Seasonal Conjunctivitis Outbreak Reporting for Prevention and Improved Outcomes (SCORPIO)

季节性结膜炎爆发报告以预防和改善结果 (SCORPIO)

基本信息

批准号：
10571940
负责人：
Thuy A Doan
金额：
$ 40.49万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10571940
关键词：
Absenteeism at work Acute contagious conjunctivitis Address Adenoviruses Adult Animals Antibiotic Resistance Area Azithromycin Bacteria Biological Cessation of life Child Childhood Clinical Collaborations Conjunctivitis Cornea Country Detection Diagnostic Diagnostic tests Disease Disease Outbreaks Economic Burden Education Epidemic Epidemiology Etiology Evaluation Evolution Foundations Future Gastroenteritis Gene Expression Gene Expression Profile Genome Genomics Geographic Locations Goals Guidelines Health Healthcare Hospitalization Human Immune response Infection Infectious Agent Infrastructure International Internet Intervention Metagenomics Methods Molecular Diagnostic Techniques Natural Disasters Organism Outcome Pathogenesis Patient Care Patient-Focused Outcomes Patients Pattern Population Population Surveillance Prevention Quarantine Reporting Sampling Schools Seasons Sentinel Surveillance Site Social Network Swab Technology Time United States Vaccination Virus Visual impairment Wages acquired immunity age group care providers co-infection cost deep sequencing economic impact emerging pathogen fungus future epidemic improved improved outcome large datasets pathogen pathogen genome patient population prevent respiratory respiratory distress syndrome sample collection socioeconomics targeted treatment transmission process trend vaccine development

项目摘要

PROJECT SUMMARY/ABSTRACT Seasonal and epidemic conjunctivitis (pink eye) infections are highly contagious and impose significant economic burden in the United States and worldwide. Long-term visual impairment can occur. In children, conjunctivitis may herald more serious systemic complications leading to hospitalizations and even deaths. Current challenges to effective mechanisms to curtail outbreaks are the lack of tracking and reporting, poor access to sample collection for analysis, limited diagnostic testing capabilities, and an incomplete understanding of the pathogens involved. The overall goal of this project is to combine international collaboration efforts and advances in genomic technologies to identify pathogens, global trends, pathogen evolution, and the immune responses involved in the epidemiology of conjunctivitis. We propose to enhance the understanding of the pathogenesis of conjunctivitis with the following aims. The first aim will determine how adenovirus genome types vary within a region and across regions. The second aim will identify emerging causes of seasonal and epidemic conjunctivitis. Finally, we will identify the local immune response signatures of children and adults with infectious conjunctivitis. We expect that conjunctival gene expression profiles will accurately predict disease associated complications. This project has the potential to improve public health surveillance, guide targeted interventions, improve vaccine development, and elevate existing diagnostic paradigms for conjunctivitis, to reduce both the financial and ocular health burden worldwide.

项目概要/摘要季节性和流行性结膜炎（红眼病）感染具有高度传染性，并造成严重的后果美国和全世界的经济负担。可能会出现长期视力障碍。在儿童中，结膜炎可能预示着更严重的全身并发症，导致住院甚至死亡。当前遏制疫情的有效机制面临的挑战是缺乏跟踪和报告、获取用于分析的样本收集、有限的诊断测试能力以及不完整的信息了解所涉及的病原体。该项目的总体目标是结合国际基因组技术的合作努力和进步，以确定病原体、全球趋势、病原体进化以及结膜炎流行病学中涉及的免疫反应。我们建议加强了解结膜炎的发病机制有以下目的。第一个目标将决定如何腺病毒基因组类型在区域内和区域间有所不同。第二个目标将确定新兴的季节性和流行性结膜炎的原因。最后，我们将识别局部免疫反应特征患有传染性结膜炎的儿童和成人。我们预计结膜基因表达谱将准确预测疾病相关并发症。该项目具有改善公共卫生的潜力监测、指导有针对性的干预措施、改进疫苗开发并提升现有诊断水平结膜炎的范例，以减轻全世界的经济和眼部健康负担。