Nanotubes in tumor imaging and therapy

纳米管在肿瘤成像和治疗中的应用

基本信息

批准号：
7907146
负责人：
Suzy V Torti
金额：
$ 26.78万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7907146
关键词：
Ablation Animal Model Architecture Ballistics Behavior Biological Caliber Carbon Carbon Nanotubes Cell Culture Techniques Cell Death Clinical Complex Contrast Media Copper Cultured Cells Defect Diamond Electromagnetics Engineering Exhibits Exposure to Fractals Goals Heating Human Image In Vitro Injury Iron Kidney Knowledge Length Light Literature Magnetic Resonance Magnetic Resonance Imaging Malignant Neoplasms Measures Mediating Modeling Modification Mus Nanostructures Nanotechnology Nanotubes Normal tissue morphology Paper Property Renal Cell Carcinoma Shapes Signal Transduction Source Steel Structure Testing Theoretical model Tissues Toxic effect Treatment Protocols Tube Variant antitumor agent base cancer therapy chemical property cytotoxic density design heat injury human disease in vivo infancy instrument mathematical model mouse model nanometer novel particle physical property prototype research study tissue culture treatment planning tumor uptake

项目摘要

Carbon nanotubes are graphene sheets of sp2 bonded atoms rolled seamlessly into a tube of 1.5 - 20 nm in diameter. This material has unique properties, including the ability to generate heat when stimulated with infrared light. We have used the features of nanotubes to develop prototype multifunctional multiwalled carbon nanotubes that have the potential to simultaneously image and treat tumors. Our hypothesis is that we can create multifunctional nanotubes that can be used to image and treat mouse models of human renal cell carcinoma. In this proposal will test this hypothesis by fabricating carbon-based nanotubes of different lengths, architectures and composition. We will assess the ability of these nanotubes to function as anti-tumor agents in tissue culture and in mouse models. We will test their ability to generate heat when stimulated with light, and their ability to act as imaging agents. Mathematical modeling will be performed to optimize placement of ferrotubes for optimal heat delivery in tissues. We will optimize treatment schedule for maximal antitumor effect with minimal damage to adjacent tissues. Ultimately, our objective is a therapy that can be precisely directed, exhibits low nonspecific toxicity, is compatible with standard clinical imaging instruments, and is easily cleared by the body. In this proposal, we will use tissue culture and mouse models to take the first steps in characterizing the features of nanotubes that will permit their use in tumor imaging and cancer therapy. Relevance: Carbon nanotubes may represent a new way to image and treat kidney and other cancers. In this proposal we fabricate new nanostructures, test their anti-cancer efficacy in tissue culture and mouse models, and use mathematical modeling to optimize their use.

碳纳米管是由 sp2 键合原子组成的石墨烯片，无缝卷绕成 1.5 - 20 nm 的管状直径。这种材料具有独特的特性，包括在受到刺激时能够产生热量红外线。我们利用纳米管的特性开发了原型多功能多壁碳纳米管有可能同时成像和治疗肿瘤。我们的假设是我们可以创建可用于成像和治疗人类肾细胞小鼠模型的多功能纳米管癌。在该提案中，将通过制造不同长度的碳基纳米管来测试这一假设，架构和组成。我们将评估这些纳米管作为抗肿瘤剂的能力在组织培养和小鼠模型中。我们将测试它们在光刺激下产生热量的能力，以及它们作为显像剂的能力。将进行数学建模以优化布局铁管可在组织中实现最佳热量传递。我们将优化治疗方案以最大程度地抗肿瘤对邻近组织损伤最小的效果。最终，我们的目标是一种可以精确治疗的疗法定向，非特异性毒性低，与标准临床成像仪器兼容，并且易于被身体清除。在本提案中，我们将使用组织培养和小鼠模型迈出第一步描述纳米管的特征，使其可用于肿瘤成像和癌症治疗。相关性：碳纳米管可能代表一种对肾脏和肾脏进行成像和治疗的新方法。其他癌症。在这个提案中，我们制造了新的纳米结构，测试它们的抗癌能力组织培养和小鼠模型中的功效，并使用数学模型来优化他们的用途。