Nanotubes in tumor imaging and therapy

纳米管在肿瘤成像和治疗中的应用

• 批准号: 7454082
• 负责人: Suzy V Torti
• 金额: $ 34.15万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7454082
• 关键词: Ablation; Animal Model; Architecture; Ballistics; Behavior; Biological; Caliber; Carbon; Carbon Nanotubes; Cell Death; Clinical; Compatible; Complex; Contrast Media; Copper; Cultured Cells; Defect; Depth; Diamond; Electromagnetics; End Point; Engineering; Exhibits; Exposure to; Fractals; Goals; Heating; Human; Image; In Vitro; Injury; Iron; Kidney; Knowledge; Length; Light; Literature; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Mediating; Modeling; Modification; Mus; Nanostructures; Nanotechnology; Nanotubes; Normal tissue morphology; Numbers; Object Attachment; Paper; Placement; Property; Public Health; Renal Cell Carcinoma; Shapes; Signal Transduction; Source; Standards of Weights and Measures; Steel; Structure; Testing; Theoretical model; Tissues; Toxic effect; Treatment Protocols; Tube; Variant; antitumor agent; base; cancer therapy; chemical property; cytotoxic; density; design; heat injury; human disease; in vivo; infancy; instrument; mathematical model; mouse model; nanometer; novel; particle; physical property; prototype; research study; size; tissue culture; treatment planning; tumor; uptake

DESCRIPTION (provided by applicant): Carbon nanotubes are graphene sheets of sp2 bonded atoms rolled seamlessly into a tube of 1.5 - 20 nm in diameter. This material has unique properties, including the ability to generate heat when stimulated with infrared light. We have used the features of nanotubes to develop prototype multifunctional multiwalled carbon nanotubes that have the potential to simultaneously image and treat tumors. Our hypothesis is that we can create multifunctional nanotubes that can be used to image and treat mouse models of human renal cell carcinoma. In this application will test this hypothesis by fabricating carbon-based nanotubes of different lengths, architectures and composition. We will assess the ability of these nanotubes to function as anti-tumor agents in tissue culture and in mouse models. We will test their ability to generate heat when stimulated with light, and their ability to act as imaging agents. Mathematical modeling will be performed to optimize placement of ferrotubes for optimal heat delivery in tissues. We will optimize treatment schedule for maximal antitumor effect with minimal damage to adjacent tissues. Ultimately, our objective is a therapy that can be precisely directed, exhibits low nonspecific toxicity, is compatible with standard clinical imaging instruments, and is easily cleared by the body. In this application, we will use tissue culture and mouse models to take the first steps in characterizing the features of nanotubes that will permit their use in tumor imaging and cancer therapy. PUBLIC HEALTH RELEVANCE: Carbon nanotubes may represent a new way to image and treat kidney and other cancers. In this application we fabricate new nanostructures, test their anti-cancer efficacy in tissue culture and mouse models, and use mathematical modeling to optimize their use.

描述（由申请人提供）：碳纳米管是SP2键合原子的石墨烯片，无缝地滚动到直径为1.5-20 nm的管中。该材料具有独特的特性，包括用红外光刺激产生热量的能力。我们已经使用纳米管的特征来开发原型多功能多壁碳纳米管，这些碳纳米管具有同时形象和治疗肿瘤的可能性。我们的假设是，我们可以创建可用于图像和治疗人肾细胞癌的小鼠模型的多功能纳米管。在此应用中，将通过制造不同长度，结构和组成的碳的纳米管来检验该假设。我们将评估这些纳米管在组织培养和小鼠模型中充当抗肿瘤剂的能力。我们将测试他们在用光刺激时产生热量的能力，以及它们充当成像剂的能力。将进行数学建模，以优化纤维管的放置，以在组织中最佳的热量输送。我们将优化治疗时间表，以实现最大抗肿瘤效应，对相邻组织的损害最小。最终，我们的目标是一种可以精确定向的疗法，表现出低的非特异性毒性，与标准的临床成像仪器兼容，并且很容易被人体清除。在此应用中，我们将使用组织培养和小鼠模型来表征纳米管的特征，以允许它们在肿瘤成像和癌症治疗中使用。 公共卫生相关性：碳纳米管可能代表了一种形象和治疗肾脏和其他癌症的新方法。在此应用中，我们制造了新的纳米结构，测试其在组织培养和小鼠模型中的抗癌功效，并使用数学建模来优化其使用。