Yale Cellular Neuroscience, Neurodegeneration and Repair (CNNR) Program

耶鲁大学细胞神经科学、神经变性和修复 (CNNR) 项目

• 批准号: 7941761
• 负责人: STEPHEN M STRITTMATTER
• 金额: $ 76.2万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7941761
• 关键词: Yale; Cellular; Neuroscience; Neurodegeneration; Repair

DESCRIPTION (provided by applicant): The Yale Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR) was co-founded by the PI and Co-PI four years ago with the goal of linking basic research in neuronal cell biology with efforts to advance pathophysiological understanding of neurodegenerative disease and neural repair. We hypothesized that strong synergies will result from bringing together researchers in disease-oriented science with experts in the cell biology of the nervous system. To date we have recruited 5 new faculty into contiguous laboratory space, interconnected them with other neuroscientists at Yale, and established an advanced core facility for imaging and functional genomics of neurons. Here, we propose the recruitment of two additional Assistant Professors into the Yale CNNR in order to fill key unmet needs in our Program. The vigorous research programs already launched by existing faculty will interdigitate with those of the two new Recruits and will foster their success and the overall success of the CNNR. It is anticipated that one Recruit will fill a crucial role by providing electrophysiological expertise at the single cell level coupled with optical techniques. A Recruit using these methods will have a fertile ground for selecting molecular biology collaborators from amongst the existing CNNR faculty. Such a Recruit will also provide a new dimension of ongoing explorations of neuronal function in health and disease. The second Recruit is expected to lead a program centered on the cell biology of Alzheimer's Disease. While this is the most prevalent neurological condition, Yale has no laboratory focused primarily on this disorder. With this Recruit, the Yale CNNR will allow the wealth of nerve cell biology at Yale to be applied to Alzheimer's Disease. Importantly, the CNNR environment will provide the new Assistant Professor with a strong basic science expertise and fresh ideas towards an improved pathophysiological understanding, and eventually a treatment, of this condition. Yale has committed laboratory space and will provide two-thirds of the funds for the new Recruits, but the proposed support is essential to provide the resources necessary for recruitment of two new Assistant Professors into the Yale CNNR.

描述（由申请人提供）：四年前，PI和CO-PI共同创立了细胞神经科学，神经退行性和修复（CNNR）的耶鲁大学计划，其目的是将神经元细胞生物学的基础研究与促进神经性疾病疾病和神经修复的病理生理理解联系起来。我们假设，强大的协同作用将是由将疾病科学研究人员与神经系统细胞生物学专家联系起来的。迄今为止，我们已经招募了5个新教师到连续的实验室空间，并与耶鲁大学的其他神经科学家相互联系，并建立了用于神经元成像和功能基因组学的先进核心设施。在这里，我们建议将另外两名助理教授招募到耶鲁大学CNNR中，以满足我们计划中的关键需求。现有教师已经启动的有力的研究计划将与这两个新兵的研究互动，并将促进他们的成功和CNNR的整体成功。可以预计，一个招募将通过在单细胞水平上提供电生理学专业知识，并加上光学技术来填补至关重要的作用。使用这些方法的新兵将有一个沃土，可以从现有的CNNR教师中选择分子生物学合作者。这样的新兵还将为健康和疾病中神经元功能的持续探索提供一个新的维度。预计第二名新兵将领导以阿尔茨海默氏病细胞生物学为中心的计划。尽管这是最普遍的神经系统疾病，但耶鲁大学没有主要关注这种疾病的实验室。借助这一新兵，耶鲁大学CNNR将允许耶鲁大学的大量神经细胞生物学应用于阿尔茨海默氏病。重要的是，CNNR环境将为新的助理教授提供强大的基础科学专业知识和新的想法，以改善病理生理理解，并最终对这种状况进行治疗。耶鲁大学曾承诺实验室空间，并将为新兵提供三分之二的资金，但是拟议的支持对于提供招募两名新助理教授到耶鲁大学的必要资源至关重要。