Cancer Adoptive Cell Therapy (Can-ACT) Network Coordinating Center at Mayo Clinic

梅奥诊所癌症过继细胞治疗 (Can-ACT) 网络协调中心

• 批准号: 10730805
• 负责人: Yan W. Asmann
• 金额: $ 48.03万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730805
• 关键词: Administrative Coordination; Administrative Supplement; Adoptive Cell Transfers; Adult; Animal Model; Area; Bioinformatics; Biological; Biological Specimen Banks; Biometry; Cancer Center; Cell Therapy; Cells; Childhood; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communication; Communities; Data; Data Collection; Data Management Resources; Data Science; Data Security; Development; Elements; Foundations; Funding; Human; Individual; Industry; Infrastructure; Institution; Leadership; Learning; Malignant Neoplasms; Multicenter Trials; Oncology; Patients; Policies; Positioning Attribute; Process; Reagent; Research; Research Personnel; Resources; Solid Neoplasm; Specimen; Standardization; Structure; Testing; Therapeutic; Therapeutic Agents; Translational Research; Work; anticancer research; biobank; clinical translation; data harmonization; data management; data sharing; data submission; design; early phase clinical trial; electronic data; experience; innovation; interest; manufacture; meetings; member; novel therapeutics; operation; pre-clinical; pre-clinical research; preclinical development; preclinical study; programs; research study; synergism; treatment response; web site; working group

PROJECT SUMMARY/ABSTRACT – NETWORK COORDINATING CENTER The Network Coordinating Center (NCC) will facilitate and be responsible for network-wide coordination and harmonization of scientific and clinical needs of the funded UG3/UH3 centers comprising the Cancer Adoptive Cellular Therapeutics (Can-ACT) Network. The Network Coordinating Center at Mayo Clinic (NCC-MC) will serve as the administrative hub and coordinating center for all network-related trials and projects. This will include multiple aspects of the functioning of this network, including the administrative and scientific coordination of the Can-ACT Network. The administrative coordination will include (a) providing leadership and facilitating interactions across the network, (b) providing administrative infrastructure to support the activities of the Can-ACT Network, and (c) the coordination of the restricted collaborative funds and administrative supplements for the network. Scientific coordination of this network will include several different critical components, including (a) identifying and establishing strategies for facilitating reagent and specimen sharing, (b) identification and harmonization of process development and manufacturing steps for cell product management and utilization for the functioning of the network between centers and the ICN Core, (c) biostatistical support and collaboration for preclinical and clinical research studies and centralized data management and shared data governance, and (d) bioinformatics and data science support and collaboration. The infrastructure, expertise, and experience of the individuals at Mayo Clinic with national coordination of translational and clinical research is extensive, making this group well-positioned to function as an outstanding coordinating center for the Can-ACT Network. The leadership of this proposed coordinating center brings with them complementary and deep experience and background across these key aims, and they have worked extensively with multi-institutional trials, consortia, and networks as well as cooperative groups in research leadership, trial coordination and implementation, data structures, and importantly development of SOPs and guidance for newly formed collaborative research networks across multiple institutions. Beyond the experience and expertise, the NCC-MC also leverages institutional infrastructure and resources to adapt and evolve as the Can-ACT Network develops and grows through the expected and necessary collaborations across all UG3/UH3 centers and project leaders.

项目概要/摘要——网络协调中心 网络协调中心（NCC）将促进并负责网络范围内的协调和 协调由癌症收养中心组成的受资助 UG3/UH3 中心的科学和临床需求 梅奥诊所 (NCC-MC) 的细胞治疗 (Can-ACT) 网络。 作为所有网络相关试验和项目的行政中心和协调中心。 包括该网络运作的多个方面，包括行政和科学 Can-ACT 网络的协调 行政协调将包括 (a) 提供领导和 促进整个网络的互动，(b) 提供行政基础设施以支持活动 Can-ACT 网络，以及 (c) 有限合作资金和行政管理的协调 该网络的科学协调将包括几个不同的关键内容。 组成部分，包括 (a) 确定和制定促进试剂和样本共享的战略， (b) 确定和协调细胞产品的工艺开发和制造步骤 管理和利用各中心和 ICN 核心之间网络的运作，(c) 临床前和临床研究以及集中数据的生物统计支持与协作 管理和共享数据治理，以及 (d) 生物信息学和数据科学支持与协作。 梅奥诊所的基础设施、专业知识和个人经验以及国家协调 转化和临床研究广泛，使该小组有能力成为杰出的 Can-ACT 网络协调中心 该拟议协调中心的领导层带来了 他们在这些关键目标上互补且深厚的经验和背景，并且他们已经努力工作 通常采用多机构试验、联盟、网络以及研究合作团体 领导、试验协调和实施、数据结构以及标准操作程序和标准操作程序的重要制定 为跨多个机构新成立的合作研究网络提供指导 超越经验。 和专业知识，NCC-MC 还利用机构基础设施和资源来适应和发展 Can-ACT 网络通过所有领域的预期和必要的合作来发展和壮大 UG3/UH3 中心和项目负责人。