Nanotubes in tumor imaging and therapy

纳米管在肿瘤成像和治疗中的应用

基本信息

批准号：
7454082
负责人：
Suzy V Torti
金额：
$ 34.15万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-01 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7454082
关键词：
Ablation Animal Model Architecture Ballistics Behavior Biological Caliber Carbon Carbon Nanotubes Cell Death Clinical Compatible Complex Contrast Media Copper Cultured Cells Defect Depth Diamond Electromagnetics End Point Engineering Exhibits Exposure to Fractals Goals Heating Human Image In Vitro Injury Iron Kidney Knowledge Length Light Literature Magnetic Resonance Magnetic Resonance Imaging Malignant Neoplasms Measures Mediating Modeling Modification Mus Nanostructures Nanotechnology Nanotubes Normal tissue morphology Numbers Object Attachment Paper Placement Property Public Health Renal Cell Carcinoma Shapes Signal Transduction Source Standards of Weights and Measures Steel Structure Testing Theoretical model Tissues Toxic effect Treatment Protocols Tube Variant antitumor agent base cancer therapy chemical property cytotoxic density design heat injury human disease in vivo infancy instrument mathematical model mouse model nanometer novel particle physical property prototype research study size tissue culture treatment planning tumor uptake

项目摘要

DESCRIPTION (provided by applicant): Carbon nanotubes are graphene sheets of sp2 bonded atoms rolled seamlessly into a tube of 1.5 - 20 nm in diameter. This material has unique properties, including the ability to generate heat when stimulated with infrared light. We have used the features of nanotubes to develop prototype multifunctional multiwalled carbon nanotubes that have the potential to simultaneously image and treat tumors. Our hypothesis is that we can create multifunctional nanotubes that can be used to image and treat mouse models of human renal cell carcinoma. In this application will test this hypothesis by fabricating carbon-based nanotubes of different lengths, architectures and composition. We will assess the ability of these nanotubes to function as anti-tumor agents in tissue culture and in mouse models. We will test their ability to generate heat when stimulated with light, and their ability to act as imaging agents. Mathematical modeling will be performed to optimize placement of ferrotubes for optimal heat delivery in tissues. We will optimize treatment schedule for maximal antitumor effect with minimal damage to adjacent tissues. Ultimately, our objective is a therapy that can be precisely directed, exhibits low nonspecific toxicity, is compatible with standard clinical imaging instruments, and is easily cleared by the body. In this application, we will use tissue culture and mouse models to take the first steps in characterizing the features of nanotubes that will permit their use in tumor imaging and cancer therapy. PUBLIC HEALTH RELEVANCE: Carbon nanotubes may represent a new way to image and treat kidney and other cancers. In this application we fabricate new nanostructures, test their anti-cancer efficacy in tissue culture and mouse models, and use mathematical modeling to optimize their use.

描述（申请人提供）：碳纳米管是 sp2 键合原子的石墨烯片，无缝卷绕成直径 1.5 - 20 nm 的管。这种材料具有独特的特性，包括在红外光刺激下能够产生热量。我们利用纳米管的特性开发了原型多功能多壁碳纳米管，其具有同时成像和治疗肿瘤的潜力。我们的假设是，我们可以制造多功能纳米管，用于成像和治疗人类肾细胞癌的小鼠模型。在本申请中，我们将通过制造不同长度、结构和成分的碳基纳米管来测试这一假设。我们将评估这些纳米管在组织培养和小鼠模型中作为抗肿瘤剂的能力。我们将测试它们在光刺激下产生热量的能力，以及它们作为成像剂的能力。将进行数学建模来优化铁管的放置，以实现组织中的最佳热量传递。我们将优化治疗方案，以获得最大的抗肿瘤效果，同时对邻近组织的损害最小。最终，我们的目标是一种可以精确定向、非特异性毒性低、与标准临床成像仪器兼容并且易于被身体清除的疗法。在此应用中，我们将使用组织培养和小鼠模型来表征纳米管的特征，从而使其可用于肿瘤成像和癌症治疗。公共健康相关性：碳纳米管可能代表一种成像和治疗肾癌和其他癌症的新方法。在此应用中，我们制造了新的纳米结构，在组织培养和小鼠模型中测试其抗癌功效，并使用数学模型来优化其使用。