New Faculty in Sleep Medicine

睡眠医学新教师

• 批准号: 7936162
• 负责人: Charles A Czeisler
• 金额: $ 36.06万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7936162
• 关键词: Area; Award; Behavioral; Blood Vessels; Cardiovascular system; Circadian Rhythms; Clinical; Clinical Trials; Commit; Complement; Data; Development; Disease; Epidemiologic Studies; Epidemiology; Event; Faculty; Functional disorder; Funding; Future; Hemostatic Agents; Hospitals; Hypertension; Individual; Institution; Lead; Measures; Medicine; Mentorship; Mission; Myocardial Infarction; National Heart, Lung, and Blood Institute; Non obese; Obesity; Outcome; Patients; Pattern; Phase; Physiologic Monitoring; Physiology; Play; Population; Postdoctoral Fellow; Posture; Protocols documentation; Request for Applications; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Risk Marker; Role; Science; Sleep; Sleep Disorders Therapy; Stroke; System; Time; Training; Translations; Vulnerable Populations; Wages; Woman; behavior influence; cardiovascular risk factor; career; career development; catalyst; circadian behavioral rhythms; circadian pacemaker; forging; hemodynamics; next generation; normotensive; professor; programs; research facility; stressor; sudden cardiac death

DESCRIPTION (provided by applicant): This NHLBI PSO application requests funding for two years salary plus appropriate start up funds for a newly independent investigator whose research will complement the research underway in the Brigham & Women's Hospital's (BWH) Division of Sleep Medicine's research center. The research center's mission is to forge a path of discovery in sleep medicine and to train the next generation of leaders in academic sleep medicine. The Division has 31 faculty, 20 postdoctoral fellows and over 50 support staff, with the majority of effort spent on research. These research activities are funded by annual research grants of ~$11.8 million. The Division has a number of interacting research programs and cores, covering most aspects of sleep and circadian physiology, as well as sleep pathophysiology (mechanisms and therapy for the sleep disorders). However, we have identified an important area of research that is not currently well studied in our center, namely the interaction of the circadian system with disease. In particular, there is a critical gap in our understanding of the role of the circadian timing system in causing the very robust morning increase in adverse cardiovascular events (strokes, myocardial infarction, and sudden cardiac death) in vulnerable patient groups. We have identified a spectacular newly independent investigator whose research has moved in this direction and who is poised for promotion to Assistant Professor of Medicine. Should this P03 award be made, the institution is committed to providing appropriate research facilities for this individual, including use of the BWH Intensive Physiological Monitoring Unit in the Center for Clinical Investigation, a component of the Harvard Catalyst-Clinical and Translation Science Center. In addition, the investigator will fully utilize the many career development resources in the BWH Center for Faculty Development and Diversity. Together with close research and career mentorship from senior faculty in the Division's research center, we anticipate that a PSO award will lead to important discoveries concerning the role of the circadian system in the day/night pattern of adverse cardiovascular events, and greatly facilitate the career development of one of the most promising future leaders in academic sleep medicine. A PSO award will lead to important discoveries concerning the role of the circadian system in the very robust day/night pattern of adverse cardiovascular events, and greatly facilitate the career development of one of the most promising future leaders in academic sleep medicine.

描述（由申请人提供）：该NHLBI PSO申请要求为两年的薪水提供资金，并为新独立的研究人员提供适当的启动资金，其研究将补​​充Brigham＆妇女医院（BWH）睡眠医学研究中心的研究。该研究中心的任务是为睡眠医学的发现途径，培训学术睡眠医学领域的下一代领导者。该部门有31位教职员工，20名博士后研究员和50多名支持人员，大部分努力在研究上。这些研究活动由约1,180万美元的年度研究赠款资助。该部门具有许多相互作用的研究计划和核心，涵盖了睡眠和昼夜节律生理学的大多数方面，以及睡眠病理生理学（睡眠障碍的机制和治疗）。但是，我们已经确定了一个重要的研究领域，该研究目前在我们的中心尚未对研究，即昼夜节律系统与疾病的相互作用。特别是，我们对昼夜节律定时系统在导致心血管不良事件（中风，心肌梗塞和突然心脏死亡）中非常强大的早晨增加的作用的理解中存在一个危险的差距。我们已经确定了一位壮观的新独立研究者，其研究已朝这个方向发展，并准备晋升为医学助理教授。如果要颁发该P03奖，该机构将致力于为该人提供适当的研究设施，包括在临床研究中心使用BWH强化生理监测单位，这是哈佛大学催化剂 - 临床和翻译科学中心的组成部分。此外，研究人员将充分利用BWH教师发展与多样性中心的许多职业发展资源。加上该部门研究中心高级教师的仔细研究和职业指导，我们预计PSO奖将导致有关昼夜节律系统在不良心血管事件的白天/夜间模式中的作用的重要发现，并极大地促进了学术睡眠医学中最有希望的未来领导者之一的职业发展。 PSO奖将导致关于昼夜节律系统在不良心血管事件的非常强大的日/夜模式中的作用的重要发现，并极大地促进了职业发展，这是学术睡眠医学中最有前途的未来领导者之一。