Administrative Core

行政核心

• 批准号: 10705296
• 负责人: Michelle Denburg
• 金额: $ 43.12万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-18 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705296
• 关键词: Acceleration; Address; Advisory Committees; Awareness; Basic Science; Big Data; Biological; Biomedical Research; Child; Childhood; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communities; Comparative Effectiveness Research; Data; Development; Education; Effectiveness; Electronic Health Record; Epidemiology; Faculty; Family; Feasibility Studies; Fostering; Foundations; Future; Genomics; Goals; Health Services Research; Health system; Individual; Informatics; Infrastructure; Institution; Interdisciplinary Study; International; Kidney Diseases; Knowledge; Leadership; Learning; Longevity; Mentors; Methods; Mission; Molecular; Multi-Institutional Clinical Trial; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Observational Study; Outcome; Patients; Pediatric Hospitals; Peer Review; Pennsylvania; Philadelphia; Pilot Projects; Policies; Positioning Attribute; Pragmatic clinical trial; Productivity; Records; Research; Research Methodology; Research Personnel; Research Project Grants; Sampling; Scholars Program; Talents; Therapeutic; Training; Translational Research; Universities; Vulnerable Populations; Work; base; career; career development; clinical investigation; clinical phenotype; clinical trial implementation; cohesion; community engagement; comparative effectiveness; comparative effectiveness trial; design; evidence base; experience; human subject protection; human tissue; improved; innovation; interest; medical schools; meetings; member; molecular phenotype; new therapeutic target; novel; organizational structure; pragmatic trial; prevent; programs; skills; success; transcriptomic profiling; virtual; web site

ADMINISTRATIVE CORE PROJECT SUMMARY The overall goal of the Administrative Core is to provide direction, guidance, and oversight for the PCEN and assure its effective and efficient functioning. The Administrative Core will facilitate the work of the two Biomedical Research Cores, the Learning Health System Core (LHS Core) and the Molecular Precision Nephrology Core (MPNC), and support the Enrichment Program, Opportunity Pool Pilot and Feasibility Program, and two Research Projects. The Enrichment Program aims to equip the research base with additional skill sets and maximizes interactions and intellectual discourse within the PCEN. Initiatives within the Enrichment Program will encourage and support innovative multidisciplinary research in pediatric kidney disease through early career engagement, including the Summer Scholar program; career development and collaborations; and patient, family, and community engagement. The Opportunity Pool Pilot and Feasibility Programwill continue to stimulate and solicit new project ideas to address key barriers to research progress in pediatric nephrology, specifically for early stage investigators, new investigators, or established investigators not previously involved in research on pediatric kidney disease. The CHOP PCEN organizational structure includes oversight by an External Advisory Board (EAB) and input and guidance from a Scientific Advisory Committee (SAC). The Steering Committee will set overall policy for the CHOP PCEN and will include the Center Co-Directors, the SAC Chair, the Biomedical Core Directors and leadership, and the ProgramLeads. In addition to facilitating collaborations across the CHOP PCEN collaborators at CHOP, the University of Pennsylvania, and Johns Hopkins University, the Administrative Core will support interdisciplinary partnerships across the CHOP PCEN research base and the PCEN Network. Our team includes individuals with proven track records in mentoring, basic science, translational research, clinical investigation, epidemiology, informatics, and health services research. We will build upon the success of our established PCEN to expand the evidence base of observational data for clinical trial design and enhance the infrastructure for pragmatic clinical trials and comparative effectiveness through the LHS Core; facilitate the identification of novel therapeutic targets through the MPNC; foster collaboration in kidney disease research across other centers; and mentor members of the broader nephrology community by supporting the Enrichment Program, an Opportunity Pool Program, and innovative research projects in childhood kidney disease.

行政核心项目摘要 行政核心的总体目标是为 PCEN 和 确保其有效和高效的运作。行政核心将促进两个生物医学部门的工作 研究核心、学习健康系统核心（LHS 核心）和分子精准肾病学核心 (MPNC)，并支持丰富计划、机会池试点和可行性计划，以及两个 研究项目。强化计划旨在为研究基地配备额外的技能和 最大限度地提高 PCEN 内的互动和知识讨论。丰富计划内的举措将 鼓励和支持早期职业生涯中小儿肾脏疾病的创新性多学科研究 参与，包括暑期学者计划；职业发展和合作；和耐心， 家庭和社区参与。机会池试点和可行性计划将继续刺激 并征求新的项目想法，以解决儿科肾病学研究进展的主要障碍，特别是 早期研究人员、新研究人员或以前未参与过相关研究的已建立的研究人员 小儿肾脏疾病。 CHOP PCEN 组织结构包括外部顾问的监督 董事会 (EAB) 以及科学咨询委员会 (SAC) 的意见和指导。指导委员会将 为 CHOP PCEN 制定总体政策，包括中心联合主任、SAC 主席、生物医学委员会 核心董事和领导层以及项目负责人。除了促进 CHOP 之间的合作外 PCEN 在 CHOP、宾夕法尼亚大学和约翰·霍普金斯大学、行政学院的合作者 Core 将支持 CHOP PCEN 研究基地和 PCEN 网络之间的跨学科合作。 我们的团队包括在指导、基础科学、转化研究、 临床调查、流行病学、信息学和卫生服务研究。我们将在成功的基础上再接再厉 我们建立的 PCEN 旨在扩大临床试验设计观察数据的证据基础并增强 通过 LHS 核心进行实用临床试验和比较有效性的基础设施；促进 通过 MPNC 识别新的治疗靶点；促进肾脏疾病研究方面的合作 跨越其他中心；并通过支持丰富活动来指导更广泛的肾病学界的成员 计划、机会池计划以及儿童肾脏疾病的创新研究项目。