New Faculty Recruitment in Stem Cell and Regenerative Cardiovascular Biology

干细胞和再生心血管生物学新教师招聘

• 批准号: 7937868
• 负责人: Allen W Cowley
• 金额: $ 67.41万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7937868
• 关键词: Adult; Anatomy; Anesthesiology; Animal Model; Animals; Appointment; Area; Basic Science; Behavior; Bioinformatics; Biological Models; Biology; Biomedical Engineering; Biomedical Research; Biophysics; Biotechnology; Blood; Blood Vessels; Cancer Grant Supplements (P30); Candidate Disease Gene; Cardiology; Cardiovascular Diseases; Cardiovascular system; Cell Culture Techniques; Cell Line; Cells; Cellular biology; Centers of Research Excellence; Chairperson; Clinical; Collaborations; Commit; Communities; Complement; Complex; Computational Biology; Congestive Heart Failure; Coronary heart disease; Country; Derivation procedure; Detection; Development; Diabetes Mellitus; Disease; Disease model; Doctor of Medicine; Doctor of Philosophy; Drug Industry; Education; Embryo; Engineering; Environment; Faculty; Fibroblasts; Funding; Gene Targeting; Generations; Genes; Genetic; Genetic Engineering; Genetic Models; Genetic Research; Genomics; Germ Layers; Goals; Grant; Heart; Home environment; Hospitals; Human; Human Genetics; Human Resources; Hypertension; Individual; Injury; Institutes; Institution; Interdisciplinary Study; Kidney; Knock-out; Laboratories; Laboratory Rat; Leadership; Letters; Link; Lung; Medical center; Medicine; Methodology; Modeling; Modification; Molecular Genetics; Mus; Mutagenesis; National Heart, Lung, and Blood Institute; Nephrology; Neurobiology; Obesity; Outcome; Pathogenesis; Pathway interactions; Patients; Pediatric Hospitals; Pediatric Surgical Procedures; Pharmaceutical Preparations; Pharmacology; Physicians; Physiological; Physiology; Pluripotent Stem Cells; Positioning Attribute; Postdoctoral Fellow; Preclinical Testing; Prevention; Principal Investigator; Process; Program Research Project Grants; Proteome; Proteomics; Pulmonology; Rattus; Reagent; Recruitment Activity; Regenerative Medicine; Relative (related person); Renal Hypertension; Reporting; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Rodent Model; Schedule; Schools; Scientist; Somatic Cell; Source; Stem Cell Research; Stem cells; Strategic Planning; Stroke; System; Technology; Time; Tissue Engineering; Tissues; Toxicology; Training; Transgenic Organisms; Translational Research; Trustees; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Validation; Vascular Diseases; Whole Organism; Wisconsin; Work; Zinc Fingers; angiogenesis; base; blastocyst; body system; career; cellular engineering; cerebrovascular; clinical efficacy; drug candidate; drug discovery; embryonic stem cell; experience; functional genomics; gene therapy; genome database; homologous recombination; human disease; human stem cells; induced pluripotent stem cell; innovation; interest; knockout gene; medical schools; member; molecular imaging; multidisciplinary; new technology; novel; nuclease; organ regeneration; pluripotency; pre-clinical; professor; programs; rat genome; regenerative; research and development; skills; square foot; stem; success; technology development; tool

DESCRIPTION (provided by applicant): The Cardiovascular Center (CVC) at the Medical College of Wisconsin (MCW) is a Biomedical Core Center with ongoing research related to the prevention, detection, treatment and cure of the complex set of cardiovascular diseases related to heart, lung, stroke, high blood pressure and renal injury, diabetes, and obesity. The most recent Strategic Plan designated the expansion of the cardiovascular research activities at MCW to be one of the highest priorities. Recent allocation of expanded research space and resources to the CVC to recruit new faculty demonstrates the institutional support of this expansion. We have identified an exciting young scientist, Dr. Aron Geurts, who would advance our goals to develop an innovative research program of excellence in stem cell and regenerative cardiovascular biology. Dr. Geurts with ten years of experience in cell culture and technology development, has been a postdoctoral fellow for the past three years in the Human and Molecular Genetics Center (HMGC) working in the laboratory of Dr. Howard Jacob. He has led the development and application in rats of gene-trap transposon mutagenesis for our NHLBl-PGA program; the creation of the first targeted knockout rats using zinc-finger nucleases; and the reprogramming of rat fibroblasts into induced pluripotent stem cells. This PSO grant would enable the immediate opportunity to provide start-up funds and protected time for Dr. Geurts as a new tenure-track faculty member to develop his own research initiatives to become an independently-funded, NIH-supported investigator. Not only his specific scientific skills and prowess but also his remarkable collaborative abilities make Dr. Geurts a strong candidate for recruitment to enhance research resources in the area of stem cell and regenerative cardiovascular biology developed by the CVC together with the Departments of Physiology, and Cell Biology, Neurobiology and Anatomy, the HMGC, and the Bioengineering and Biotechnology Center. The extensive resources on this campus would provide a pathway of independence for Dr. Geurts while at the same time expanding the institution's community of multidisciplinary researchers focusing on the specific interests of the NHLBI. The CVC has identified an exciting young scientist. Dr. Aron Geurts, who would advance our goals to develop an innovative research program of excellence in stem cell and regenerative cardiovascular biology. The recruitment of Dr. Geurts would enhance research resources in the area of stem cell and regenerative cardiovascular biology for the CVC at MCW.

描述（由申请人提供）：威斯康星州医学院（MCW）的心血管中心（CVC）是一个生物医学核心中心，与预防，检测，治疗和治愈相关的心血管疾病相关的研究持续研究与心脏，肺部，肺部，高压和肾脏损伤，糖尿病和糖尿病，糖尿病和糖尿病和肥胖症相关的复杂心血管疾病。最新的战略计划指定MCW的心血管研究活动的扩展是最高优先事项之一。最近向CVC分配扩展的研究空间和资源以招募新的教职员工证明了这一扩展的机构支持。我们已经确定了一位令人兴奋的年轻科学家Aron Geurts博士，他将促进我们的目标，以开发一项创新的干细胞和再生心血管生物学卓越研究计划。盖尔特博士在细胞文化和技术开发方面拥有十年的经验，在过去三年中，在人类和分子遗传学中心（HMGC）一直是霍华德·雅各布博士的实验室。他领导了我们的NHLBL-PGA计划中基因陷阱转座子诱变大鼠的开发和应用。使用锌指核酸酶创建第一个靶向敲除大鼠；大鼠成纤维细胞重编程为诱导的多能干细胞。这项PSO赠款将使立即机会为Geurts博士作为新的终身教师提供启动资金和保护时间，以制定自己的研究计划，以成为一名独立资助的NIH支持的调查员。 Not only his specific scientific skills and prowess but also his remarkable collaborative abilities make Dr. Geurts a strong candidate for recruitment to enhance research resources in the area of​​ stem cell and regenerative cardiovascular biology developed by the CVC together with the Departments of Physiology, and Cell Biology, Neurobiology and Anatomy, the HMGC, and the Bioengineering and Biotechnology Center.该校园的广泛资源将为盖尔特博士提供独立的途径，同时扩大该机构的多学科研究人员社区，重点关注NHLBI的特定利益。 CVC确定了一位令人兴奋的年轻科学家。 Aron Geurts博士，他将促进我们的目标，以制定创新的干细胞和再生心血管生物学卓越研究计划。 Geurts博士的招募将增强干细胞领域的研究资源和MCW CVC再生心血管生物学。