CHOP Pediatric Center of Excellence in Nephrology

CHOP 儿科肾病卓越中心

基本信息

批准号：
10705295
负责人：
Michelle Denburg
金额：
$ 90.04万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-18 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705295
关键词：
Acceleration Acute Address Adult Atlases Bioinformatics Biometry Cells Child Childhood Chronic Chronic Kidney Failure Clinical Clinical Practice Guideline Clinical Research Clinical Trials Clinical Trials Design Clinical effectiveness Collaborations Comparative Effectiveness Research Consultations Core Facility Data Data Element Data Science Dedications Diagnosis Disease Disease Progression Disease remission Educational Status Effectiveness Evaluation Event Faculty Family Fluid Balance Focal and Segmental Glomerulosclerosis Fostering Foundations Fracture Funding Generations Health system Human Infection Infrastructure Institution Intervention Kidney Kidney Diseases Learning Maps Mentors Methodology Methods Mission Molecular Molecular Target National Institute of Diabetes and Digestive and Kidney Diseases Natural History Nephrology Normal saline Observational Study Outcome Outcomes Research Pathogenesis Patients Pediatric Hospitals Pennsylvania Philadelphia Pragmatic clinical trial Process Proteinuria Proteome Recurrence Research Research Design Research Institute Research Methodology Research Personnel Research Project Grants Resources Risk Reduction Sampling Sepsis Services Structural Models Testing Therapeutic Time Tissue Banks Tissue Sample Translations Universities Work acute care base clinical phenotype clinical trial implementation cohort comparative effectiveness comparative effectiveness study comparative effectiveness trial computable phenotypes data quality data resource design epigenome evidence base improved innovation molecular phenotype nephrogenesis new therapeutic target novel pediatric department phenotyping algorithm pragmatic trial programs skeletal therapeutic target tool treatment effect virtual young adult

项目摘要

CENTER OVERVIEW PROJECT SUMMARY With this renewal, the Pediatric Center of Excellence in Nephrology at the Children’s Hospital of Philadelphia (CHOP PCEN) will continue to facilitate extensive collaborative research around the causes, diagnoses, and treatment of childhood kidney diseases. Increasing efficiency and effectiveness, the CHOP PCEN will continue its focus to break down barriers to clinical trials implementation in our patients. In its initial four years of funding, the CHOP PCEN has partnered with PEDSnet through the Learning Health System (LHS) Core to establish a national interconnected, multi-institutional infrastructure focused on childhood kidney disease. The LHS Core has extended the data science work of PEDSnet to establish an embedded Pediatric Nephrology Data Resource that emphasizes data elements and data quality optimization central to studies of kidney disease. In the next funding cycle, the LHS Core will provide expanded services for comparative effectiveness and pragmatic trials in pediatric nephrology. Through the addition of the Molecular Precision Nephrology (MPN) Core, we will facilitate identification of novel targets to expand therapeutic options for children and youngadults with kidney disease. The MPN Core is uniquely poised to address critical barriers to the clinical and research implementation of molecular precision tools in pediatric nephrology. The Administrative Core facilitates consultation with experts in study design and analysis to achieve appropriate inferences from observational data, and in this proposal, to design comparative effectiveness studies and pragmatic clinical trials. The Administrative Core will support the Opportunity Pool Pilot and Feasibility Program, the Enrichment Program, and two Research Projects that apply innovative approaches to the data resources of the LHS Core and NIDDK consortia (CKiD and CureGN) to address clinically important evidence gaps. One project will examine comparative effectiveness of balanced fluids versus normal saline to reduce the risk of acute and chronic kidney diseasein children with sepsis. The second project will develop, test, and apply a novel class of marginal structural models to estimate time-varying treatment effects on different types of recurrent time-to-event outcomes, including proteinuria remission, infection-related acute care, and skeletal fracture. The PCEN will build upon the strong foundation of pediatric nephrology research at CHOP and Johns Hopkins University as well as successful collaborations with other pediatric nephrology centers and adult nephrology colleagues at the University of Pennsylvania. We will amplify these interactions across institutions to accelerate translation of discoveries into therapies for children and young adults with kidney disease.

中心概况项目概要通过此次更新，儿童医院的儿科肾病卓越中心费城 (CHOP PCEN) 将继续促进围绕儿童肾脏疾病的病因、诊断和治疗，提高效率和治疗效果。有效性，CHOP PCEN 将继续专注于打破临床试验障碍在资助的最初四年中，CHOP PCEN 进行了合作。通过学习健康系统 (LHS) 核心与 PEDSnet 合作，建立国家相互关联的多机构基础设施，重点关注儿童肾脏疾病。 Core 扩展了 PEDSnet 的数据科学工作，建立了嵌入式儿科强调数据元素和数据质量优化中心的肾病数据资源在下一个资助周期中，LHS 核心将提供扩展的肾脏疾病研究。儿科肾病学比较有效性和实用试验服务。增加分子精准肾病学 (MPN) 核心，我们将促进新型药物的鉴定 MPN 的目标是扩大患有肾脏疾病的儿童和年轻人的治疗选择。 Core 致力于解决临床和研究实施的关键障碍儿科肾病学的分子精准工具促进了咨询。与研究设计和分析专家合作，从观察中得出适当的推论数据，并在本提案中设计比较有效性研究和实用的临床行政核心将支持机会池试点和可行性计划，即浓缩计划和两个对数据应用创新方法的研究项目 LHS Core 和 NIDDK 联盟（CKiD 和 CureGN）的资源来解决临床问题一个项目将研究平衡液体的比较有效性。与生理盐水相比，可降低脓毒症儿童患急性和慢性肾脏疾病的风险。第二个项目将开发、测试和应用一类新型的边际结构模型估计随时间变化的治疗对不同类型的复发性事件发生时间结果的影响，包括蛋白尿缓解、感染相关的急性护理和骨骼骨折。建立在 CHOP 和约翰·霍普金斯大学儿科肾脏病学研究的坚实基础之上大学以及与其他儿科肾病中心和成人的成功合作我们将在宾夕法尼亚大学的肾脏病学同事中扩大这些相互作用。加速将发现转化为儿童和年轻人疗法的机构患有肾脏疾病。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Computer-aided diagnosis of congenital abnormalities of the kidney and urinary tract in children based on ultrasound imaging data by integrating texture image features and deep transfer learning image features.

基于超声成像数据，融合纹理图像特征和深度迁移学习图像特征，计算机辅助诊断儿童肾脏和泌尿道先天性异常。

DOI：
10.1016/j.jpurol.2018.10.020
发表时间：
2019-02-01
期刊：
Journal of pediatric urology
影响因子：
0
作者：
PhD Qiang Zheng;MD PhD Susan L. Furth;M. M. M. Gregory E. Tasian;PhD Yong Fan
通讯作者：
PhD Yong Fan

TRANSFER LEARNING FOR DIAGNOSIS OF CONGENITAL ABNORMALITIES OF THE KIDNEY AND URINARY TRACT IN CHILDREN BASED ON ULTRASOUND IMAGING DATA.

基于超声成像数据诊断儿童肾脏和泌尿道先天性异常的迁移学习。

DOI：
发表时间：
2018-04
期刊：
影响因子：
0
作者：
Zheng, Qiang;Tasian, Gregory;Fan, Yong
通讯作者：
Fan, Yong

Using a Multi-Institutional Pediatric Learning Health System to Identify Systemic Lupus Erythematosus and Lupus Nephritis: Development and Validation of Computable Phenotypes.

使用多机构儿科学习健康系统来识别系统性红斑狼疮和狼疮性肾炎：可计算表型的开发和验证。

DOI：
发表时间：
2022-01
期刊：
影响因子：
0
作者：
Wenderfer, Scott E;Chang, Joyce C;Goodwin Davies, Amy;Luna, Ingrid Y;Scobell, Rebecca;Sears, Cora;Magella, Bliss;Mitsnefes, Mark;Stotter, Brian R;Dharnidharka, Vikas R;Nowicki, Katherine D;Dixon, Bradley P;Kelton, Megan;Flynn, Joseph T;Gluck
通讯作者：
Gluck

Dipping at home: is it better, easier, and more convenient? A feasibility and acceptability study of a novel home urinalysis using a smartphone application.

在家浸泡：更好、更简单、更方便吗？

DOI：
发表时间：
2023-01
期刊：
影响因子：
0
作者：
Erez, Daniella Levy;Derwick, Hannah;Furth, Susan;Ballester, Lance;Omuemu, Stephanie;Adiri, Yonathan;Mink, Jonah;Denburg, Michelle
通讯作者：
Denburg, Michelle

Extraction of hierarchical functional connectivity components in human brain using resting-state fMRI

使用静息态功能磁共振成像提取人脑中的分层功能连接组件