Regenerative Biology Center at the MBL

MBL 再生生物学中心

• 批准号: 7944074
• 负责人: Gary G Borisy
• 金额: $ 40.13万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944074
• 关键词: Aging; Area; Award; Be++ element; Beryllium; Biodiversity; Biological; Biological Models; Biology; Biomedical Research; Cells; Center Core Grants; Commit; Country; Elements; Embryology; Equipment; Faculty; Funding; Genome; Genomics; Grant; Health; Home environment; Human; Image; Individual; Informatics; Invertebrates; Investments; Knowledge; Laboratories; Laboratory Scientists; Marine Invertebrates; Marines; Massachusetts; Medical; Medical center; Modeling; Mus; National Center for Research Resources; Natural regeneration; Neurobiology; Organ; Organism; Physiology; Positioning Attribute; Primates; Process; Recruitment Activity; Regenerative Medicine; Regulator Genes; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Science; Scientist; Senior Scientist; System; Time; Tissues; Training Programs; Universities; Wages; Wood material; Work; Xenopus; marine organism; member; multidisciplinary; professor; programs; regenerative; repaired; stem cell biology

DESCRIPTION (provided by applicant): The Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, proposes to launch a high-impact, multidisciplinary and unique initiative in regenerative and stem cell biology drawing upon the special advantages of marine invertebrates. Regenerative and stem cell biology is being recognized in medical centers across the country as a critical area of science for establishing the potential of regenerative medicine. In this emerging field, scientists seek to define and understand the natural processes by which damaged or aging tissues and organs can regenerate or be repaired, and to apply that knowledge to developing medical therapies. Although mammalian systems are unquestionably of direct relevance and great importance for human health, non-mammalian models including bacterial, fungal, invertebrate and vertebrate systems have contributed enormously to our understanding of the fundamental cell and tissue biology that underpin medical advances. Among possible model systems, marine invertebrates and lower vertebrate organisms hold great promise specifically as research models for regeneration, particularly as the field progresses in decoding their genomes. The MBL has invested in the cognate areas of cellular dynamics, imaging, genomics, marine husbandry and biodiversity informatics. The MBL is renowned for its advanced research training programs in physiology, neurobiology, embryology and gene regulatory networks. We believe the physical and intellectual infrastructure investments already made at the MBL pre- adapt it to launch a new initiative in Regenerative Biology. The missing element is to establish a critical mass of individuals focused on this area. The P30 program support is vital for recruiting two individuals who, with existing MBL scientists, would provide the critical mass for establishing the Center. We believe that the time is ripe to exploit the special experimental potential of marine organisms and that the MBL is uniquely pre- adapted to serve as the home for a new Center for Regenerative Biology.

描述（由申请人提供）：位于马萨诸塞州伍兹霍尔的海洋生物实验室（MBL）提议利用海洋无脊椎动物的特殊优势，在再生和干细胞生物学方面发起一项高影响力、多学科和独特的举措。再生和干细胞生物学正在全国各地的医疗中心被认为是发挥再生医学潜力的关键科学领域。在这个新兴领域，科学家们试图定义和理解受损或老化的组织和器官再生或修复的自然过程，并将这些知识应用于开发医学疗法。尽管哺乳动物系统无疑与人类健康直接相关且非常重要，但包括细菌、真菌、无脊椎动物和脊椎动物系统在内的非哺乳动物模型为我们对支撑医学进步的基本细胞和组织生物学的理解做出了巨大贡献。在可能的模型系统中，海洋无脊椎动物和低等脊椎动物作为再生研究模型具有巨大的前景，特别是随着解码其基因组领域的进展。 MBL 投资于细胞动力学、成像、基因组学、海洋畜牧业和生物多样性信息学等相关领域。 MBL 以其生理学、神经生物学、胚胎学和基因调控网络方面的高级研究培训项目而闻名。我们相信，MBL 已经进行的物理和智力基础设施投资可以对其进行预先调整，以启动再生生物学的新计划。缺少的要素是建立专注于该领域的临界数量的个人。 P30 计划的支持对于招募两名个人至关重要，他们与现有的 MBL 科学家一起，将为建立该中心提供关键力量。我们相信，开发海洋生物特殊实验潜力的时机已经成熟，并且 MBL 具有独特的适应性，可以作为新的再生生物学中心的所在地。