Development of New Technologies at Roswell Park to Further Cancer-Based Research and Treatment Through Genome Modification

罗斯威尔公园开发新技术，通过基因组修饰进一步开展基于癌症的研究和治疗

• 批准号: 10733275
• 负责人: Aimee B Stablewski
• 金额: $ 32.49万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733275
• 关键词: Animal Model; Applications Grants; Area; Biology; Cancer Center; Cancer Center Support Grant; Cell Line; Cells; Collaborations; Comprehensive Cancer Center; Consult; Consultations; Dedications; Development; Developmental Therapeutics Program; Doctor of Philosophy; Ensure; Funding; Gene Targeting; Genetic; Genetically Modified Animals; Genome; Grant; Infrastructure; Investments; Laboratories; Malignant Neoplasms; Modification; Positioning Attribute; Principal Investigator; Privatization; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Scientist; Specialist; Stress; Technology; Transgenic Organisms; United States National Institutes of Health; Wages; base; cancer research center director; career; experience; genome editing; member; neoplasm immunotherapy; new technology; programs; tool; tumor immunology

Abstract The current application seeks salary support for Aimee Stablewski, PhD who serves as the Director of the Gene Targeting and Transgenic Shared Resource (GeTT) of Roswell Park Comprehensive Cancer Center (Roswell Park). This position was created in 1999 to oversee the research applications of the various genome editing platforms available in the resource and to apply her extensive experience in these areas in collaborations and consultations with the GeTT investigator user base. With over 25 years of experience in research applications of the creation of genetically modified animals and cells (23 years at Roswell Park), Dr. Stablewski throughout her career has collaborated with many investigators at the Cancer Center on NIH funded projects. The GeTT is an integral part of Roswell Park's Cancer Center Support grant (P30CA016056) for which the cancer center Director, Dr. Johnson, serves as the Principal Investigator. All three CCSG programs (Developmental Therapeutics (DT), Tumor Immunology and Immunotherapy (TII) and Cancer Stress Biology (CSB) equally make up the user base of the GeTT; and numerous NIH-funded researchers in these programs actively collaborate and consult with Dr. Stablewski. Dr. Stablewski' s contributions to Roswell Parks research enterprise have been significant and impactful specifically with regards to the NIH-funded research of the members of the TII program. As of September 2022, there are thirty-nine grant applications that cited use of the GeTT shared resources. There were twenty-six NIH/ NCI, two DOD, and the remaining applications include private and public funding sponsors, eleven of whom were TII Program members, fourteen are CSB members and nine are DT members. The cancer center has also made significant investments in the GeTT with regards to advancing technology in genetic modifications. With the changes in the R50 program now making the distinction between Laboratory (PAR-20-288) and Core (PAR-20-287) based scientists and with the GeTT being an integral part of the Roswell Park CCSG infrastructure, Dr. Johnson as the PI of the CCSG grant, will now serve as the Unit Director for the application.

抽象的 目前的申请为担任该项目主任的 Aimee Stablewski 博士寻求薪资支持。 罗斯威尔公园综合癌症中心的基因打靶和转基因共享资源 (GeTT) （罗斯威尔公园）。该职位于 1999 年设立，负责监督各种基因组的研究应用 资源中可用的编辑平台，并将她在这些领域的丰富经验应用于 与 GeTT 研究者用户群的合作和咨询。拥有超过 25 年的经验 创造转基因动物和细胞的研究应用（在罗斯威尔公园工作 23 年），Dr. Stablewski 在她的整个职业生涯中与 NIH 癌症中心的许多研究人员合作 资助的项目。 GeTT 是罗斯威尔公园癌症中心支持赠款 (P30CA016056) 的组成部分 癌症中心主任约翰逊博士担任首席研究员。所有三个 CCSG 项目（发育治疗 (DT)、肿瘤免疫学和免疫治疗 (TII) 和癌症应激 生物学（CSB）同样构成了 GeTT 的用户群；以及众多 NIH 资助的研究人员 项目积极与 Stablewski 博士合作和咨询。 Stablewski 博士对罗斯威尔帕克斯的贡献 研究企业具有重大意义和影响力，特别是在 NIH 资助的研究方面 TII 计划的成员。截至 2022 年 9 月，有 39 份拨款申请引用了使用 GeTT 共享资源。有 26 个 NIH/NCI，两个 DOD，其余的申请 包括私人和公共资助赞助商，其中 11 名是 TII 计划成员，14 名是 CSB 成员，九名是 DT 成员。 癌症中心还对 GeTT 进行了大量投资，以推进技术进步 基因改造。随着 R50 计划的变化，现在实验室与实验室之间有了区别 (PAR-20-288) 和 Core (PAR-20-287) 的科学家，并且 GeTT 是该项目不可分割的一部分 罗斯威尔公园 CCSG 基础设施，Johnson 博士作为 CCSG 拨款的 PI，现在将担任该单位 申请主任。