSTRACT This is an application for a K23 Patient-Oriented Mentored Career Development award by Daniel Olson, MD. The proposed research will assess the clinical and socioeconomic impacts of influenza in a cohort of agricultural workers in Guatemala, evaluate clinical, biological, and socioeconomic predictors of influenza- associated absenteeism, and measure the effectiveness of workplace-based influenza vaccine in reducing disease and absenteeism. Candidate. Dr. Olson is a board-certified pediatrician and infectious disease (ID) specialist who is an Assistant Professor in the Department of Pediatrics at the University of Colorado (CU) School of Medicine, with a secondary appointment in the Department of Epidemiology in the Colorado School of Public Health. Training. Through hands-on mentored research, didactic coursework, and conferences/seminars, Dr. Olson’s K23 Career Development aims include: 1) Develop and formalize skills in clinical trial design and implementation, 2) Establish expertise in vaccinology, and 3) Obtain competencies to manage and develop a high quality global health research site. Mentors/Environment. Dr. Olson has assembled a diverse team of mentors, each with specific skills in his proposed research and career development aims. Dr. Edwin Asturias, an Associate Professor of Pediatric ID and Epidemiology at CU and the Jules Amer Chair of Community Pediatrics, will be his primary mentor. The remaining mentorship committee includes Dr. Lee Newman, Dr. Kathryn Edwards, Dr. May Chu, and Dr. Frederick Hayden, providing a diverse group of senior level mentors with broad experience and expertise. Research. Low- and middle-income countries (LMICs) continue to suffer a disproportionate burden of influenza disease. Workplace influenza vaccination programs may offer a cost-effective strategy to limit absenteeism and lost productivity due to influenza. Agricultural workers represent an economically strategic workforce in Latin America, and the drivers of illness-associated absenteeism, such as influenza, are unknown. The CU research site in Guatemala has an established cohort of 2,706 agricultural workers from a nearby banana plantation and a well-trained research team. To better understand the impact of influenza on agricultural workers and the drivers of work absenteeism, we aim to 1) Evaluate the clinical and socioeconomic impacts of influenza on a cohort of Guatemalan agricultural workers and determine predictors of work absenteeism due to influenza, and 2) Measure the effectiveness of influenza vaccination on disease incidence, absenteeism, and job performance in the same cohort. We hypothesize that influenza places a significant burden on agricultural workers, that specific clinical, biological, and socioeconomic predictors may be associated with greater absenteeism, and that a workplace-based influenza vaccine program will significantly reduce clinical disease and influenza-associated absenteeism.

项目概要/摘要这是丹尼尔·奥尔森医学博士提出的 K23 以患者为导向的指导职业发展奖的申请。拟议的研究将评估流感对一组人群的临床和社会经济影响危地马拉的农业工人评估流感的临床、生物学和社会经济预测因素相关缺勤，并衡量基于工作场所的流感疫苗在减少疾病和缺勤。 Olson 博士是一名候选人，是一名经过委员会认证的儿科医生和传染病 (ID) 专家，也是一名助理。科罗拉多大学 (CU) 医学院儿科教授科罗拉多公共卫生学院流行病学系的二次任命。培训。奥尔森博士通过实践指导研究、教学课程和会议/研讨会。 K23 职业发展目标包括： 1) 发展并规范临床试验设计和实施，2) 建立疫苗学专业知识，以及 3) 获得管理和开发疫苗学的能力高质量的全球健康研究网站。导师/环境。奥尔森博士组建了一支多元化的导师团队，每个人都拥有特定的技能。儿科 ID 副教授 Edwin Asturias 博士提出了研究和职业发展目标。 CU 的流行病学和流行病学以及社区儿科的 Jules Amer 主席将是他的主要导师。剩下的导师委员会成员包括 Lee Newman 博士、Kathryn Edwards 博士、May Chu 博士和 Dr. May Chu。 Frederick Hayden 提供了一群具有丰富经验和专业知识的多元化高级导师。低收入和中等收入国家（LMIC）继续承受着不成比例的负担。工作场所流感疫苗接种计划可能提供一种具有成本效益的策略来限制流感疾病。流感导致的缺勤和生产力损失代表着经济战略。拉丁美洲的劳动力以及流感等疾病相关缺勤的驱动因素尚不清楚。 CU 位于危地马拉的研究基地拥有 2,706 名来自附近地区的农业工人。香蕉种植园和训练有素的研究团队更好地了解流感对我们的影响。农业工人和缺勤的驱动因素，我们的目标是 1) 评估临床和社会流感对危地马拉农业工人群体的影响并确定工作预测因素因流感缺勤，以及 2) 衡量流感疫苗接种对疾病发生率的有效性，我们认为，流感对同一群体的缺勤率和工作表现具有重要影响。农业工人的负担，具体的临床、生物学和社会经济预测因素可能是与更大的缺勤率相关，并且基于工作场所的流感疫苗计划将显着减少临床疾病和流感相关的缺勤。